General rule information
[?]
Accession |
PRU01161 |
Dates |
30-SEP-2016 (Created) 22-NOV-2019 (Last updated, Version 5) |
Name |
Patatin-like phospholipase (PNPLA) domain |
Function |
PNPLA domain containing proteins display lipase and transacylase properties and appear to have major roles in the regulation of lipid metabolism. The PNPLA domain has a Ser-Asp catalytic dyad. |
Propagated annotation
[?]
case <FTGroup:1>
GO:0016787; Molecular function: hydrolase activity.
GO:0016042; Biological process: lipid catabolic process.
end case
From: PS51635 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
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|
PNPLA #
|
|
|
|
|
|
|
MOTIF
|
|
5
|
|
10
|
|
GXGXXG #
|
|
|
|
G-x-G-x-x-G
|
|
|
MOTIF
|
|
35
|
|
39
|
|
GXSXG #
|
|
|
|
G-x-S-x-G
|
|
|
MOTIF
|
|
168
|
|
170
|
|
DGA/G #
|
|
|
|
D-G-[AG]
|
|
|
ACT_SITE
|
|
37
|
|
37
|
|
Nucleophile
|
|
|
|
S
|
|
1
|
ACT_SITE
|
|
168
|
|
168
|
|
Proton acceptor
|
|
|
|
D
|
|
1
|
Additional information
[?]
Size range |
188-208 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q8LPW4 (PAT17_SOLCD) |
Scope |
Eukaryota
Bacteria
Viruses |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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