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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01142


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01142
General rule information [?]

Accession PRU01142
Dates 03-JUN-2016 (Created)
19-NOV-2022 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51801; ZF_CCHC_NOA
Name Zinc finger CCHC NOA-type
Function The CCHC NOA (NEMO Optineurin ABIN2)-type zinc finger has been shown to function as an ubiquitin-binding domain.
Scope(s) Eukaryota
Metazoa
Example(s) Q95KA2;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

case <Feature:PS51801:9=[CH]> and <Feature:PS51801:12=[CH]> and <Feature:PS51801:25=[CH]> and <Feature:PS51801:29=[CH]>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51801
Key From To Description Tag Condition FTGroup
case <Feature:PS51801:9=C> and <Feature:PS51801:12=C> and <Feature:PS51801:25=H> and <Feature:PS51801:29=C>
ZN_FING from to /note="CCHC NOA-type #"
else case <Feature:PS51801:9=[CH]> and <Feature:PS51801:12=[CH]> and <Feature:PS51801:25=[CH]> and <Feature:PS51801:29=[CH]>
ZN_FING from to /note="CCHC NOA-type #; atypical"
else
ZN_FING from to /note="CCHC NOA-type #; degenerate"
end case
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 12 12 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 25 25 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 29 29 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 21-43 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]