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Entry: PS51788

General information about the entry

Entry name [info] CULT
Accession [info] PS51788
Entry type [info] MATRIX
Date [info] 01-JAN-2016 CREATED;
10-MAY-2017 DATA UPDATE;
13-NOV-2019 INFO UPDATE.
PROSITE Doc. [info] PDOC51788
Associated ProRule [info] PRU01124

Name and characterization of the entry

Description [info] CULT domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=108;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=103;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7562752; R2=0.0085534; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=16484.3242188; R2=6.7289991; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1140; H_SCORE=24155; N_SCORE=12.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=438; H_SCORE=19432; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-26; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='E';  M= -29,  23,  -3,  27, -11, -13, -37,   7, -12, -19,  26,  -2,  -4, -20,  -4,   8, -30,  -7, -81, -27;
/M: SY='D';  M= -25, -24,  41,   4, -14,   2, -35, -31, -19, -66, -50,   9, -10,  -1, -18,  22,  25, -32, -82,  -1;
/M: SY='S';  M=   9, -76, -17,  -5,   5, -31, -67, -15, -31,  -6, -60, -10, -36,  10,  -5,  16,  11,  13,  -2,   9;
/M: SY='L';  M= -70, -13, -88, -82,  34, -63, -76,  38, -39,  58,   9, -83, -36, -77, -78, -78, -66,   6, -71, -25;
/M: SY='C';  M= -12,  52, -76, -69, -18, -66,  -5, -17,   7,  36, -51, -45, -81, -19,  36, -55, -16,  10, -79,  -9;
/M: SY='C';  M= -65, 146, -83, -81, -75, -80, -83, -58, -25, -72, -27, -70, -93, -42, -82, -67, -40, -69,-102, -84;
/M: SY='R';  M=  24, -45, -30, -42, -26, -21, -22, -30,  16, -73, -30, -39, -74,  -5,  76,   1, -29, -50, -79, -35;
/M: SY='H';  M=  -8, -17, -11, -12,   5,  -3,  56, -48, -23, -39,  16,   5, -74,  27,  28,   2,   0, -44, -11,  -5;
/M: SY='C';  M= -46, 146, -83, -84, -75, -79, -82, -80, -79, -71,  -5, -27, -94, -86, -86, -53, -64, -69,-104, -84;
/M: SY='G';  M= -28, -80,   3, -43, -80,  67,  -4, -42,  -9, -36, -25,   7, -73,  27,  11, -17, -33, -77, -81, -51;
/M: SY='H';  M=  39,  -7, -50,   2, -27, -21,  45, -15, -62,  -7, -60,   3, -72, -21, -12,  19,  17, -30, -83, -36;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='P';  M= -16,  -6,  20,  20, -26, -63,  18, -25, -28,  -3, -63,   2,  50,  -3,  12, -20,   2, -24, -84, -50;
/M: SY='I';  M= -65,  -8, -87, -57,  -5, -91, -84,  75, -64,  16, -30, -80, -81, -51, -81, -74, -36,  47, -79, -60;
/M: SY='T';  M=  56,  20, -49, -65, -30,  -5, -71, -69, -33, -72, -67, -58, -69, -63, -32,  23,  61, -50, -84, -71;
/M: SY='W';  M= -25, -79,  25, -36, -25, -56,  38, -75,  14, -63, -68,  26, -29,  18,  36,  25,   0, -29,  42, -30;
/M: SY='K';  M=   1,  14, -38, -14, -44, -18,  12,  -3,  20, -34,   4, -20,  12,  -1,  16,  13, -16, -14, -77,  15;
/M: SY='S';  M=  -5, -11,   8, -12, -57, -15,  -8, -78,   8, -45, -70,  26, -72,   3,  36,  50, -16, -60, -18, -45;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='D';  M= -12, -81,  75,  18, -31, -69,  32, -78, -23, -42, -14,  21, -72,   1, -44, -18, -48, -77,  49,  13;
/M: SY='I';  M= -10, -44, -80, -57,  -9, -66, -71,  42, -41,  29,  37, -74, -79, -22,  15, -24, -42,  29, -75,   0;
/M: SY='F';  M= -55, -75, -82, -53,  59, -84,  -7,  47, -61,  12,  25, -30, -42, -40, -47, -43, -34,  35, -68, -20;
/M: SY='S';  M=  -1,  23,   7,  -8, -29, -26,   1, -27, -13, -39, -65,  39,  12,  -6, -11,  40, -22,  -2, -85, -43;
/M: SY='M';  M= -30, -15, -77, -30, -27, -55, -17,  19,  -8,  21,  84, -43, -22, -65,  -7, -43, -20,  30, -79, -60;
