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PROSITE entry PS51808


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General information about the entry

Entry name [info] CHCH
Accession [info] PS51808
Entry type [info] MATRIX
Date [info] 01-AUG-2016 CREATED;
01-AUG-2016 DATA UPDATE;
08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC51808
Associated ProRule [info] PRU01150

Name and characterization of the entry

Description [info] Coiled coil-helix-coiled coil-helix (CHCH) domain profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=43;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=43;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5089412; R2=0.0082775; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=966; N_SCORE=10.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=483; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-49; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...
 
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='H';  M=  -2,  19,  -4, -19,  -4,  14,  40, -72,   5, -56,   7, -30,-105,  26,  35,   2,  35, -54,  -1,  10;
/M: SY='D';  M=   4,  19,  33,  -6,-195,  30, -13, -55,  24,-192, -18,  18,  26,  32,  16,  13, -26,-106,-198,-186;
/M: SY='P';  M=   1,-196,   3,  35,-188, -31,  28,-185, -23, -80, -68,   3,  76,  20,  21, -38, -47,  -3,-192,  22;
/M: SY='C';  M=-178, 162,-198,-198,-189,-194,-198,-195,-194,-186,-186,-184,-209,-202,-201,-181,-178,-183,-218,-199;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='W';  M=  29,-190,   6, -31,  -8,  14,   5, -76,   5,   0,  29,  -7,   0,  26, -87,   1, -16, -33,  61,   0;
/M: SY='E';  M= -10,-194,  31,  60, -17, -50,  38, -63,  27,-101, -25, -28,  14,  39, -32, -20, -38, -11,-193,  -1;
/M: SY='E';  M= -15,-192,-169,  74,  19, -78,   7, -85, -82,  18, -37, -10,  31,  23, -46,  -9, -16, -44,-189,  -3;
/M: SY='M';  M=   0, -26,-183, -37,  53, -25,  -3,  21,  15, -14,  55,  33,-191,   9,   6, -47, -83, -35,  19,   8;
/M: SY='K';  M=  -9,  31,  25,  16, -69,-186, -25,  -7,  60, -15,  11, -11,-185,  19,  21, -12,  -7, -34,-196,-181;
/M: SY='A';  M=  54,-189,  23,  44, -51,-179,-176, -37,  10, -30, -20,   6, -59,  48,  -6,   8,-115, -81,-195,-183;
/M: SY='Y';  M=  -2,-191,-193,-188,  70,-192, -25,  15,-184,  21, -16,-188,  11, -43, -15,   5,-178, -84,  26,  79;
/M: SY='M';  M= -56,-192,  22,  -8,  27, -25,  38,  -6, -18,  32,  56, -23,-190,  43, -48, -47, -27, -25,  47, -55;
/M: SY='Q';  M= -33,-193,  30,  44,-192, -39, -81,-191,  53, -21,-181,   0,-182,  54,  30,   3,  -1,-187,-195, -41;
/M: SY='C';  M=-178, 162,-198,-198,-189,-194,-198,-195,-194,-186,-186,-184,-209,-202,-201,-181,-178,-183,-218,-199;
/M: SY='M';  M=  -6, -38,-191, -87,  31,-193,  43,  16,  -9,  41,  49,-184,-193,  -1,  11, -28, -83, -13,  46,  23;
/M: SY='W';  M= -12,-192,  17,  -8, -73,-185,  25, -65,  59, -44, -18,  -5,-185,  34,  27,  -3,   7,  -3,  64, -42;
/I:         I=-18; MD=-45;
/M: SY='E';  M=   3,-195,  32,  61, -47, -35, -26,-192,  -8, -45, -71,  20,-185,  24,  10,   3, -28,-113,-192,  35; D=-18;
/I:         I=-18; MD=-45;
/M: SY='N';  M= -65, -49, -24,  -2, -24, -21,  48, -40,  24,-188,  -1,  87, -48,-169, -49,  21,   4, -67,  29,  -2; D=-18;
/I:         I=-18; MD=-45;
