ProRule PRU01129
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01129 |
| Accession | PRU01129 |
| Dates | 5-APR-2016 (Created)
19-NOV-2022 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51793; MIS18 |
Name | Mis18 domain |
| Function | The oligomerization of Mis18, mediated by its conserved N-terminal globular domain, is crucial for its centromere localization and function. |
| Scope(s) |
Eukaryota |
| Example(s) | A5D7N9 (MS18A_BOVIN); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the mis18 family. |
Keywords
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| Metal-binding | |
| Zinc | |
| end case | |
| Centromere | |
| Chromosome | |
Gene Ontology
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| GO:0000775; Cellular component:chromosome, centromeric region | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
Features
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| From: PS51793 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Mis18 #" | |||||||||
| BINDING | 6 | 6 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 9 | 9 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 63 | 63 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 66 | 66 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 87-110 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [10] All [ 10 ]
- Retrieve set of proteins with 3D structure for this domain