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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01082


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PURL: https://purl.expasy.org/prosite/rule/PRU01082
General rule information [?]

Accession PRU01082
Dates 04-FEB-2015 (Created)
03-SEP-2024 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51746; PPM_2
Name PPM-type phosphatase domain
Function The 300-residue protein phosphatase Mg(2+)- or Mn(2+)-dependent (PPM)-type phosphatase domain that catalyzes the dephosphorylation of phosphoserine- and phosphothreonine-containing protein.
Scope(s) Eukaryota
Bacteria
Viruses
Mimivirus
Example(s) Q7XR06;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=3.1.3.16;

Comments [?]

CATALYTIC ACTIVITY Reaction=O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;
CATALYTIC ACTIVITY Reaction=O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit

Keywords [?]

Hydrolase
Protein phosphatase
Metal-binding

Gene Ontology [?]

GO:0046872; Molecular function:metal ion binding

Cross-references [?]

PROSITE PS01032; PPM_1; 1;

Features [?]

From: PS51746
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PPM-type phosphatase #"

Additional information [?]

Size range 96-574 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]