PROSITE entry PS51793
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General information about the entry
| Entry name [info] | MIS18 |
| Accession [info] | PS51793 |
| Entry type [info] | MATRIX |
| Date [info] |
01-APR-2016 CREATED;
13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51793 |
| Associated ProRule [info] | PRU01129 |
Name and characterization of the entry
| Description [info] | Mis18 domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=100; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=95; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6446862; R2=0.0087206; TEXT='-LogE'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=16942.8417969; R2=3.3786802; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=959; H_SCORE=20183; N_SCORE=11.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=443; H_SCORE=18440; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-40; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='P'; M= -14, 81, -3, -88,-103, -99, -98, -14, -94, -12, -17, -95, 98, 19,-101, -6, -28, -45,-112,-103; /M: SY='M'; M= 23, 22, -39, -27, 36, -26,-101, 38, -15, 24, 42, -99,-105, -97,-100, -50, -88, 34,-101, -84; /M: SY='V'; M= -42, -98,-110,-105, -84,-112,-112, 42, -29, -38, -73,-103,-106,-104,-103, -93, 14, 94,-114, -91; /M: SY='F'; M=-102,-101,-117,-112, 115,-114, -99, -14,-108, 20, -75,-108,-115,-115,-106,-104, -95, 4, -77, -56; /M: SY='Q'; M= -89, 1, -86, -20,-105, -97, 13, -49, -75, -8, -85, -15, -98, 122, -76, 6, -89,-100,-102, -4; /M: SY='C'; M= -91, 156,-108,-109,-102,-106,-109,-108,-104, -99, -99, -15,-121,-112, -41, -93, -91, -96,-130,-111; /M: SY='K'; M= 35, -28, -47, -21,-102, 11, -91, -21, 45, -17, -90, -27, -98, 13, 36, 32, -30, -42,-106, -96; /M: SY='N'; M= -17, -19, -83, -42,-104, 18, 58,-105, 24,-104, -94, 59, -98, 36, 10, 38, 10, -53,-111, -29; /M: SY='C'; M= -91, 158,-111,-111,-101,-107,-111,-108,-107, -99, -99, -97,-122,-115,-113, -94, -91, -96,-131,-112; /M: SY='R'; M= -43,-106, -19, -22, 1, -61, 32, -98, 40, 6, -89, 54,-102, -30, 62, -36, -90, -99, 60, 1; /I: I=-16; MI=0; MD=-40; IM=0; DM=-40; /M: SY='T'; M= 23, -97, -91, -40, -97, -39, -93, -86, -11, -4, -86, 12, -97, -32, 40, 13, 68, 17,-111, -95; /M: SY='I'; M= -91,-105,-112,-107, -6,-115,-112, 85,-105, -18, -71,-107, 42,-105,-109,-100, -86, 60,-106, -88; /M: SY='L'; M= -48, -99,-114,-108, 6,-115,-106, 43,-107, 63, -65,-110,-110,-104,-106,-102, -88, 61,-104, -84; /M: SY='G'; M= 38, -6, -93, -98,-107, 79, -98, -41, -95,-106, -99, -82, -97, -91,-101, 45, 5, -97,-107,-103; /M: SY='D'; M= -98,-111, 123, -62,-116, -95, -84, -21, -86,-111,-110, -66, -97, -85, -94, -86, -87,-108,-132,-100; /M: SY='S'; M= -73, -93, -86, -88,-103, -37, -91,-100, -87,-104, -98, -75, -93, -81, -92, 