ProRule PRU01182

General rule information [?]

Accession PRU01182
Dates 3-JUL-2017 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS50249; MPN
Name MPN (Mpr1, Pad1 N-terminal) domain
Function MPN+ domain-containing proteins are classified as metalloenzymes responsible for isopeptidase activity. These proteins contain a conserved glutamate (E) and a JAMM (Jab1/MPN/Mov34 metalloenzyme) motif, typically consisting of a canonical sequence (H-x-H-x[7]-S-x[2]-D) and coordinating a zinc ion. MPN- domains are recognizable by the absence of essential Zn(2+)- coordinating residues that are required for catalytic function. In protein complexes, an MPN+ domain can associate with MPN- domains for purposes that are not well understood.
Scope(s) Bacteria
Example(s) Q9KVC9 (Y217_VIBCH);

Propagated annotation [?]

Keywords [?]

Features [?]

From: PS50249
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MPN #"
MOTIF 77 90 /note="JAMM motif #" H-[NST]-H-x(7)-S-x(2)-D
BINDING 77 77 /ligand="Zn(2+)"
H 1
BINDING 79 79 /ligand="Zn(2+)"
H 1
BINDING 90 90 /ligand="Zn(2+)"
D 1

Additional information [?]

Size range 57-178 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]