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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01124


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01124
General rule information [?]

Accession PRU01124
Dates 14-JAN-2016 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51788; CULT
Name CULT (for Cereblon domain of Unknown activity, binding cellular Ligands and
Function The thalidomide-binding region of cereblon is a conserved domain, CULT, carrying several invariant cysteine and tryptophan residues. The nature of the binding pocket, an aromatic cage of three tryptophan residues, suggests a role in the recognition of cationic ligands.
Scope(s) Eukaryota
Metazoa
Example(s) Q56AP7;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51788
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CULT #"
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 73 73 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 76 76 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1

Additional information [?]

Size range 99-120 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]