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General rule information [?]

Accession PRU01124
Dates 14-JAN-2016 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS51788; CULT
Names CULT (for Cereblon domain of Unknown activity, binding cellular Ligands and; Thalidomide) domain
Function The thalidomide-binding region of cereblon is a conserved domain, CULT, carrying several invariant cysteine and tryptophan residues. The nature of the binding pocket, an aromatic cage of three tryptophan residues, suggests a role in the recognition of cationic ligands.

Propagated annotation [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

end case

Features [?]

From: PS51788
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       CULT #        
BINDING     6     6       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     9     9       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     73     73       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     76     76       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1

Additional information [?]

Size range 99-120 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q56AP7 (CRBN_RAT)
Eukaryota; Metazoa
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]