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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01144


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01144
General rule information [?]

Accession PRU01144
Dates 17-JUN-2016 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51803; ZF_C2HC_RNF
Name Zinc finger C2HC RNF-type
Function The closely related proteins RNF125/TRAC-1, RNF114 (also known as Zpf313), RNF138 (or NARF) and RNF166 contain, apart from the RING domain, a C2HC (Cys2-His-Cys)- and two C2H2 (Cys2-His2)-type zinc fingers, as well as an ubiquitin interacting motif (UIM).
Scope(s) Eukaryota
Euteleostomi
Example(s) Q1L721;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
Zinc-finger
end case

Gene Ontology [?]

case <Feature:PS51803:1=[CH]> and <Feature:PS51803:4=[CH]> and <Feature:PS51803:16=[CH]> and <Feature:PS51803:20=[CH]>
GO:0008270; Molecular function:zinc ion binding
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51803
Key From To Description Tag Condition FTGroup
case <Feature:PS51803:1=C> and <Feature:PS51803:4=C> and <Feature:PS51803:16=H> and <Feature:PS51803:20=C>
ZN_FING from to /note="C2HC RNF-type #"
else case <Feature:PS51803:1=[CH]> and <Feature:PS51803:4=[CH]> and <Feature:PS51803:16=[CH]> and <Feature:PS51803:20=[CH]>
ZN_FING from to /note="C2HC RNF-type #; atypical"
else
ZN_FING from to /note="C2HC RNF-type #; degenerate"
end case
BINDING 1 1 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 16 16 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 20 20 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 10-30 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]