/M: SY='S';  M= -14, -75, -29, -35,  -6,  -7,  25, -38, -30, -60, -35,  40,  25,   3,  10,  51, -17, -54, -78,   5;
/M: SY='S';  M=  -8, -42,  34,   2, -57,  36, -39, -64, -22, -55, -35,   5, -48, -16, -35,  53,   7, -60, -85, -72;
/M: SY='E';  M=   9, -18,  30,  42, -79, -31, -21, -63, -16, -37, -68, -44,  30,   9,  -1,  18,   6, -25, -84, -48;
/I:         I=-15; MD=-37;
/M: SY='H';  M= -24, -80,  -1,   3, -16,  56,  59, -78, -20, -34, -22, -56, -38, -29, -68,  13, -42, -41,  -6, -11; D=-15;
/I:         I=-15; MD=-37;
/M: SY='P';  M=  25, -85, -78, -73, -61, -19, -40, -33,  -5, -79, -74, -28,  51, -36, -77,  -3,   4,  11, -93, -83; D=-15;
/I:         I=-15; MI=0; MD=-37; IM=0; DM=-37;
/M: SY='V';  M= -17,  22, -31, -14, -33, -27, -22,  18, -48,   5,   9, -47, -38,  13, -35,  19,  20,  32, -83, -65;
/M: SY='H';  M= -12, -79, -62, -57, -41,  33,  77, -75, -17, -63,  -9, -39, -72,  65, -37,  19, -22, -40, -76,  19;
/M: SY='T';  M=  26, -22, -67, -26, -21, -68,  -7,   8, -33,   8,  -2,  -3, -71, -43, -68,  21,  45,  14, -79, -14;
/M: SY='F';  M= -12, -42, -79, -77,  82, -80,  21, -51, -72,  -1,  24, -47, -39, -72, -31, -70, -66, -12, -48,  75;
/M: SY='V';  M= -11,   8, -28, -25,  23, -78, -39,  -7,   3, -47, -54, -51, -21, -18, -27, -24,  10,  66, -80, -60;
/M: SY='N';  M= -48, -71, -10, -60, -78, -27, -13, -55, -28, -42, -70, 114, -76, -54, -60, -49, -34, -51, -96, -73;
/M: SY='P';  M=  -8, -13, -66, -39, -84, -51, -69, -75, -64, -42, -70,  -2, 108,  -9, -73,  15, -58, -76, -83, -81;
/M: SY='H';  M=  14, -30, -26, -51,   3,   6,  84, -44, -62, -10, -26,   5, -73,  31, -47,  26, -40, -55, -24, -10;
/M: SY='G';  M= -21, -79, -15, -43, -82,  87,  -4, -86, -25, -38, -73, -38, -49, -14, -30, -28, -46, -81, -79, -76;
/M: SY='Y';  M= -27,  28, -23, -37,  25, -37,  22,  19, -40, -30,   3, -16, -18, -11, -20, -15, -44,  20,  25,  57;
/M: SY='V';  M= -26, -75, -23,  16, -24, -43, -23,  21, -34, -29, -25, -66, -22,  23,  14, -16,  -9,  53, -79,  -6;
/M: SY='H';  M= -50,  -3, -41, -35,  84, -78,  95, -41, -50, -55, -25, -62, -79,  17, -64, -44, -68, -66, -59,  34;
/M: SY='E';  M= -48, -47,  43,  73, -83, -60,  14, -83, -36, -68, -71,   5, -65,  40,  25, -21, -12, -78, -85, -45;
/M: SY='M';  M= -61, -72, -80, -77,  -4, -53, -75,  49, -74,  24,  52, -72, -38, -72, -76, -32,  31,  42,  -5, -27;
/M: SY='V';  M=  21, -71, -77, -51,  -7,   4, -73,  32, -69,  17,  33, -50, -76, -46,  -9, -30, -15,  39, -30, -60;
/M: SY='T';  M= -12,  68, -65, -47, -70,  -8, -70, -63, -58, -25, -62, -56, -34, -64,  20, -23,  85, -18, -87, -70;
/M: SY='F';  M=  -7,  31, -82, -77,  74, -79, -73, -41, -75,  16,  -9, -74, -81, -37, -75, -29,  -1,  48, -65, -20;
/M: SY='S';  M=   8, -41, -31, -11, -51, -54,  22, -22,  39, -37, -63,   1, -70,  14,  29,  40, -20, -48,  -8,  16;
/M: SY='N';  M=   4, -32,  -2,   9, -30, -22,   5, -69,  19, -24, -64,  38,  10,  28,  16,  -6,  16, -23, -82, -66;
/I:         I=-29; MD=-75;
/M: SY='A';  M=  67,  12, -74, -50, -69, -53, -75,  10, -29, -21, -20, -37, -46, -66, -59, -20,  -1,  20, -82, -42; D=-29;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='D';  M= -18, -82,  35,   4, -54, -62,  12, -57, -20, -76, -29,   8,  29,  22,  16,  -1,  16, -12, -88, -21; D=-29;
/I:         I=-29; DM=-75;
/M: SY='N';  M= -23, -39,  11, -33, -40,  50,  13, -57, -22, -31, -66,  58, -71, -18, -13,  12,   4, -12, -83, -68;
/M: SY='C';  M= -19,  76, -78, -30,  -1, -79, -41,   2, -72,  42, -22, -73, -81, -71, -46, -13, -11,  33, -74,  20;
/M: SY='A';  M=  35, -71, -23, -31, -35,  -4, -14,  -3,   5, -13,   0, -24, -40,  -6,  19,  22, -15,  12, -26, -49;