103, 60, -92,-113, -96; /M: SY='F'; M= -62, 16,-100, -42, 59,-105, -95, -11, -97, 48, -14, 35,-107, -98, -31, -26, 25, 17, -98, -33; /M: SY='S'; M= 45, -98, -35, -31, -30, -53, 57,-100, -16, -48, -92, -21, -96, 37, -87, 71, 3, -94,-110, -91; /M: SY='W'; M= -50,-106,-114, -45, 32,-110,-102, -14,-103, 59, -9,-112, -24,-101,-104, -59, -96, 4, 121, 22; /M: SY='C'; M= -15, 71, -43, -44, 0,-106,-101, -12, -44, 21, -4, -15,-107, 1,-100, -21, -14, 65,-108, -23; /M: SY='C'; M= 21, 75, 29, 20, -29, 38, 16, -28, -92, -50, -96, 8,-100, -89, -98, 11, -19, -97, 55, -95; /M: SY='S'; M= 14,-101, 2, -5, -23, -38, 17, 3, -88, -53, -89, 2, -9, 15, -32, 50, 27, -9, 14, 28; /M: SY='D'; M= -92,-105, 63, 10, -98, -44, 24, -92, 7, 5, -89, 44, -23, 33, -26, -39, 0, 3,-111, 4; /M: SY='E'; M= -30,-104, 36, 60,-104, -98, -87, -19, 6, -56, 4, 13, -95, 41, -8, 22, -8, 10,-112, -96; /M: SY='E'; M= 19,-105, 49, 59,-106, -48, 8, 6, -78,-100, -96, -12, -95, -19, 38, 27, -22, -94,-113, -97; /M: SY='L'; M= -91,-102, -10, -4, 29,-103, -5, -11, -89, 49, -11, -92, -1, -28, 23, 32, 16, -34,-101, -30; /M: SY='N'; M= -89,-103, -2, 12, -96, 25, 0, -92, 22, 32, 5, 37,-100, 9, 22, 22, -87, -44,-108, -93; /M: SY='C'; M= 2, 51, -27, -99, 9, -3, -99, 30, -98, 23, 3, -94, -23, -31,-102, 9, 32, 13,-104, -4; /M: SY='I'; M= -2, -10,-110,-105, 32,-111, 2, 68, -19, 35, 7,-102,-106,-100,-102, -97, -20, 26,-101, -81; /M: SY='T'; M= -40, 17, -99, -99, 16, -43,-100, 16, -95, 1, -80, -27,-101, -97, -44, 19, 69, 45,-106, -11; /M: SY='L'; M= -24, 45,-104, -16, 13,-107, 7, -13,-101, 60, 2, -26,-108, -97,-102, 5, -87, 39,-105, -85; /M: SY='S'; M= -52, 17, 7, -87, 4, -98, 8, -12, 39, -8, -12, -4,-101, -84, 33, 45, 1, 0,-104, 4; /M: SY='S'; M= 18, -9, 3, -43, -28, -25, -90, -96, 27, 6, -90, -5, -26, -83, 4, 67, -12, -92,-106, -15; /M: SY='V'; M= 36, -98, -96, 3, -92, -98, -98, 4, -44, -37, -27, -26,-101, 2, 1, 20, -6, 65,-109, -23; /I: I=-8; MI=0; MD=-19; IM=0; DM=-19; /M: SY='T'; M= -28,-107,-107,-107,-106, -27,-112, -42, -35, -14, -96, -42,-109,-105,-109, 21, 69, 29,-126,-107; D=-8; /I: I=-8; MI=0; MD=-19; IM=0; DM=-19; /M: SY='D'; M=-107,-124, 43, -29,-127, -38, -7,-116, -2,-122,-118, -29, -17, -27,-109, 20, 19, -7,-138,-118; D=-8; /I: I=-8; DM=-19; /M: SY='N'; M= -32,-115, -3, -56, -2, -32,-100, -9, -4,-112,-107, 68,-115, -15, -19, 14, -28, -36,-125,-107; D=-8; /I: I=-8; DM=-19; /M: SY='V'; M= -49, 10,-101,-101, -97, -43,-104, 16, -41, -23, -86, 34, -7, 1,-102, 20, 10, 60,-119,-100; D=-8; /I: I=-8; DM=-19; /M: SY='V'; M= -9,-106, 6, 22, -97,-106,-101, 29, -51, -56, 15, -96,-105, 2, -25, 28, -41, 50,-115, -29; D=-8; /I: I=-8; DM=-19; /M: SY='V'; M= -92, -1,-113,-109, -89,-117,-113, 