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| Entry: PS51808 |
General information about the entry
| Entry name [info] | CHCH |
| Accession [info] | PS51808 |
| Entry type [info] | MATRIX |
| Date [info] |
01-AUG-2016 CREATED;
01-AUG-2016 DATA UPDATE; 07-OCT-2020 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51808 |
| Associated ProRule [info] | PRU01150 |
Name and characterization of the entry
| Description [info] | Coiled coil-helix-coiled coil-helix (CHCH) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=43; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=43; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5089412; R2=0.0082775; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=966; N_SCORE=10.5; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=483; N_SCORE=6.5; MODE=1; TEXT='R?'; /DEFAULT: M0=-49; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='H'; M= -2, 19, -4, -19, -4, 14, 40, -72, 5, -56, 7, -30,-105, 26, 35, 2, 35, -54, -1, 10; /M: SY='D'; M= 4, 19, 33, -6,-195, 30, -13, -55, 24,-192, -18, 18, 26, 32, 16, 13, -26,-106,-198,-186; /M: SY='P'; M= 1,-196, 3, 35,-188, -31, 28,-185, -23, -80, -68, 3, 76, 20, 21, -38, -47, -3,-192, 22; /M: SY='C'; M=-178, 162,-198,-198,-189,-194,-198,-195,-194,-186,-186,-184,-209,-202,-201,-181,-178,-183,-218,-199; /I: I=-45; MI=0; MD=-115; IM=0; DM=-115; /M: SY='W'; M= 29,-190, 6, -31, -8, 14, 5, -76, 5, 0, 29, -7, 0, 26, -87, 1, -16, -33, 61, 0; /M: SY='E'; M= -10,-194, 31, 60, -17, -50, 38, -63, 27,-101, -25, -28, 14, 39, -32, -20, -38, -11,-193, -1; /M: SY='E'; M= -15,-192,-169, 74, 19, -78, 7, -85, -82, 18, -37, -10, 31, 23, -46, -9, -16, -44,-189, -3; /M: SY='M'; M= 0, -26,-183, -37, 53, -25, -3, 21, 15, -14, 55, 33,-191, 9, 6, -47, -83, -35, 19, 8; /M: SY='K'; M= -9, 31, 25, 16, -69,-186, -25, -7, 60, -15, 11, -11,-185, 19, 21, -12, -7, -34,-196,-181; /M: SY='A'; M= 54,-189, 23, 44, -51,-179,-176, -37, 10, -30, -20, 6, -59, 48, -6, 8,-115, -81,-195,-183; /M: SY='Y'; M= -2,-191,-193,-188, 70,-192, -25, 15,-184, 21, -16,-188, 11, -43, -15, 5,-178, -84, 26, 79; /M: SY='M'; M= -56,-192, 22, -8, 27, -25, 38, -6, -18, 32, 56, -23,-190, 43, -48, -47, -27, -25, 47, -55; /M: SY='Q'; M= -33,-193, 30, 44,-192, -39, -81,-191, 53, -21,-181, 0,-182, 54, 30, 3, -1,-187,-195, -41; /M: SY='C'; M=-178, 