PROSITE logo

ProRule PRU01124


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01124
General rule information [?]

Accession PRU01124
Dates 14-JAN-2016 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51788; CULT
Name CULT (for Cereblon domain of Unknown activity, binding cellular Ligands and
Function The thalidomide-binding region of cereblon is a conserved domain, CULT, carrying several invariant cysteine and tryptophan residues. The nature of the binding pocket, an aromatic cage of three tryptophan residues, suggests a role in the recognition of cationic ligands.
Scope(s) Eukaryota
Metazoa
Example(s) Q56AP7;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51788
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CULT #"
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 73 73 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 76 76 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1

Additional information [?]

Size range 99-120 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]