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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01101


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01101
General rule information [?]

Accession PRU01101
Dates 22-JUL-2015 (Created)
19-NOV-2022 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51765; ZF_RAG1
Name Zinc finger RAG1-type
Function The dimerization domain of RAG1 proteins consists of a zinc C3HC4 RING finger and a C2H2 zinc RAG1-type finger.
Scope(s) Eukaryota
Euteleostomi
Example(s) Q91829;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

GO:0042803; Molecular function:protein homodimerization activity
case <Feature:PS51765:5=[CH]> and <Feature:PS51765:10=[CH]> and <Feature:PS51765:22=[CH]> and <Feature:PS51765:26=[CH]>
GO:0008270; Molecular function:zinc ion binding
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51765
Key From To Description Tag Condition FTGroup
case <Feature:PS51765:5=[C]> and <Feature:PS51765:10=[C]> and <Feature:PS51765:22=[H]> and <Feature:PS51765:26=[H]>
ZN_FING from to /note="RAG1-type #"
else case <Feature:PS51765:5=[CH]> and <Feature:PS51765:10=[CH]> and <Feature:PS51765:22=[CH]> and <Feature:PS51765:26=[CH]>
ZN_FING from to /note="RAG1-type #; atypical"
else
ZN_FING from to /note="RAG1-type #; degenerate"
end case
BINDING 5 5 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH]
BINDING 10 10 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH]
BINDING 22 22 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH]
BINDING 26 26 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH]

Additional information [?]

Size range 20-40 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]