We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01083
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01083
General rule information
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| Accession | PRU01083 |
| Dates | 13-FEB-2015 (Created)
25-APR-2024 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51747; CYT_DCMP_DEAMINASES_2 |
Name | Cytidine and deoxycytidylate deaminases domain |
| Function | Fill in |
| Scope(s) |
Eukaryota Bacteria Archaea Methanopyrus |
| Example(s) | Q6P6J0; |
Propagated annotation
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Keywords
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| Metal-binding | |
| Zinc | |
| end case | |
| case <FTGroup:1> | |
| Hydrolase | |
| end case | |
Gene Ontology
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| case <FTGroup:1> or <FTGroup:2> | |
| GO:0008270; Molecular function:zinc ion binding | |
Cross-references
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| PROSITE | PS00903; CYT_DCMP_DEAMINASES_1; 1-2; |
Features
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| From: PS51747 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="CMP/dCMP-type deaminase #" | |||||||||
| case <Feature:PS51747:54=E> and not <AnyFeature:MF_00972> | ||||||||||||
| ACT_SITE | 54 | 54 | /note="Proton donor" | E | 1 | |||||||
| BINDING | 52 | 52 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
[HC] | 1 | |||||||
| BINDING | 82 | 82 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
C | 1 | |||||||
| BINDING | 85 | 85 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
C | 1 | |||||||
| else case not <AnyFeature:MF_00972> | ||||||||||||
| BINDING | 52 | 52 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
[HC] | 2 | |||||||
| BINDING | 82 | 82 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 2 | |||||||
| BINDING | 85 | 85 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 2 | |||||||
| end case | ||||||||||||
Additional information
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| Size range | 30-176 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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