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ProRule PRU01132


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PURL: https://purl.expasy.org/prosite/rule/PRU01132
General rule information [?]

Accession PRU01132
Dates 25-APR-2016 (Created)
19-NOV-2022 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS51796; MSS4
Name Mss4 domain
Function Although it was first proposed to function as a guanine exchange factor (GEF) for Rab GTPases, it was soon described as a quite inefficient GEF and was thus suggested to function rather as a chaperone, protecting nucleotide free Rabs from degradation, than as a GEF.
Scope(s) Eukaryota
Example(s) Q9U1X4;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the DSS4/MSS4 family.

Keywords [?]

Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51796
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MSS4 #"
BINDING 15 15 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 18 18 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 86 86 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 89 89 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1

Additional information [?]

Size range 76-141 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]