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| annotation rule: PRU01161 |
General rule information
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| Accession | PRU01161 |
| Dates | 30-SEP-2016 (Created) 22-NOV-2019 (Last updated, Version 5) |
| Data class | Domain |
| Predictors | PROSITE; PS51635; PNPLA |
| Name | Patatin-like phospholipase (PNPLA) domain |
| Function | PNPLA domain containing proteins display lipase and transacylase properties and appear to have major roles in the regulation of lipid metabolism. The PNPLA domain has a Ser-Asp catalytic dyad. |
Propagated annotation
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Gene Ontology
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case <FTGroup:1>
GO:0016787; Molecular function: hydrolase activity.
GO:0016042; Biological process: lipid catabolic process.
GO:0016042; Biological process: lipid catabolic process.
Keywords
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end case
Features
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| From: PS51635 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | PNPLA # | |||||||||
| MOTIF | 5 | 10 | GXGXXG # | G-x-G-x-x-G | ||||||||
| MOTIF | 35 | 39 | GXSXG # | G-x-S-x-G | ||||||||
| MOTIF | 168 | 170 | DGA/G # | D-G-[AG] | ||||||||
| ACT_SITE | 37 | 37 | Nucleophile | S | 1 | |||||||
| ACT_SITE | 168 | 168 | Proton acceptor | D | 1 | |||||||
Additional information
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| Size range | 188-208 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q8LPW4 (PAT17_SOLCD) |
| Scope | Eukaryota
Bacteria
Viruses |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Bacteria [19] Eukaryota [144] Viruses [4] All [ 167 ]
- Retrieve set of proteins with 3D structure for this domain