PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01071


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01071
General rule information [?]

Accession PRU01071
Dates 24-OCT-2014 (Created)
22-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51735; VP35_IID
Name Filoviruses VP35 interferon inhibitory domain profile
Function VP35 contains an N-terminal coiled-coil domain required for its oligomerization and a C-terminal interferon (IFN) inhibitory domain (IID). The VP35 IID can bind dsRNA and VP35-mediated IFN antagonism correlates with dsRNA-binding activity.
Scope(s) Viruses
Filoviridae
Example(s) Q6UY68;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the filoviridae polymerase cofactor VP35 family.

Features [?]

From: PS51735
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="VP35 IID #"

Additional information [?]

Size range 116-136 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]