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annotation rule: PRU01129

General rule information [?]

Accession PRU01129
Dates 5-APR-2016 (Created)
22-NOV-2019 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51793; MIS18
Name Mis18 domain
Function The oligomerization of Mis18, mediated by its conserved N-terminal globular domain, is crucial for its centromere localization and function.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the mis18 family.

Gene Ontology [?]

GO:0000775; Cellular component: chromosome, centromeric region.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Metal-binding
Zinc
end case

Centromere
Chromosome

Features [?]

From: PS51793
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Mis18 #        
METAL     6     6       Zinc     C   1
METAL     9     9       Zinc     C   1
METAL     63     63       Zinc     C   1
METAL     66     66       Zinc     C   1

Additional information [?]

Size range 87-110 amino acids
Related rules None
Repeats 1
Topology Undefined
Example A5D7N9 (MS18A_BOVIN)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]