/M: SY='Q';  M= -41,-195, -24,  19,  -4,  45,-177,-193,   2, -85, -63,  36,  26,  50, -21, -28,  18,-190,-191,   8; D=-18;
/I:         I=-18; MD=-45;
/M: SY='Y';  M=  -1,-195,  26,  38, -15,  -1,  30,  -2, -63, -71, -16,  17, -19,  26, -42,   5, -79, -65,-187,  55; D=-18;
/I:         I=-18; MD=-45;
/M: SY='D';  M= -44,-196,  61,  39, -23, -34,-176, -64,  -4, -14,   7,  26,  29,  22, -26,  -2, -49, -91,  22,-183; D=-18;
/I:         I=-18; MD=-45;
/M: SY='W';  M= -31,-196,  -2,  14,  10, -28,-182, -37,  28, -30, -40,  10,  28, -55,  43, -28, -18,   6,  46,-179; D=-18;
/I:         I=-18; MD=-45;
/M: SY='W';  M=  11,-198,   5,  -1,  15,   9, -28, -15,  16, -22, -25, -40, -18, -49, -42,  15, -38, -39,  26, -64; D=-18;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='K';  M=   1,-192,  27,  25, -66,-185,  33,-181,  48,  12,  -3,  21,   5,  19,  11, -50, -51, -45,-194, -10;
/M: SY='C';  M=-178, 162,-198,-198,-189,-194,-198,-195,-194,-186,-186,-184,-209,-202,-201,-181,-178,-183,-218,-199;
/M: SY='R';  M=   2,-190, -10,  26, -52, -44,   7, -16,  24,   4, -36,  19,-185,   3,  42,  18,  17, -42,-196,-180;
/M: SY='E';  M=   1,-193,  45,  48,-188,   0,  13, -33,  45, -51,-182,   3, -20, -21, -14, -26, -32, -57,   4,   9;
/M: SY='E';  M= -54, -79,-177,  60,  42,-106,   1, -47,   5,  44, -17,-112,-189,  31,-176,-181,-180, -33,  34,  37;
/M: SY='F';  M=   1,-191, -14, -60,  54,   2, -26,  24,   2, -65,  40,  11,-189,  34,  15,   2,-175, -17,  19, -27;
/M: SY='K';  M= -31,-194,  40,  39,-189, -72,   7,-118,  50, -88,  24, -40,-183,  32,  41, -17,  -2, -31,   2,  -4;
/M: SY='A';  M=  53, -35,  35,  32, -97, -70, -63, -43,   6,  -9,-176, -50,-184,  13,  -9,  10, -22,   0,-196, -40;
/M: SY='Y';  M=-185,-191,-197,-193,  71,-198,  11, -39,-189,  30,  58,-192,-199,-187,-187,-188,-180,  24,  32,  89;
/M: SY='K';  M= -50,-193,  -7,   0,   0, -96, -27, -38,  52,   5,  17,  27,-188,  29,  47, -96, -11, -58,   3,  15;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='Q';  M= -47,-194,  27,  51,-190, -51,  -2, -33,  46, -10, -83,  13,-183,  54,  16,  -7, -63, -69,-195, -38;
/M: SY='C';  M=-179, 161,-199,-199,-189,-194,-199,-196,-195,-187,-187,-185,-210,-202,-201,-182,-179,-184,-219,-200;
/M: SY='C';  M=   9,  41,-187, -25,  -4,-190,-185, -72,  34,  17,  25,-182,  27, -77,  24, -52,   7,  31,  31,-177;
/M: SY='R';  M= -22,-191, -89,  15, -51, -78,  15, -55,  32,  20,  34, -15,-187,  17,  40,  27,  -2, -51,-190,  10;
/M: SY='K';  M=   0,-193,  39,  36, -26, -20,  -4,-194,  48, -87, -81, -29,-183,  37,  22,  35, -67,-189,-194, -26;
/M: SY='W';  M=   6,-194,  -8,   2,  31,-188,  48, -29, -19, -25,  -3,  14,-191,   0, -15, -37, -34, -17, 104,  46;
/M: SY='Y';  M= -27,-193,-186,-180,   8,  12,  23,  -5,   2,  20, -12, -16,  26,  39, -16, -95, -41,  15,-184,  46;
/M: SY='K';  M= -30, -23,  34,  17, -16, -18,-179,  -8,  36,   9, -15,   9, -18,  -4,  10, -19,  10, -46,-196, -76;
/M: SY='M';  M= -22,-193,  32,  10, -25, -17, -29, -13,  10, -55,  65,  -2,  -1,  21,  -4,   4,   1, -66,  33,   6;
/M: SY='W';  M= -53,-196, -56, -14, -19, -60,-180,  12,  25, -20,   8,   8, -62,  -8,  60, -19, -15, -12,  61,  13;
/I:         E1=0; IE=-380; DE=-380;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.


