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annotation rule: PRU01182

General rule information [?]

Accession PRU01182
Dates 3-JUL-2017 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS50249; MPN
Names MPN (Mpr1, Pad1 N-terminal) domain; Mov34 domain; JAB domain; PAD-1 domain; JAMM (JAB1/MPN/Mov34 metalloenzyme) domain
Function MPN+ domain-containing proteins are classified as metalloenzymes responsible for isopeptidase activity. These proteins contain a conserved glutamate (E) and a JAMM (Jab1/MPN/Mov34 metalloenzyme) motif, typically consisting of a canonical sequence (H-x-H-x[7]-S-x[2]-D) and coordinating a zinc ion. MPN- domains are recognizable by the absence of essential Zn(2+)- coordinating residues that are required for catalytic function. In protein complexes, an MPN+ domain can associate with MPN- domains for purposes that are not well understood.

Propagated annotation [?]


Keywords [?]

case <FTGroup:1>
Hydrolase
Metal-binding
Metalloprotease
Protease
Zinc
end case


Features [?]

From: PS50249
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       MPN #        
MOTIF     77     90       JAMM motif #     H-[NST]-H-x(7)-S-x(2)-D  
METAL     77     77       Zinc; catalytic     H   1
METAL     79     79       Zinc; catalytic     H   1
METAL     90     90       Zinc; catalytic     D   1

Additional information [?]

Size range 57-178 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9KVC9 (Y217_VIBCH)
Scope
Bacteria
Eukaryota
Archaea; Euryarchaeota
Viruses
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]