ProRule PRU01182
General rule information
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Accession | PRU01182 |
Dates | 3-JUL-2017 (Created)
19-NOV-2022 (Last updated, Version 5) |
Data class | Domain; |
Predictors |
PROSITE; PS50249; MPN |
Name | MPN (Mpr1, Pad1 N-terminal) domain |
Function | MPN+ domain-containing proteins are classified as metalloenzymes responsible for isopeptidase activity. These proteins contain a conserved glutamate (E) and a JAMM (Jab1/MPN/Mov34 metalloenzyme) motif, typically consisting of a canonical sequence (H-x-H-x[7]-S-x[2]-D) and coordinating a zinc ion. MPN- domains are recognizable by the absence of essential Zn(2+)- coordinating residues that are required for catalytic function. In protein complexes, an MPN+ domain can associate with MPN- domains for purposes that are not well understood. |
Scope(s) |
Bacteria Eukaryota Archaea Euryarchaeota Viruses |
Example(s) | Q9KVC9 (Y217_VIBCH); |
Propagated annotation
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Keywords
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case <FTGroup:1> | |
Hydrolase | |
Metal-binding | |
Metalloprotease | |
Protease | |
Zinc | |
end case |
Features
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From: PS50249 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="MPN #" | |||||||||
MOTIF | 77 | 90 | /note="JAMM motif #" | H-[NST]-H-x(7)-S-x(2)-D | ||||||||
BINDING | 77 | 77 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
BINDING | 79 | 79 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
BINDING | 90 | 90 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
D | 1 |
Additional information
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Size range | 57-178 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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