Total number of hits 221 in 207 different sequences
Number of true positive hits 221 in 207 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 3
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 98.66 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] CHCH
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 207 sequences 

CHC10_HUMAN (Q8WYQ3), CHCH1_HUMAN (Q96BP2), CHCH1_MOUSE (Q9CQA6), 

CHCH2_HUMAN (Q9Y6H1), CHCH2_MOUSE (Q9D1L0), CHCH3_CAEEL (Q21551), 
CHCH5_HUMAN (Q9BSY4), CHCH5_MOUSE (Q9CQP3), CHCH7_BOVIN (Q17Q91), 
CHCH7_HUMAN (Q9BUK0), CHCH7_MACFA (Q8SPI2), CHCH7_MOUSE (Q8K2Q5), 
CHCH7_XENLA (Q2TAP8), CHCH7_XENTR (Q28GG4), CHCH9_HUMAN (Q5T1J5), 
CMC4_BOVIN  (Q0VBY0), CMC4_CANAW  (C4YIM0), CMC4_CANTT  (C5M6H7), 
CMC4_CLAL4  (C4Y2J3), CMC4_DEBHA  (B5RTE0), CMC4_HUMAN  (P56277), 
CMC4_LACTC  (C5E268), CMC4_LODEL  (A5DUN2), CMC4_MOUSE  (Q61908), 
CMC4_SCHPO  (G2TRJ8), CMC4_YARLI  (Q6C4R1), CMC4_YEAS1  (B3LM82), 
CMC4_YEAS2  (C7GRF7), CMC4_YEAS7  (A6ZMQ6), CMC4_YEAS8  (C8ZF59), 
CMC4_YEAST  (Q3E7A9), CMC4_ZYGRC  (C5DT65), COA4_HUMAN  (Q9NYJ1), 
COA4_MOUSE  (Q8BT51), COA4_YEAST  (Q05809), COA5_BOVIN  (Q3ZCK8), 
COA5_DANRE  (Q0P451), COA5_HUMAN  (Q86WW8), COA5_MOUSE  (Q99M07), 
COA5_PONAB  (Q5RFJ0), COA5_XENLA  (A1L3N6), COA5_XENTR  (Q28CA1), 
COA6_BOVIN  (Q2M2S5), COA6_HUMAN  (Q5JTJ3), COA6_MOUSE  (Q8BGD8), 
COA6_SCHPO  (G2TRP6), COA6_YEAST  (Q3E846), COX12_NEUCR (Q1K8U2), 
COX12_SCHPO (O94581), COX12_YEAST (Q01519), COX17_CANLF (Q6J3Q7), 
COX17_DICDI (Q54ID0), COX17_HUMAN (Q14061), COX17_MOUSE (P56394), 
COX17_PIG   (P81045), COX17_SCHPO (Q9P7Z7), COX17_YEAST (Q12287), 
COX19_BOVIN (A8E4L1), COX19_CANAL (Q5AL10), COX19_CANGA (Q6FVQ3), 
COX19_CRYNB (P0CM87), COX19_CRYNJ (P0CM86), COX19_DICDI (Q54IA0), 
COX19_EREGS (Q75AF9), COX19_HUMAN (Q49B96), COX19_KLULA (Q6CS47), 
COX19_MAGOY (P0CT19), COX19_MOUSE (Q8K0C8), COX19_PARBR (Q462Q7), 
COX19_SCHPO (O14056), COX19_USTMA (Q4P821), COX19_YEAST (Q3E731), 
COX23_ASPCL (A1CH57), COX23_CANAL (Q5A884), COX23_CANGA (Q6FQX5), 
COX23_COCIM (Q1DJH5), COX23_CRYNB (P0CM71), COX23_CRYNJ (P0CM70), 
COX23_DEBHA (Q6BKN1), COX23_EMENI (Q5B4S6), COX23_EREGS (Q75D94), 
COX23_GIBZE (Q4IAJ1), COX23_KLULA (Q6CIT9), COX23_NEUCR (Q7S4H6), 
COX23_PARBR (Q208S3), COX23_PHANO (Q0UWF1), COX23_YARLI (Q6CF49), 
COX23_YEAST (P38824), COX6B_DICDI (Q54P95), COXM1_BOVIN (Q3SZM6), 
COXM1_HUMAN (Q7Z7K0), COXM1_MOUSE (Q9CPZ8), COXM1_SCHPO (O74347), 
COXM1_YEAS1 (B3LQW4), COXM1_YEAS7 (A6ZZI5), COXM1_YEAST (P36064), 