/M: SY='L';  M= -20,   9, -72, -35,   5, -31,   8,   7, -25,  35, -22, -50,  14,   7, -11, -14,   8,   4,  18,  12;
/M: SY='H';  M=  -2, -75,   0,  21, -17, -51,  28,  16, -22, -27, -20, -49, -52,  -2,  20,   1,   3,  24,   1,   7;
/M: SY='G';  M= -38, -77, -14, -23, -28,  76,  25, -65, -49, -58, -71, -52, -11, -10, -12,  15,   9, -77, -79, -70;
/M: SY='P';  M=  -2, -78,   6,  32, -73, -31, -23, -71,   3, -28, -18,  20,  37,  22,  26,   2, -11, -39, -78,   7;
/I:         I=-6; MI=0; MD=-15; IM=0; DM=-15;
/M: SY='P';  M=  -5, -89, -41, -18,  -6, -61, -73, -44, -66, -61, -71, -75,  91, -68,  -2, -24, -39, -52,  74,  12; D=-6;
/I:         I=-6; DM=-15;
/M: SY='S';  M= -22,  -7, -13,   3, -40, -62,   6, -35, -58, -52, -64,  -6, -67,  21, -63,  69,  41, -17, -80,   8;
/M: SY='T';  M=   5, -42,  -4,   9, -32, -21, -37, -40,   9,  -9, -12, -12,  29, -18, -34,  14,  50, -41, -79, -14;
/M: SY='E';  M=   5, -12,  23,  69, -44, -59,  29, -56,  14, -74, -68, -54, -64,  33, -19, -19,   7, -51, -82, -43;
/M: SY='H';  M=  -8, -24,  37, -60,  57, -59,  83, -68, -40, -62, -13,   0, -77, -27, -39, -20, -64, -46, -63,  56;
/M: SY='S';  M= -48,   6, -28, -61, -74, -43, -64, -70, -60, -54, -69, -25, -66, -56, -66,  85,  62, -43, -87, -69;
/M: SY='W';  M= -77, -94, -96, -48,  44, -78, -91, -68, -75, -34, -69, -23, -83, -75, -77, -81, -83, -54, 162,  -3;
/M: SY='F';  M= -78, -76, -87, -84, 112, -59, -67, -34, -80, -46, -54, -41, -34, -87, -77, -76, -70, -58,  -4,  36;
/M: SY='P';  M= -23, -87,  19,  14, -43, -71, -22, -73, -26, -79, -24, -65, 101, -19, -32, -20, -37, -28, -83, -77;
/M: SY='G';  M= -54, -80,  20, -29, -86,  92, -71, -93, -68, -88, -79, -37, -45, -66, -26, -37, -69, -86, -80, -79;
/M: SY='Y';  M= -43, -83, -74, -76,  33, -56,  14, -26, -69, -45, -31, -73, -33, -66, -42, -44, -46, -63, -37, 118;
/M: SY='A';  M=  50,  -8, -12,  13, -45, -19, -19, -25, -15, -40, -38,   8, -70,   5, -16,  33, -27, -44, -81, -31;
/M: SY='W';  M= -75, -98, -97, -78, -47, -75, -96, -75, -24, -36, -74, -90, -41, -71, -37, -10, -83, -86, 168, -34;
/M: SY='T';  M= -48,  39, -38, -16, -75, -72, -12, -53,  -6, -53, -29,  -2, -70,  49,  46,   5,  60, -47, -84, -31;
/M: SY='I';  M= -34,  30, -11, -48,  17, -82, -46,  63, -73, -13,   2, -28,  14, -73, -45, -33, -41,  28, -75,   5;
/M: SY='C';  M=  47,  67, -77, -46, -63, -40, -50,  30, -72,  13, -10, -70, -77, -69, -48, -15, -22,  10, -81, -23;
/M: SY='V';  M= -16,  -2, -68, -30,  -4, -74,  16,   1, -39,  14,  -1,  14, -76,   9,  -2,  16,   3,  28, -77,   7;
/M: SY='C';  M= -64, 144, -43, -51, -43, -79, -82, -78, -78, -70,  -8, -70, -32, -84, -84, -38, -64, -49,  -5, -80;
/M: SY='P';  M=  16,  31, -63, -26, -44,  -6, -64, -51,  16, -34, -35,  16,  42, -35,  27,  27, -13, -51, -81, -33;
/M: SY='R';  M= -10, -12, -23, -60, -18,  -2,   3, -34,  11, -46, -44,  24, -73,  -2,  45,  32,   5, -25, -80, -16;
/M: SY='C';  M= -65, 144, -84, -83, -30, -47, -83, -51, -50, -40, -69, -71, -93, -86, -84, -46, -64, -46, -99, -81;
/M: SY='G';  M=  -7, -77, -19, -28, -30,  42,  30, -75,  -2, -37,   6,  -8, -71,  15,  20,  27, -10, -72,  23,  -8;
/M: SY='S';  M=   7, -72,   0, -23, -21,  -8,  17, -56, -21, -27, -64,  33, -71,   0,  16,  39,  24, -22, -30, -25;
/M: SY='H';  M= -71, -81, -23, -59,  39, -74, 126, -50, -63, -23, -56,  -3,  -5,   9, -59, -40, -68, -76, -85, -41;
/M: SY='L';  M= -66, -21, -81, -40, -50, -85, -10,  39, -50,  61,  32, -24, -81, -70, -34, -33, -62,  21, -78, -58;
/M: SY='G';  M= -19, -78, -68, -77, -82,  94, -73, -84, -70, -65, -22, -54, -71, -69, -35, -28, -68, -34, -77, -78;
