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ProRule PRU01082


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01082
Accession PRU01082
Dates 4-FEB-2015 (Created)
3-SEP-2024 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51746; PPM_2
Name PPM-type phosphatase domain
Function The 300-residue protein phosphatase Mg(2+)- or Mn(2+)-dependent (PPM)-type phosphatase domain that catalyzes the dephosphorylation of phosphoserine- and phosphothreonine-containing protein.
Scope(s) Eukaryota
Bacteria
Viruses
Mimivirus
Example(s) Q7XR06 (P2C45_ORYSJ);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=3.1.3.16;

Comments [?]

CATALYTIC ACTIVITY Reaction=O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;
CATALYTIC ACTIVITY Reaction=O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit

Keywords [?]

Hydrolase
Protein phosphatase
Metal-binding

Gene Ontology [?]

GO:0046872; Molecular function:metal ion binding

Cross-references [?]

PROSITE PS01032; PPM_1; 1;

Features [?]

From: PS51746
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PPM-type phosphatase #"

Additional information [?]

Size range 96-574 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]