COXM2_BOVIN (Q2NKR3), COXM2_CAEEL (Q8MNU7), COXM2_DANRE (Q6DHJ6), 
COXM2_HUMAN (Q9NRP2), COXM2_MOUSE (Q8K199), COXM2_SCHPO (G2TRU5), 
COXM2_TAEGU (B5FXK1), COXM2_XENTR (Q28BU7), COXM2_YEAST (Q3E7A4), 
CX171_ARATH (Q9LJQ9), CX172_ARATH (Q94FT1), CX6B1_ARATH (Q9S7L9), 
CX6B1_BOVIN (P00429), CX6B1_CARSF (Q7YRK6), CX6B1_HUMAN (P14854), 
CX6B1_MACFA (Q4R374), CX6B1_MACMU (Q53CG4), CX6B1_MOUSE (P56391), 
CX6B1_PONAB (Q5RCT0), CX6B2_ARATH (Q945L0), CX6B2_BOVIN (Q6YFP9), 
CX6B2_HUMAN (Q6YFQ2), CX6B2_MOUSE (Q80ZN9), CX6B2_RAT   (Q6YFQ1), 
CX6B3_ARATH (Q9SUD3), CX6BL_ARATH (Q9LPJ2), HAR1_CAEEL  (Q09254), 
MC25A_DANRE (Q63ZW2), MC25A_XENLA (Q6AX41), MC25B_XENLA (Q5U509), 
MDM35_YEAST (O60200), MI40A_XENLA (Q6NU12), MI40B_XENLA (Q63ZK1), 
MIA40_ASPFU (Q4WGL2), MIA40_ASPOR (Q2USJ2), MIA40_BOVIN (Q2KHZ4), 
MIA40_CANAL (O94030), MIA40_CANGA (Q6FW26), MIA40_CRYNB (P0CM69), 
MIA40_CRYNJ (P0CM68), MIA40_DANRE (Q6DEI8), MIA40_DEBHA (Q6BSK8), 
MIA40_EMENI (P0C1D2), MIA40_EREGS (Q757A5), MIA40_GIBZE (Q4IK03), 
MIA40_HUMAN (Q8N4Q1), MIA40_KLULA (Q6CSA1), MIA40_MOUSE (Q8VEA4), 
MIA40_NEUCR (Q7S3S2), MIA40_RAT   (Q5BJN5), MIA40_SCHPO (P87059), 
MIA40_USTMA (Q4P8D2), MIA40_XENTR (Q6PBC3), MIA40_YEAST (P36046), 
MIC19_BOVIN (Q5E9D3), MIC19_HUMAN (Q9NX63), MIC19_MOUSE (Q9CRB9), 
MIC25_BOVIN (Q32L35), MIC25_HUMAN (Q9BRQ6), MIC25_MOUSE (Q91VN4), 
MIC25_RAT   (D4A7N1), MIC25_XENTR (Q5FVV3), MIS35_CAEEL (P45967), 
MIX14_YEAST (Q04341), MRP10_EREGS (Q756Q5), MRP10_SCHPO (O13973), 
MRP10_YEAST (O75012), NDA8A_ARATH (Q9SQT4), NDA8B_ARATH (Q8LGE7), 
NDS5A_ARATH (O82238), NDS5B_ARATH (Q9LZI6), NDUA8_BOVIN (P42029), 
NDUA8_DICDI (Q54P46), NDUA8_GORGO (Q0MQB0), NDUA8_HUMAN (P51970), 
NDUA8_MOUSE (Q9DCJ5), NDUA8_NEUCR (P21976), NDUA8_PANTR (Q0MQB1), 
NDUA8_PONAB (P0CB91), NDUA8_PONPY (P0CB92), NDUB7_ARATH (Q9SKC9), 
NDUB7_BOVIN (Q02368), NDUB7_CAEEL (P90789), NDUB7_DICDI (Q54V61), 
NDUB7_GORGO (Q0MQE3), NDUB7_HUMAN (P17568), NDUB7_MOUSE (Q9CR61), 
NDUB7_PANTR (Q0MQE4), NDUB7_PONPY (Q0MQE2), NDUF8_HUMAN (A1L188), 
NDUF8_MOUSE (A2AMZ4), NDUS5_BOVIN (Q02379), NDUS5_GORGO (Q0MQH3), 
NDUS5_HUMAN (O43920), NDUS5_MACFA (Q4R3M6), NDUS5_MOUSE (Q99LY9), 
NDUS5_PANTR (Q0MQH4), NDUS5_PONAB (P0CB87), NDUS5_PONPY (P0CB88), 
PT191_SCHPO (O42921), PT191_YEAST (Q02772), TRIA1_HUMAN (O43715), 
TRIA1_MOUSE (Q9D8Z2), TRIA1_XENTR (A9ULB4), TRIAA_XENLA (Q6INR6), 
TRIAB_XENLA (Q6DD38), Y4331_ARATH (Q9SMZ9), Y5933_DICDI (Q552P9), 
YBAI_SCHPO  (Q96VG1), YJV1_SCHPO  (O59799), YLZ2_CAEEL  (P34415)
» more