50, -60, -3, -77, -43,-111, -37, -35, -30, -3, 74,-117, -96; D=-8; /I: I=-8; DM=-19; /M: SY='D'; M= -54, -8, 48, 7,-106, -2, -96, 9, -15, -24, -10, -17, -15, 2, -18, 36, -15, -23,-117,-101; D=-8; /I: I=-8; DM=-19; /M: SY='E'; M= -68,-127, -13, 44,-124, -55,-114,-115, -19, -25, -12,-109, -17, -16, -55,-107, 31, -28,-134,-120; D=-8; /I: I=-8; MI=0; MD=-19; IM=0; DM=-19; /M: SY='W'; M= 31,-114, 3, 29,-113, -2, 31, -48, 7,-112,-106, -25, -21, -92, -24, -9, -27, -45, 53,-103; D=-8; /I: I=-8; DM=-19; /M: SY='E'; M= -10,-104, 21, 47, -13, -98, 1, -20, 20, -58, -91, -27, 22, 24, -9, 6, 27, 0,-108, -32; /M: SY='R'; M= -92, -7, -91, 28, 16,-104, 9, 12, 13, 19, 14, -4, -13, 29, 31, -8, -33, 4,-104, -86; /M: SY='Q'; M= -42,-104, -44, -9, -25, -36, 40, 13, 21, 18, 43, 11,-101, 44, 11, -10, -25, 3,-107, -87; /M: SY='T'; M= -21,-100, 40, -40, 17,-101, -96, 31, -41, 2, 8, -87,-100, -17, -14, 26, 43, 21,-107, -87; /I: I=-15; MD=-37; /M: SY='S'; M= -23, -22, -22, -89, -19, 23, -10,-103, 14, -58, -98, 36, -4, -25, -29, 71, -7, -48,-111, -97; D=-15; /I: I=-15; MD=-37; /M: SY='S'; M= -42, 17, 30, 0,-102, -95, -29, 16, 26, -34, -93, 23, -98, -24, -37, 56, 29, -50,-115, -97; D=-15; /I: I=-15; MD=-37; /M: SY='E'; M= -15,-105, 5, 42,-108, -29, -27,-101, 36,-104, -97, 16, 29, -6, 3, 17, 28, -7,-113,-100; D=-15; /I: I=-15; MD=-37; /M: SY='G'; M= -24,-106, -5, -15,-107, 69, 22, -23, -30, -45, -98, -83, 21, -90, -33, 34, 7,-101,-110,-101; D=-15; /I: I=-15; MD=-37; /M: SY='W'; M= -3, 16, 19, 14, 18, -18, -94, -17, -14, -39, -28, -27, 14, 5, -19, 15, 2, 1, 34, 10; D=-15; /I: I=-15; MD=-37; /M: SY='D'; M= -42,-107, 88, 15, -35, 6, -5,-102, -87, 2, -15, -27, -99, -32, -16, -26, 21,-100,-118, -96; D=-15; /I: I=-15; MD=-37; /M: SY='C'; M= 20, 40, -89, 39, -95, 1, -91, -50, 6, -22, 39, -24, -99, -5, -91, 30, 0, -27,-104, 26; D=-15; /I: I=-15; MD=-37; /M: SY='G'; M= -50,-107, -4, 22,-107, 74, 16, -23, 15, -24, -98, 22, -37, -87, -93, -7, -92,-103,-110,-101; D=-15; /I: I=-15; MD=-37; /M: SY='C'; M= -39, 111, -23, -95, -19, -93, -97,-104, -93,-103,-100, 18,-104, -93, -33, 71, 30, -96,-119,-100; D=-15; /I: I=-15; MD=-37; /M: SY='T'; M= -24, -99, -96, -34, -1, -55, -98, 0, -27, -29, 15, -24, 7, -93, -98, 35, 64, 33,-107, 1; D=-15; /I: I=-15; MD=-37; /M: SY='Y'; M= -8,-108,-104,-104, 50,-106, 27, -29, -99, -33, -81,-100,-112, -95, -97, -11, -94, -22, -70, 115; D=-15; /I: I=-15; MD=-37; /M: SY='S'; M= -28,-103, -20, 1, -24, -98, 20, -17, -87, 0, 5, 20,-103, 31, 6, 47, -84, 20,-103, 34; D=-15; /I: I=-15; MD=-37; /M: SY='P'; M= -24, 7, 31, -28, -4,-101, -94, -36, 5, -2, 16, -45, 51, 9, -17, -3, 28, -45, 48, -9; D=-15; /I: I=-15; MD=-37; /M: SY='L'; M= -97,-102,-114,-108, 26,-117,-102, 44,-105, 73, -8,-109,-112,-103, -16,-104, -16, -10,-101, -82; D=-15; /I: