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annotation rule: PRU01161

General rule information [?]

Accession PRU01161
Dates 30-SEP-2016 (Created)
22-NOV-2019 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51635; PNPLA
Name Patatin-like phospholipase (PNPLA) domain
Function PNPLA domain containing proteins display lipase and transacylase properties and appear to have major roles in the regulation of lipid metabolism. The PNPLA domain has a Ser-Asp catalytic dyad.

Propagated annotation [?]


Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function: hydrolase activity.
GO:0016042; Biological process: lipid catabolic process.

Keywords [?]

Hydrolase
Lipid degradation
Lipid metabolism
end case


Features [?]

From: PS51635
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       PNPLA #        
MOTIF     5     10       GXGXXG #     G-x-G-x-x-G  
MOTIF     35     39       GXSXG #     G-x-S-x-G  
MOTIF     168     170       DGA/G #     D-G-[AG]  
ACT_SITE     37     37       Nucleophile     S   1
ACT_SITE     168     168       Proton acceptor     D   1

Additional information [?]

Size range 188-208 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q8LPW4 (PAT17_SOLCD)
Scope
Eukaryota
Bacteria
Viruses
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]