UniProtKB/Swiss-Prot
False negative sequences		 3 sequences 

MIA40_ARATH (Q8GYJ4), MIA40_ORYSJ (Q7XKI7), MIX17_YEAST (Q03667)


				
	

	

		PDB
[Detailed view]		
		
			209 PDB
			


			1EI0; 1HP8; 1OCC; 1OCO; 1OCR; 1OCZ; 1U96; 1U97; 1V54; 1V55; 1Z2G; 2DYR; 
			
				2DYS; 2EIJ; 2EIK; 2EIL; 2EIM; 2EIN; 2HP8; 2K3J; 2L0Y; 2LGQ; 2LQL; 2LQT; 
				2OCC; 2RN9; 2RNB; 2Y69; 2YBB; 2ZXT; 2ZXW; 3A3C; 3ABK; 3ABL; 3ABM; 3AG1; 
				3AG2; 3AG3; 3AG4; 3ASN; 3ASO; 3J9M; 3WG7; 3X2Q; 4XHR; 4XIZ; 4XZS; 4XZV; 
				4YTV; 4YTW; 4YTX; 5B1A; 5B1B; 5B3S; 5GPN; 5IY5; 5JQL; 5JQM; 5LC5; 5LDW; 
				5LDX; 5LUF; 5MRC; 5MRE; 5MRF; 5O31; 5W97; 5WAU; 5X19; 5X1B; 5X1F; 5XDQ; 
				5XDX; 5XTC; 5XTD; 5XTH; 5XTI; 5Z62; 5Z84; 5Z85; 5Z86; 5ZCO; 5ZCP; 5ZCQ; 
				6G2J; 6G72; 6GIQ; 6HU9; 6I3V; 6I3Y; 6I4Y; 6J8M; 6JUW; 6JY3; 6JY4; 6KYL; 
				6NKN; 6NL3; 6NMF; 6NMP; 6NU2; 6NU3; 6PCE; 6PCF; 6RW4; 6RW5; 6T0B; 6T15; 
				6VLZ; 6VMI; 6YMX; 6YMY; 6ZM5; 6ZM6; 6ZR2; 6ZS9; 6ZSA; 6ZSB; 6ZSC; 6ZSD; 
				6ZSE; 6ZSG; 6ZTQ; 7A23; 7A24; 7A5F; 7A5G; 7A5I; 7A5K; 7AK5; 7AK6; 7AQQ; 
				7AQW; 7AR7; 7AR8; 7ARB; 7B93; 7COH; 7CP5; 7D5W; 7D5X; 7DGQ; 7DGR; 7DGS; 
				7DGZ; 7DH0; 7DKF; 7EV7; 7L08; 7O37; 7O3C; 7O3E; 7OG4; 7P2E; 7PNW; 7PO1; 
				7PO2; 7PO3; 7PSA; 7QI4; 7QI5; 7QI6; 7QSD; 7QSK; 7QSL; 7QSM; 7QSN; 7QSO; 
				7R41; 7R42; 7R43; 7R44; 7R45; 7R46; 7R47; 7R48; 7R4C; 7R4D; 7R4F; 7R4G; 
				7THU; 7TIE; 7TIH; 7TII; 7VUW; 7VVR; 7W3E; 7XMA; 7XMB; 7Y44; 7YPY; 8AG0; 
				8BEF; 8BEH; 8BPX; 8BQ5; 8BQ6; 8C8Q; 8D4T; 8D8K; 8D8L; 8E7S; 8EC0; 8GVM; 
				8H8R; 8H8S; 8IJN; 8OIR; 8OIS
			
			

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