ProRule PRU01144
General rule information
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| Accession | PRU01144 |
| Dates | 17-JUN-2016 (Created)
19-NOV-2022 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51803; ZF_C2HC_RNF |
Name | Zinc finger C2HC RNF-type |
| Function | The closely related proteins RNF125/TRAC-1, RNF114 (also known as Zpf313), RNF138 (or NARF) and RNF166 contain, apart from the RING domain, a C2HC (Cys2-His-Cys)- and two C2H2 (Cys2-His2)-type zinc fingers, as well as an ubiquitin interacting motif (UIM). |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | Q1L721 (RN138_XENLA); |
Propagated annotation
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Keywords
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| Metal-binding | |
| Zinc | |
| Zinc-finger | |
| end case | |
Gene Ontology
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| case <Feature:PS51803:1=[CH]> and <Feature:PS51803:4=[CH]> and <Feature:PS51803:16=[CH]> and <Feature:PS51803:20=[CH]> | |
| GO:0008270; Molecular function:zinc ion binding | |
| GO:0046872; Molecular function:metal ion binding | |
Features
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| From: PS51803 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <Feature:PS51803:1=C> and <Feature:PS51803:4=C> and <Feature:PS51803:16=H> and <Feature:PS51803:20=C> | ||||||||||||
| ZN_FING | from | to | /note="C2HC RNF-type #" | |||||||||
| else case <Feature:PS51803:1=[CH]> and <Feature:PS51803:4=[CH]> and <Feature:PS51803:16=[CH]> and <Feature:PS51803:20=[CH]> | ||||||||||||
| ZN_FING | from | to | /note="C2HC RNF-type #; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | from | to | /note="C2HC RNF-type #; degenerate" | |||||||||
| end case | ||||||||||||
| BINDING | 1 | 1 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 4 | 4 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 16 | 16 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 20 | 20 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
Additional information
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| Size range | 10-30 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [19] All [ 19 ]
- Retrieve set of proteins with 3D structure for this domain