ProRule PRU01124

General rule information [?]

Accession PRU01124
Dates 14-JAN-2016 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51788; CULT
Name CULT (for Cereblon domain of Unknown activity, binding cellular Ligands and
Function The thalidomide-binding region of cereblon is a conserved domain, CULT, carrying several invariant cysteine and tryptophan residues. The nature of the binding pocket, an aromatic cage of three tryptophan residues, suggests a role in the recognition of cationic ligands.
Scope(s) Eukaryota
Example(s) Q56AP7 (CRBN_RAT);

Propagated annotation [?]

Keywords [?]

end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51788
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CULT #"
BINDING 6 6 /ligand="Zn(2+)"
C 1
BINDING 9 9 /ligand="Zn(2+)"
C 1
BINDING 73 73 /ligand="Zn(2+)"
C 1
BINDING 76 76 /ligand="Zn(2+)"
C 1

Additional information [?]

Size range 99-120 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]