![]() |
|
annotation rule: PRU01182 |
Accession | PRU01182 |
Dates | 3-JUL-2017 (Created) 22-NOV-2019 (Last updated, Version 3) |
Data class | Domain |
Predictors | PROSITE; PS50249; MPN |
Names | MPN (Mpr1, Pad1 N-terminal) domain; Mov34 domain; JAB domain; PAD-1 domain; JAMM (JAB1/MPN/Mov34 metalloenzyme) domain |
Function | MPN+ domain-containing proteins are classified as metalloenzymes responsible for isopeptidase activity. These proteins contain a conserved glutamate (E) and a JAMM (Jab1/MPN/Mov34 metalloenzyme) motif, typically consisting of a canonical sequence (H-x-H-x[7]-S-x[2]-D) and coordinating a zinc ion. MPN- domains are recognizable by the absence of essential Zn(2+)- coordinating residues that are required for catalytic function. In protein complexes, an MPN+ domain can associate with MPN- domains for purposes that are not well understood. |
From: PS50249 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | MPN # | |||||||||
MOTIF | 77 | 90 | JAMM motif # | H-[NST]-H-x(7)-S-x(2)-D | ||||||||
METAL | 77 | 77 | Zinc; catalytic | H | 1 | |||||||
METAL | 79 | 79 | Zinc; catalytic | H | 1 | |||||||
METAL | 90 | 90 | Zinc; catalytic | D | 1 |
Size range | 57-178 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q9KVC9 (Y217_VIBCH) |
Scope | Bacteria
Eukaryota
Archaea; Euryarchaeota
Viruses |
Comments | None |