162,-198,-198,-189,-194,-198,-195,-194,-186,-186,-184,-209,-202,-201,-181,-178,-183,-218,-199; /M: SY='M'; M= -6, -38,-191, -87, 31,-193, 43, 16, -9, 41, 49,-184,-193, -1, 11, -28, -83, -13, 46, 23; /M: SY='W'; M= -12,-192, 17, -8, -73,-185, 25, -65, 59, -44, -18, -5,-185, 34, 27, -3, 7, -3, 64, -42; /I: I=-18; MD=-45; /M: SY='E'; M= 3,-195, 32, 61, -47, -35, -26,-192, -8, -45, -71, 20,-185, 24, 10, 3, -28,-113,-192, 35; D=-18; /I: I=-18; MD=-45; /M: SY='N'; M= -65, -49, -24, -2, -24, -21, 48, -40, 24,-188, -1, 87, -48,-169, -49, 21, 4, -67, 29, -2; D=-18; /I: I=-18; MD=-45; /M: SY='Q'; M= -41,-195, -24, 19, -4, 45,-177,-193, 2, -85, -63, 36, 26, 50, -21, -28, 18,-190,-191, 8; D=-18; /I: I=-18; MD=-45; /M: SY='Y'; M= -1,-195, 26, 38, -15, -1, 30, -2, -63, -71, -16, 17, -19, 26, -42, 5, -79, -65,-187, 55; D=-18; /I: I=-18; MD=-45; /M: SY='D'; M= -44,-196, 61, 39, -23, -34,-176, -64, -4, -14, 7, 26, 29, 22, -26, -2, -49, -91, 22,-183; D=-18; /I: I=-18; MD=-45; /M: SY='W'; M= -31,-196, -2, 14, 10, -28,-182, -37, 28, -30, -40, 10, 28, -55, 43, -28, -18, 6, 46,-179; D=-18; /I: I=-18; MD=-45; /M: SY='W'; M= 11,-198, 5, -1, 15, 9, -28, -15, 16, -22, -25, -40, -18, -49, -42, 15, -38, -39, 26, -64; D=-18; /I: I=-18; MI=0; MD=-45; IM=0; DM=-45; /M: SY='K'; M= 1,-192, 27, 25, -66,-185, 33,-181, 48, 12, -3, 21, 5, 19, 11, -50, -51, -45,-194, -10; /M: SY='C'; M=-178, 162,-198,-198,-189,-194,-198,-195,-194,-186,-186,-184,-209,-202,-201,-181,-178,-183,-218,-199; /M: SY='R'; M= 2,-190, -10, 26, -52, -44, 7, -16, 24, 4, -36, 19,-185, 3, 42, 18, 17, -42,-196,-180; /M: SY='E'; M= 1,-193, 45, 48,-188, 0, 13, -33, 45, -51,-182, 3, -20, -21, -14, -26, -32, -57, 4, 9; /M: SY='E'; M= -54, -79,-177, 60, 42,-106, 1, -47, 5, 44, -17,-112,-189, 31,-176,-181,-180, -33, 34, 37; /M: SY='F'; M= 1,-191, -14, -60, 54, 2, -26, 24, 2, -65, 40, 11,-189, 34, 15, 2,-175, -17, 19, -27; /M: SY='K'; M= -31,-194, 40, 39,-189, -72, 7,-118, 50, -88, 24, -40,-183, 32, 41, -17, -2, -31, 2, -4; /M: SY='A'; M= 53, -35, 35, 32, -97, -70, -63, -43, 6, -9,-176, -50,-184, 13, -9, 10, -22, 0,-196, -40; /M: SY='Y'; M=-185,-191,-197,-193, 71,-198, 11, -39,-189, 30, 58,-192,-199,-187,-187,-188,-180, 24, 32, 89; /M: SY='K'; M= -50,-193, -7, 0, 0, -96, -27, -38, 52, 5, 17, 27,-188, 29, 47, -96, -11, -58, 3, 15; /I: I=-45; MI=0; MD=-115; IM=0; DM=-115; /M: SY='Q'; M= -47,-194, 27, 51,-190, -51, -2, -33, 46, -10, -83, 13,-183, 