PRU01182
General rule information
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| Accession | PRU01182 |
| Dates | 3-JUL-2017 (Created) 19-NOV-2022 (Last updated, Version 5) |
| Data class | Domain |
| Predictors | PROSITE; PS50249; MPN |
| Names | MPN (Mpr1, Pad1 N-terminal) domain; Mov34 domain; JAB domain; PAD-1 domain; JAMM (JAB1/MPN/Mov34 metalloenzyme) domain |
| Function | MPN+ domain-containing proteins are classified as metalloenzymes responsible for isopeptidase activity. These proteins contain a conserved glutamate (E) and a JAMM (Jab1/MPN/Mov34 metalloenzyme) motif, typically consisting of a canonical sequence (H-x-H-x[7]-S-x[2]-D) and coordinating a zinc ion. MPN- domains are recognizable by the absence of essential Zn(2+)- coordinating residues that are required for catalytic function. In protein complexes, an MPN+ domain can associate with MPN- domains for purposes that are not well understood. |
Propagated annotation
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Keywords
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case <FTGroup:1>
end case
Features
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| From: PS50249 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | MPN # | |||||||||
| MOTIF | 77 | 90 | JAMM motif # | H-[NST]-H-x(7)-S-x(2)-D | ||||||||
| BINDING | 77 | 77 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
| BINDING | 79 | 79 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
| BINDING | 90 | 90 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | D | 1 | |||||||
Additional information
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| Size range | 57-178 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q9KVC9 (Y217_VIBCH) |
| Scope | Bacteria
Eukaryota
Archaea; Euryarchaeota
Viruses |
| Comments | None |
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UniProtKB rule member sequences
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