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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01150


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01150
General rule information [?]

Accession PRU01150
Dates 05-AUG-2016 (Created)
22-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51808; CHCH
Name Coiled coil-helix-coiled coil-helix (CHCH) domain
Function Twin CX(9)C proteins are eukaryotic proteins that adopt a coiled coil-helix-coiled coil helix (CHCH) fold stabilized by two disulfide bonds, which are formed by the four cysteines in the twin CX(9)C motifs (i.e., two pairs of cysteines each spaced by nine residues).
Scope(s) Eukaryota
Example(s) Q5RFJ0;

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case
Mitochondrion

Features [?]

From: PS51808
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CHCH #"
MOTIF 4 14 /note="Cx9C motif #" C-x(9)-C
MOTIF 4 14 /note="Cx10C motif #" C-x(10)-C
MOTIF 25 35 /note="Cx9C motif #" C-x(9)-C
MOTIF 25 35 /note="Cx10C motif #" C-x(10)-C
DISULFID 4 35 disulf C-x*-C
DISULFID 14 25 disulf C-x*-C

Additional information [?]

Size range 24-67 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]