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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01145


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01145
General rule information [?]

Accession PRU01145
Dates 27-JUN-2016 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51804; ZF_C2HC_LYAR
Name Zinc finger C2HC LYAR-type
Function Ly-1 antibody reactive clone (Lyar), which is known to be expressed abundantly in the testis, encodes a nucleolar protein that contain a LYAR- type C2HC zinc finger motif and three nuclear localization signals.
Scope(s) Eukaryota
Example(s) O94311;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

case <Feature:PS51804:6=[CH]> and <Feature:PS51804:9=[CH]> and <Feature:PS51804:21=[CH]> and <Feature:PS51804:25=[CH]>
GO:0008270; Molecular function:zinc ion binding
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51804
Key From To Description Tag Condition FTGroup
case <Feature:PS51804:6=C> and <Feature:PS51804:9=C> and <Feature:PS51804:21=H> and <Feature:PS51804:25=C>
ZN_FING from to /note="C2HC LYAR-type #"
else case <Feature:PS51804:6=[CH]> and <Feature:PS51804:9=[CH]> and <Feature:PS51804:21=[CH]> and <Feature:PS51804:25=[CH]>
ZN_FING from to /note="C2HC LYAR-type #; atypical"
else
ZN_FING from to /note="C2HC LYAR-type #; degenerate"
end case
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 21 21 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 25 25 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 15-36 amino acids
Related rules None
Fusion None
Repeats 2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]