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General rule information [?]

Accession PRU01182
Dates 3-JUL-2017 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS50249; MPN
Names MPN (Mpr1, Pad1 N-terminal) domain; Mov34 domain; JAB domain; PAD-1 domain; JAMM (JAB1/MPN/Mov34 metalloenzyme) domain
Function MPN+ domain-containing proteins are classified as metalloenzymes responsible for isopeptidase activity. These proteins contain a conserved glutamate (E) and a JAMM (Jab1/MPN/Mov34 metalloenzyme) motif, typically consisting of a canonical sequence (H-x-H-x[7]-S-x[2]-D) and coordinating a zinc ion. MPN- domains are recognizable by the absence of essential Zn(2+)- coordinating residues that are required for catalytic function. In protein complexes, an MPN+ domain can associate with MPN- domains for purposes that are not well understood.

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
end case

Features [?]

From: PS50249
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       MPN #        
MOTIF     77     90       JAMM motif #     H-[NST]-H-x(7)-S-x(2)-D  
BINDING     77     77       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     79     79       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     90     90       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     D   1

Additional information [?]

Size range 57-178 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9KVC9 (Y217_VIBCH)
Archaea; Euryarchaeota
Comments None


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UniProtKB rule member sequences [?]