/M: SY='W';  M= -77, -34, -49, -57,  -5, -53, -99, -50, -75, -42, -74, -92, -82, -74, -78, -42, -86, -85, 169, -33;
/M: SY='R';  M=   3, -78, -64,   1, -22,  -1,  33, -30,  32, -11,   2, -42, -73,  18,  34, -10, -27, -55, -72,  28;
/M: SY='F';  M= -75, -76, -84, -81, 105, -83,  -8, -54, -45, -48, -55, -76, -45, -81, -24, -34, -68, -18, -45,  54;
/M: SY='T';  M= -13, -39,   5,  36, -21, -59,  -1, -31, -19, -38,  -6, -35, -41,  16,   7,  17,  46, -21, -80,  -7;
/M: SY='P';  M=  30, -20, -22, -40, -77, -19,  46, -60,   4, -76, -67, -29,  54, -24,  10,  27,   2, -47, -82, -21;
/I:         I=-3; MD=-8;
/M: SY='T';  M= -26, -17,  31, -18, -73, -34,  -2,  -8, -46,  -2,  -3,   0, -41, -26, -57, -51,  33,  21, -18, -72; D=-3;
/I:         I=-3; MD=-8;
/M: SY='D';  M= -28, -89,  35,  20, -89, -48, -27, -61,  23, -46, -39,  10, -80,  11,  -7,   9, -48, -64, -94, -38; D=-3;
/I:         I=-3; MI=0; MD=-8; IM=0; DM=-8;
/M: SY='R';  M= -10, -91,   3,   6, -29, -53, -43, -89,  10, -74, -82, -13,  20,  -7,  24,  -1, -13, -63, -94, -81; D=-3;
/I:         I=-3; DM=-8;
/M: SY='C';  M= -20,  37,  12, -15, -40, -22,  25, -51, -43, -42, -75,  23, -42,  13,  -3, -17,  13, -30, -97, -76; D=-3;
/I:         I=-3; DM=-8;
/M: SY='L';  M=  -5, -84, -11, -28, -18, -25, -32, -20, -56,  25,  11, -30,  17, -14,  -1, -21, -11, -45, -86, -48; D=-3;
/I:         I=-3; DM=-8;
/M: SY='S';  M= -28, -45,  -3,   3, -79, -10,  12, -57, -18, -17, -68,  10,  -4,  27,   0,  34,  14, -26, -88, -72; D=-3;
/I:         I=-3; DM=-8;
/M: SY='P';  M= -35, -84,  -6,  -6, -31,   7, -39, -43,  -5, -25, -69, -28,  83, -10, -47,  -5,   0, -42, -83, -75; D=-3;
/I:         I=-3; DM=-8;
/M: SY='H';  M=   6, -27,  -5,   0, -45,   0,  34, -73,  16, -30,  -4, -21,  12,  33,  23,   0,  -6, -43, -82, -48;
/M: SY='S';  M= -31,  26, -32, -28, -29,  14,  -9, -16,  10, -28, -31,  -9, -73,   1,  17,  47,  -6, -13, -82, -47;
/M: SY='F';  M= -77, -25, -50, -85, 109, -59, -72, -22, -80, -38, -56, -48, -89, -88, -48, -32, -70, -27, -50,  -1;
/M: SY='W';  M= -38, -82, -47, -42,  51, -82, -10, -10, -72, -20,  -6, -28, -85, -72, -27, -32, -69,   8,  91,  74;
/M: SY='G';  M=  25,   8, -72, -76, -49,  79, -29, -46, -49, -61, -74, -59, -75, -34, -78, -11, -68, -58, -81, -78;
/M: SY='L';  M= -28, -38, -87, -81,  -4, -88, -77,  41, -35,  62,   2, -82, -85, -76, -79, -50, -26, -13, -77, -40;
/M: SY='I';  M= -28,   0, -77, -72, -46, -82, -74,  58, -17,  -6,  -5, -37, -78, -16,  28,  -8,  26,  -8, -82, -29;
/M: SY='R';  M= -23, -80, -29, -31,  -5, -31, -68, -17,  -4,  35, -33, -69, -47, -17,  53, -19, -10, -29, -78, -32;
/M: SY='D';  M=  -1, -78,  41,   9, -82, -23, -32, -49,   4, -58, -13,  27,  -7,   0, -19,  19,  19, -37, -90, -74;
/M: SY='R';  M=  29, -42, -36, -48, -55, -23,  42, -80, -27, -79, -69,  42, -76,  26,  44,  11, -33, -75, -83,  -2;
/M: SY='L';  M= -32,  28, -85, -51, -43, -88, -28,  38, -78,  52, -43, -81, -85, -20, -51, -75, -25,  26, -81, -23;
/M: SY='V';  M=   0, -77, -42, -30, -49, -39, -30,  23, -10,  -3, -26, -45, -78,  -6,  22, -24,  20,  29, -83, -19;
/M: SY='P';  M= -30, -82,   7,  11,  21, -12, -26, -35, -66, -26, -68, -27,  35, -34, -28,  19,  18, -41,  29,  -2;
/M: SY='E';  M=  -8, -37,   6,  34, -47,  -7, -17, -42,  -5, -67, -25, -34, -33,  11,   5,  19, -20, -23, -89, -51;
/M: SY='K';  M=  -7, -33,  13,  -1, -49, -40,   7, -24,  14, -23, -44,   9, -10, -32, -56,   8,  -2, -19, -92, -51;
/I:         E1=0; IE=-380; DE=-380;
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Post-processing [info]