I=-15; MD=-37; /M: SY='R'; M= -17, 33, -93, 7, 19,-101, -8, -93, 13, 4, 2, -27,-101, -33, 41, 29, 36, -54,-104, -12; D=-15; /I: I=-15; MD=-37; /M: SY='C'; M= -30, 154,-111,-110,-103,-107,-111,-109, -33,-101,-100, -98,-121,-113,-111, -94, -92, -97,-131,-113; D=-15; /I: I=-15; MD=-37; /M: SY='C'; M= 26, 32, -20, -20,-103, -34, -17, -5, 19, -48, -93, 14,-101, 22, 16, 25, 21, -39,-111, -23; D=-15; /I: I=-15; MD=-37; /M: SY='G'; M= 3,-109, -92, -41,-113, 46, 32,-109, -3,-110,-101, 29,-103, 44, 8, 17, -11, -29,-115,-102; D=-15; /I: I=-15; MI=-37; MD=-37; IM=-37; DM=-37; /M: SY='C'; M= -93, 153,-109,-110,-103,-107,-109,-110,-103,-101,-101, -8,-122,-112, -16, -95, -92, -98,-131,-112; D=-15; /I: I=-15; DM=-37; /M: SY='N'; M= 5,-105, -9, -28,-110, 28, 43,-110, 28,-109, -98, 56, -99, 49, -13, 32, -85,-106,-113, -97; D=-15; /I: I=-15; DM=-37; /M: SY='S'; M= 29, -99, -44, -22,-102, -22, -12, -96, -9, -29, 18, 30, -98, -6, 14, 51, 36, -32,-112, -97; D=-15; /I: I=-15; DM=-37; /M: SY='V'; M= 4, -7, -4, 38, -94, -22, 5, -4, -94, 1, -85, -96, 40, -92,-100, -47, -8, 49,-111, -13; D=-15; /I: I=-15; DM=-37; /M: SY='V'; M= -42,-102,-114,-109, -80,-114,-108, 59,-107, 48, 14,-108,-109,-104,-108, -21, -88, 60,-109, -89; D=-15; /I: I=-15; DM=-37; /M: SY='G'; M= -25,-108, -14,-104,-114, 103,-102,-121,-100,-117,-107, -82,-100, -98,-108, -81, -99,-114,-106,-109; D=-15; /I: I=-15; DM=-37; /M: SY='R'; M= -95, 7, -96, -84, 37,-106, -88, -23, 58, -24, -17, -88,-103, -77, 90, -37, -92, -47, -99, -84; /M: SY='M'; M= -27, -8, -97, -88, -12,-103, -15, 11, 53, -44, 64, -38, -4, 33, 4, -25, -20, 27, 20, -6; /M: SY='Y'; M= -42,-109,-100,-102, 7,-106, -72, -84, -96, -2, 15, -9, -6, -92, -94, -96, -94, -89, -65, 128; /M: SY='H'; M= -52, 32, -11, -91, -15, -52, 40, 40, 17, -24, -81, -38,-103, 11, 28, -8, -3, 24,-102, 32; /M: SY='T'; M= 10, 42, -3, -4,-103, 4, -18, -99, -88,-100, -7, -80, -7, -86, -30, 61, 69, -92,-114, -98; /M: SY='T'; M= -6, -94, -11, -35, -95, -98, -98, -83, -90, -10, -86, -82, -28, -92, -97, -13, 104, 11,-116, -95; /M: SY='P'; M= -1,-106, -29, -25, -8, -24, 13, -47, -91,-102, -95, 17, 94, -90, -98, 26, 22, -23,-108, -25; /M: SY='P'; M= -7,-107, -31, 40, -97,-100, -90, -2, 8, -12, -88, 5, 57, 7, 39, -13, -87, 0,-105, 6; /I: I=-26; MD=-67; /M: SY='H'; M= 26,-105, 38, 31,-105, -94, 78,-105, -19, -36, -94, -18, -2, 33, -11, 32, -86,-101,-113, -32; D=-26; /I: I=-26; MI=0; MD=-67; IM=0; DM=-67; /M: SY='L'; M= -37,-101,-112,-105, 38,-113, -97, 13, -43, 71, 42,-107,-111, -99, -15,-102, -30, -27, -96, 6; D=-26; /I: I=-26; DM=-67; /M: SY='D'; M= 37,-103, 89, -12,-108, -92, -89, -99, -87, -35, -99, 32, -15, -14, -94, -22, -13, -13,-120,-100; D=-26; /I: I=-26; DM=-67; /M: