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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01161


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01161
General rule information [?]

Accession PRU01161
Dates 30-SEP-2016 (Created)
22-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51635; PNPLA
Name Patatin-like phospholipase (PNPLA) domain
Function PNPLA domain containing proteins display lipase and transacylase properties and appear to have major roles in the regulation of lipid metabolism. The PNPLA domain has a Ser-Asp catalytic dyad.
Scope(s) Eukaryota
Bacteria
Viruses
Example(s) Q8LPW4;

Propagated annotation [?]

Keywords [?]

Hydrolase
Lipid degradation
Lipid metabolism
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function:hydrolase activity
GO:0016042; Biological process:lipid catabolic process

Features [?]

From: PS51635
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PNPLA #"
MOTIF 5 10 /note="GXGXXG #" G-x-G-x-x-G
MOTIF 35 39 /note="GXSXG #" G-x-S-x-G
MOTIF 168 170 /note="DGA/G #" D-G-[AG]
ACT_SITE 37 37 /note="Nucleophile" S 1
ACT_SITE 168 168 /note="Proton acceptor" D 1

Additional information [?]

Size range 188-208 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]