54, 16, -7, -63, -69,-195, -38; /M: SY='C'; M=-179, 161,-199,-199,-189,-194,-199,-196,-195,-187,-187,-185,-210,-202,-201,-182,-179,-184,-219,-200; /M: SY='C'; M= 9, 41,-187, -25, -4,-190,-185, -72, 34, 17, 25,-182, 27, -77, 24, -52, 7, 31, 31,-177; /M: SY='R'; M= -22,-191, -89, 15, -51, -78, 15, -55, 32, 20, 34, -15,-187, 17, 40, 27, -2, -51,-190, 10; /M: SY='K'; M= 0,-193, 39, 36, -26, -20, -4,-194, 48, -87, -81, -29,-183, 37, 22, 35, -67,-189,-194, -26; /M: SY='W'; M= 6,-194, -8, 2, 31,-188, 48, -29, -19, -25, -3, 14,-191, 0, -15, -37, -34, -17, 104, 46; /M: SY='Y'; M= -27,-193,-186,-180, 8, 12, 23, -5, 2, 20, -12, -16, 26, 39, -16, -95, -41, 15,-184, 46; /M: SY='K'; M= -30, -23, 34, 17, -16, -18,-179, -8, 36, 9, -15, 9, -18, -4, 10, -19, 10, -46,-196, -76; /M: SY='M'; M= -22,-193, 32, 10, -25, -17, -29, -13, 10, -55, 65, -2, -1, 21, -4, 4, 1, -66, 33, 6; /M: SY='W'; M= -53,-196, -56, -14, -19, -60,-180, 12, 25, -20, 8, 8, -62, -8, 60, -19, -15, -12, 61, 13; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 220 in 206 different sequences |
| Number of true positive hits | 220 in 206 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 4 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 98.21 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 2 |
| Feature key [info] | DOMAIN |
| Feature description [info] | CHCH |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
206 sequences
CHC10_HUMAN (Q8WYQ3 ), CHCH1_HUMAN (Q96BP2 ), CHCH1_MOUSE (Q9CQA6 ), CHCH2_HUMAN (Q9Y6H1 ), CHCH2_MOUSE (Q9D1L0 ), CHCH3_CAEEL (Q21551 ), CHCH5_HUMAN (Q9BSY4 ), CHCH5_MOUSE (Q9CQP3 ), CHCH7_BOVIN (Q17Q91 ), CHCH7_HUMAN (Q9BUK0 ), CHCH7_MACFA (Q8SPI2 ), CHCH7_MOUSE (Q8K2Q5 ), CHCH7_XENLA (Q2TAP8 ), CHCH7_XENTR (Q28GG4 ), CHCH9_HUMAN (Q5T1J5 ), CMC4_BOVIN (Q0VBY0 ), CMC4_CANAW (C4YIM0 ), CMC4_CANTT (C5M6H7 ), CMC4_CLAL4 (C4Y2J3 ), CMC4_DEBHA (B5RTE0 ), CMC4_HUMAN (P56277 ), CMC4_LACTC (C5E268 ), CMC4_LODEL (A5DUN2 ), CMC4_MOUSE (Q61908 ), CMC4_SCHPO (G2TRJ8 ), CMC4_YARLI (Q6C4R1 ), CMC4_YEAS1 (B3LM82 ), CMC4_YEAS2 (C7GRF7 ), CMC4_YEAS7 (A6ZMQ6 ), CMC4_YEAS8 (C8ZF59 ), CMC4_YEAST (Q3E7A9 ), CMC4_ZYGRC (C5DT65 ), COA4_HUMAN (Q9NYJ1 ), COA4_MOUSE (Q8BT51 ), COA4_YEAST (Q05809 ), COA5_BOVIN (Q3ZCK8 ), COA5_DANRE (Q0P451 ), COA5_HUMAN (Q86WW8 ), COA5_MOUSE (Q99M07 ), COA5_PONAB (Q5RFJ0 ), COA5_XENLA (A1L3N6 ), COA5_XENTR (Q28CA1 ), COA6_BOVIN (Q2M2S5 ), COA6_HUMAN (Q5JTJ3 ), COA6_MOUSE (Q8BGD8 ), COA6_SCHPO (G2TRP6 ), COA6_YEAST (Q3E846 ), COX12_SCHPO (O94581 ), COX12_YEAST (Q01519 ), COX17_CANLF (Q6J3Q7 ), COX17_DICDI (Q54ID0 ), COX17_HUMAN (Q14061 ), COX17_MOUSE (P56394 ), COX17_PIG (P81045 ), COX17_SCHPO (Q9P7Z7 ), COX17_YEAST (Q12287 ), COX19_ASHGO (Q75AF9 ), COX19_BOVIN (A8E4L1 ), COX19_CANAL (Q5AL10 ), COX19_CANGA (Q6FVQ3 ), COX19_CRYNB (P0CM87 ), COX19_CRYNJ (P0CM86 ), COX19_DICDI (Q54IA0 ), COX19_HUMAN (Q49B96 ), COX19_KLULA (Q6CS47 ), COX19_MAGOY (P0CT19 ), COX19_MOUSE (Q8K0C8 ), COX19_PARBR (Q462Q7 ), COX19_SCHPO (O14056 ), COX19_USTMA (Q4P821 ), COX19_YEAST (Q3E731 ), COX23_ASHGO (Q75D94 ), COX23_ASPCL (A1CH57 ), COX23_CANAL (Q5A884 ), COX23_CANGA (Q6FQX5 ), COX23_COCIM (Q1DJH5 ), COX23_CRYNB (P0CM71 ), COX23_CRYNJ (P0CM70 ), COX23_DEBHA (Q6BKN1 ), COX23_EMENI (Q5B4S6 ), COX23_GIBZE (Q4IAJ1 ), COX23_KLULA (Q6CIT9 ), COX23_NEUCR (Q7S4H6 ), COX23_PARBR (Q208S3 ), COX23_PHANO (Q0UWF1 ), COX23_YARLI (Q6CF49 ), COX23_YEAST (P38824 ), COX6B_DICDI (Q54P95 ), COXM1_BOVIN (Q3SZM6 ), COXM1_HUMAN (Q7Z7K0 ), COXM1_MOUSE (Q9CPZ8 ), COXM1_SCHPO (O74347 ), COXM1_YEAS1 (B3LQW4 ), COXM1_YEAS7 (A6ZZI5 ), COXM1_YEAST (P36064 ), COXM2_BOVIN (Q2NKR3 ), COXM2_CAEEL (Q8MNU7 ), COXM2_DANRE (Q6DHJ6 ), COXM2_HUMAN (Q9NRP2 ), COXM2_MOUSE (Q8K199 ), COXM2_SCHPO (G2TRU5 ), COXM2_TAEGU (B5FXK1 ), COXM2_XENTR (Q28BU7 ), COXM2_YEAST (Q3E7A4 ), CX171_ARATH (Q9LJQ9 ), CX172_ARATH (Q94FT1 ), CX6B1_ARATH (Q9S7L9 ), CX6B1_BOVIN (P00429 ), CX6B1_HUMAN (P14854 ), CX6B1_MACFA (Q4R374 ), CX6B1_MACMU (Q53CG4 ), CX6B1_MOUSE (P56391 ), CX6B1_PONAB (Q5RCT0 ), CX6B1_TARSY (Q7YRK6 ), CX6B2_ARATH (Q945L0 ), CX6B2_BOVIN (Q6YFP9 ), CX6B2_HUMAN (Q6YFQ2 ), CX6B2_MOUSE (Q80ZN9 ), CX6B2_RAT (Q6YFQ1 ), CX6B3_ARATH (Q9SUD3 ), CX6BL_ARATH (Q9LPJ2 ), HAR1_CAEEL (Q09254 ), MC25A_DANRE (Q63ZW2 ), MC25A_XENLA (Q6AX41 ), MC25B_XENLA (Q5U509 ), MDM35_YEAST (O60200 ), MI40A_XENLA (Q6NU12 ), MI40B_XENLA (Q63ZK1 ), MIA40_ASHGO (Q757A5 ), MIA40_ASPFU (Q4WGL2 ), MIA40_ASPOR (Q2USJ2 ), MIA40_BOVIN (Q2KHZ4 ), MIA40_CANAL (O94030 ), MIA40_CANGA (Q6FW26 ), MIA40_CRYNB (P0CM69 ), MIA40_CRYNJ (P0CM68 ), MIA40_DANRE (Q6DEI8 ), MIA40_DEBHA (Q6BSK8 ), MIA40_EMENI (P0C1D2 ), MIA40_GIBZE (Q4IK03 ), MIA40_HUMAN (Q8N4Q1 ), MIA40_KLULA (Q6CSA1 ), MIA40_MOUSE (Q8VEA4 ), MIA40_NEUCR (Q7S3S2 ), MIA40_RAT (Q5BJN5 ), MIA40_SCHPO (P87059 ), MIA40_USTMA (Q4P8D2 ), MIA40_XENTR (Q6PBC3 ), MIA40_YEAST (P36046 ), MIC19_BOVIN (Q5E9D3 ), MIC19_HUMAN (Q9NX63 ), MIC19_MOUSE (Q9CRB9 ), MIC25_BOVIN (Q32L35 ), MIC25_HUMAN (Q9BRQ6 ), MIC25_MOUSE (Q91VN4 ), MIC25_RAT (D4A7N1 ), MIC25_XENTR (Q5FVV3 ), MIS35_CAEEL (P45967 ), MIX14_YEAST (Q04341 ), MRP10_ASHGO (Q756Q5 ), MRP10_SCHPO (O13973 ), MRP10_YEAST (O75012 ), NDA8A_ARATH (Q9SQT4 ), NDA8B_ARATH (Q8LGE7 ), NDS5A_ARATH (O82238 ), NDS5B_ARATH (Q9LZI6 ), NDUA8_BOVIN (P42029 ), NDUA8_DICDI (Q54P46 ), NDUA8_GORGO (Q0MQB0 ), NDUA8_HUMAN (P51970 ), NDUA8_MOUSE (Q9DCJ5 ), NDUA8_NEUCR (P21976 ), NDUA8_PANTR (Q0MQB1 ), NDUA8_PONAB (P0CB91 ), NDUA8_PONPY (P0CB92 ), NDUB7_ARATH (Q9SKC9 ), NDUB7_BOVIN (Q02368 ), NDUB7_CAEEL (P90789 ), NDUB7_DICDI (Q54V61 ), NDUB7_GORGO (Q0MQE3 ), NDUB7_HUMAN (P17568 ), NDUB7_MOUSE (Q9CR61 ), NDUB7_PANTR (Q0MQE4 ), NDUB7_PONPY (Q0MQE2 ), NDUF8_HUMAN (A1L188 ), NDUF8_MOUSE (A2AMZ4 ), NDUS5_BOVIN (Q02379 ), NDUS5_GORGO (Q0MQH3 ), NDUS5_HUMAN (O43920 ), NDUS5_MACFA (Q4R3M6 ), NDUS5_MOUSE (Q99LY9 ), NDUS5_PANTR (Q0MQH4 ), NDUS5_PONAB (P0CB87 ), NDUS5_PONPY (P0CB88 ), PT191_SCHPO (O42921 ), PT191_YEAST (Q02772 ), TRIA1_HUMAN (O43715 ), TRIA1_MOUSE (Q9D8Z2 ), TRIA1_XENTR (A9ULB4 ), TRIAA_XENLA (Q6INR6 ), TRIAB_XENLA (Q6DD38 ), Y4331_ARATH (Q9SMZ9 ), Y5933_DICDI (Q552P9 ), YBAI_SCHPO (Q96VG1 ), YJV1_SCHPO (O59799 ), YLZ2_CAEEL (P34415 )» more
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| UniProtKB/Swiss-Prot False negative sequences |
4 sequences
COX12_NEUCR (Q1K8U2 ), MIA40_ARATH (Q8GYJ4 ), MIA40_ORYSJ (Q7XKI7 ), MIX17_YEAST (Q03667 )» more |
| PDB [Detailed view] |
108 PDB
1EI0; 1HP8; 1OCC; 1OCO; 1OCR; 1OCZ; 1U96; 1U97; 1V54; 1V55; 1Z2G; 2DYR; 2DYS; 2EIJ; 2EIK; 2EIL; 2EIM; 2EIN; 2HP8; 2K3J; 2L0Y; 2LGQ; 2LQL; 2LQT; 2OCC; 2RN9; 2RNB; 2Y69; 2YBB; 2ZXT; 2ZXW; 3A3C; 3ABK; 3ABL; 3ABM; 3AG1; 3AG2; 3AG3; 3AG4; 3ASN; 3ASO; 3J9M; 3WG7; 3X2Q; 4XHR; 4XIZ; 4XZS; 4XZV; 4YTV; 4YTW; 4YTX; 5B1A; 5B1B; 5B3S; 5GPN; 5IY5; 5JQL; 5JQM; 5LC5; 5LDW; 5LDX; 5LUF; 5MRC; 5MRE; 5MRF; 5O31; 5W97; 5WAU; 5X19; 5X1B; 5X1F; 5XDQ; 5XDX; 5XTC; 5XTD; 5XTH; 5XTI; 5Z62; 5Z84; 5Z85; 5Z86; 5ZCO; 5ZCP; 5ZCQ; 6G2J; 6G72; 6GIQ; 6HU9; 6I3V; 6I3Y; 6I4Y; 6J8M; 6JUW; 6JY3; 6JY4; 6KYL; 6NKN; 6NL3; 6NMF; 6NMP; 6NU2; 6NU3; 6PCE; 6PCF; 6RW4; 6RW5; 6T0B; 6T15 » more |
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