SY='H'; M= 8,-107, 16, 20, -3, -7, 74, -50, 9, -4, -21, -24, 21, -2, -89, -5, -91, -98, 41, 8; D=-26; /I: I=-26; DM=-67; /M: SY='L'; M= -8, -4,-110,-104, 2,-111, -98, 42, -19, 57, 28,-104,-108, -98, -15, -98, -14, -5, -98, 28; D=-26; /I: I=-26; DM=-67; /M: SY='R'; M= -94, -1, -94, -83,-102,-105, -86, -40, 10, -10, -1, -87,-104, 28, 100, 3, -14, -98,-107, -93; D=-26; /I: I=-26; DM=-67; /M: SY='D'; M= -34, -11, 66, 19, -42, 57, -89,-107, -89, -49, 33, 39, -99, -87, -97, 7, -88,-104,-114,-100; D=-26; /I: I=-26; DM=-67; /M: SY='M'; M= 7, -19, -97, -26, -30, -49, 10, -30, 35, 39, 62, -2,-102, -8, -34, -19, 3, -49,-103, 1; D=-26; /I: I=-26; DM=-67; /M: SY='Y'; M=-101,-106,-106,-105, 89,-110, 1, -2,-100, -28, -20,-101,-111, -10, -98, -97, -14, -84, -69, 102; /M: SY='C'; M= -17, 93, -99, -98, 1, -99,-101, -82, -96, 7, -85, -89,-102, -97,-101, 37, 69, 23,-113, -93; /M: SY='L'; M= -96,-100,-110, -18, 69,-113, -99, 14,-105, 71, -67,-108,-111,-102,-104, -22, -91, -4, -93, -73; /M: SY='D'; M= -18,-104, 65, 16, 31, -96, 30, -49, -14, -97, -95, 16, -99, -37, -46, 24, 13, -97, 32, 47; /M: SY='H'; M= -26, -19, -30, 0, -92,-104, 51, 30, 40, -7, 12, -89,-100, -25, -21, -6, 12, 43,-111, -89; /M: SY='D'; M= -3,-102, 67, 11, -34, -91, -85, -47, 14,-104, -98, 53, -96, 28, -85, 34, 17, -43,-115, -96; /M: SY='C'; M= 24, 49, 11, -33,-102, -48, -10, -99, 34, -8, -30, 23, -99, 14, 19, 44, -19, -95,-111, -96; /M: SY='I'; M= -35, 23,-110,-106, -80, -23,-105, 68, -21, 41, -11,-104,-107,-101,-103, -45, -88, 44,-105, -16; /M: SY='Q'; M= -30, -1, -22, -15, 9, -98, 24, -11, 5, 9, -85, 11, 17, 38, -16, 27, 17, -27,-101, 21; /M: SY='C'; M= -51, 80, -37, -14, -94, -43, -95, -39, -91, -6, -13, -32,-101, -89, -23, 67, 34, 19,-112, -13; /M: SY='Y'; M= -49,-110, -98, -98, -56,-106, 21, -87, -19, -9, -79, -98,-110, 2, -37, -35, -94, -91, -65, 129; /M: SY='Q'; M= -16,-104, 5, 2, -95,-100, -9, -24, -47, -14, 52, -87, -29, 80, -8, -1, 11, 22, 16, -4; /M: SY='L'; M= -26, -99,-107,-100, -28,-110, -97, -9, 6, 73, -2,-103,-108, -96, -32, -97, 12, 18,-100, 10; /I: E1=0; IE=-380; DE=-380;» more |
Post-processing [info]
| COMPETES_HIT_WITH | PS51788; PS51789; PS51790; PS51792 |
Numerical results [info]
| Total number of hits | 10 in 10 different sequences |
| Number of true positive hits | 10 in 10 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | Mis18 |
| Version [info] | 3 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
10 sequences
MIS18_SCHPO (Q9P802), MS18A_BOVIN (A5D7N9), MS18A_HUMAN (Q9NYP9), MS18A_MOUSE (Q9CZJ6), MS18A_OTOGA (B5SNH4), MS18A_PANTR (Q68UT5), MS18A_PLEMO (B1MT51), MS18A_RAT (B2RZC4), MS18B_HUMAN (O43482), MS18B_MOUSE (A2AQ14)» more
|
| PDB [Detailed view] |
4 PDB
5HJ0; 5J6P; 7SFY; 7SFZ |