ProRule PRU01071
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01071 |
| Accession | PRU01071 |
| Dates | 24-OCT-2014 (Created)
22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51735; VP35_IID |
Name | Filoviruses VP35 interferon inhibitory domain profile |
| Function | VP35 contains an N-terminal coiled-coil domain required for its oligomerization and a C-terminal interferon (IFN) inhibitory domain (IID). The VP35 IID can bind dsRNA and VP35-mediated IFN antagonism correlates with dsRNA-binding activity. |
| Scope(s) |
Viruses Filoviridae |
| Example(s) | Q6UY68 (VP35_MABVO); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the filoviridae polymerase cofactor VP35 family. |
Features
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| From: PS51735 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="VP35 IID #" | |||||||||
Additional information
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| Size range | 116-136 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [10] All [ 10 ]
- Retrieve set of proteins with 3D structure for this domain