ProRule PRU01161

General rule information [?]

Accession PRU01161
Dates 30-SEP-2016 (Created)
22-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51635; PNPLA
Name Patatin-like phospholipase (PNPLA) domain
Function PNPLA domain containing proteins display lipase and transacylase properties and appear to have major roles in the regulation of lipid metabolism. The PNPLA domain has a Ser-Asp catalytic dyad.
Scope(s) Eukaryota
Example(s) Q8LPW4 (PAT17_SOLCD);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function:hydrolase activity
GO:0016042; Biological process:lipid catabolic process

Features [?]

From: PS51635
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PNPLA #"
MOTIF 5 10 /note="GXGXXG #" G-x-G-x-x-G
MOTIF 35 39 /note="GXSXG #" G-x-S-x-G
MOTIF 168 170 /note="DGA/G #" D-G-[AG]
ACT_SITE 37 37 /note="Nucleophile" S 1
ACT_SITE 168 168 /note="Proton acceptor" D 1

Additional information [?]

Size range 188-208 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]