PRU01124

General rule information [?]

Accession	PRU01124
Dates	14-JAN-2016 (Created) 19-NOV-2022 (Last updated, Version 8)

Data class

Domain

Predictors

PROSITE; PS51788; CULT

Names

CULT (for Cereblon domain of Unknown activity, binding cellular Ligands and; Thalidomide) domain

Function

The thalidomide-binding region of cereblon is a conserved domain, CULT, carrying several invariant cysteine and tryptophan residues. The nature of the binding pocket, an aromatic cage of three tryptophan residues, suggests a role in the recognition of cationic ligands.

Propagated annotation [?]

Gene Ontology [?]

case <FTGroup:1>

GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Metal-binding
Zinc

end case

Features [?]

From: PS51788

Key From To Description Tag Condition FTGroup

DOMAIN from to CULT #

BINDING 6 6 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 9 9 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 73 73 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 76 76 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

Additional information [?]

Size range	99-120 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q56AP7 (CRBN_RAT)
Scope	Eukaryota; Metazoa
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [20]
Retrieve set of proteins with 3D structure for this domain