ProRule PRU01150

General rule information [?]

Accession PRU01150
Dates 5-AUG-2016 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51808; CHCH
Name Coiled coil-helix-coiled coil-helix (CHCH) domain
Function Twin CX(9)C proteins are eukaryotic proteins that adopt a coiled coil-helix-coiled coil helix (CHCH) fold stabilized by two disulfide bonds, which are formed by the four cysteines in the twin CX(9)C motifs (i.e., two pairs of cysteines each spaced by nine residues).
Scope(s) Eukaryota
Example(s) Q5RFJ0 (COA5_PONAB);

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

Features [?]

From: PS51808
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CHCH #"
MOTIF 4 14 /note="Cx9C motif #" C-x(9)-C
MOTIF 4 14 /note="Cx10C motif #" C-x(10)-C
MOTIF 25 35 /note="Cx9C motif #" C-x(9)-C
MOTIF 25 35 /note="Cx10C motif #" C-x(10)-C
DISULFID 4 35 disulf C-x*-C
DISULFID 14 25 disulf C-x*-C

Additional information [?]

Size range 24-67 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]