PRU01124
General rule information
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Accession | PRU01124 |
Dates | 14-JAN-2016 (Created) 19-NOV-2022 (Last updated, Version 8) |
Data class | Domain |
Predictors | PROSITE; PS51788; CULT |
Names | CULT (for Cereblon domain of Unknown activity, binding cellular Ligands and; Thalidomide) domain |
Function | The thalidomide-binding region of cereblon is a conserved domain, CULT, carrying several invariant cysteine and tryptophan residues. The nature of the binding pocket, an aromatic cage of three tryptophan residues, suggests a role in the recognition of cationic ligands. |
Propagated annotation
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Gene Ontology
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case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
Keywords
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end case
Features
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From: PS51788 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | CULT # | |||||||||
BINDING | 6 | 6 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING | 9 | 9 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING | 73 | 73 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING | 76 | 76 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 |
Additional information
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Size range | 99-120 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q56AP7 (CRBN_RAT) |
Scope | Eukaryota; Metazoa |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [20]
- Retrieve set of proteins with 3D structure for this domain