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PRU01132


General rule information [?]

Accession PRU01132
Dates 25-APR-2016 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51796; MSS4
Name Mss4 domain
Function Although it was first proposed to function as a guanine exchange factor (GEF) for Rab GTPases, it was soon described as a quite inefficient GEF and was thus suggested to function rather as a chaperone, protecting nucleotide free Rabs from degradation, than as a GEF.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the DSS4/MSS4 family.

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Metal-binding
Zinc
end case


Features [?]

From: PS51796
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       MSS4 #        
BINDING     15     15       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     18     18       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     86     86       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     89     89       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1

Additional information [?]

Size range 76-141 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9U1X4 (MSS4_CAEEL)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]