COMPETES_HIT_WITH PS51789; PS51790; PS51792; PS51793

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2019_10 which contains 561'356 sequence entries.


Total number of hits 20 in 20 different sequences
Number of true positive hits 20 in 20 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] CULT
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
20 sequences

CRBN_BOVIN  (Q0P564    ), CRBN_CHICK  (P0CF65    ), CRBN_DANRE  (Q68EH9    ), 
CRBN_DROAN  (B3M1F2    ), CRBN_DROER  (B3P4M4    ), CRBN_DROGR  (B4JSL2    ), 
CRBN_DROME  (Q9VH36    ), CRBN_DROMO  (B4KCG1    ), CRBN_DROPE  (B4GZ07    ), 
CRBN_DROPS  (Q29B72    ), CRBN_DROSE  (B4HJA7    ), CRBN_DROSI  (B4QVV3    ), 
CRBN_DROVI  (B4M686    ), CRBN_DROWI  (B4N8G7    ), CRBN_DROYA  (B4PVI7    ), 
CRBN_HUMAN  (Q96SW2    ), CRBN_MOUSE  (Q8C7D2    ), CRBN_PONAB  (Q5R6Y2    ), 
CRBN_RAT    (Q56AP7    ), CRBN_XENTR  (Q640S2    )
» more

PDB
[Detailed view]
21 PDB

3WX1; 3WX2; 4CI1; 4CI2; 4CI3; 4TZ4; 4TZC; 4TZU; 5FQD; 5HXB; 5V3O; 5YIZ; 5YJ0; 5YJ1; 6BN7; 6BN8; 6BN9; 6BNB; 6BOY; 6H0F; 6H0G
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View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission