ProRule PRU01132
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01132 |
| Accession | PRU01132 |
| Dates | 25-APR-2016 (Created)
19-NOV-2022 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51796; MSS4 |
Name | Mss4 domain |
| Function | Although it was first proposed to function as a guanine exchange factor (GEF) for Rab GTPases, it was soon described as a quite inefficient GEF and was thus suggested to function rather as a chaperone, protecting nucleotide free Rabs from degradation, than as a GEF. |
| Scope(s) |
Eukaryota |
| Example(s) | Q9U1X4 (MSS4_CAEEL); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the DSS4/MSS4 family. |
Keywords
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| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
Features
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| From: PS51796 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="MSS4 #" | |||||||||
| BINDING | 15 | 15 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 18 | 18 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 86 | 86 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 89 | 89 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 76-141 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [7] All [ 7 ]
- Retrieve set of proteins with 3D structure for this domain