We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01182
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01182
General rule information
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| Accession | PRU01182 |
| Dates | 03-JUL-2017 (Created)
08-OCT-2024 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50249; MPN |
Name | MPN (Mpr1, Pad1 N-terminal) domain |
| Function | MPN+ domain-containing proteins are classified as metalloenzymes responsible for isopeptidase activity. These proteins contain a conserved glutamate (E) and a JAMM (Jab1/MPN/Mov34 metalloenzyme) motif, typically consisting of a canonical sequence (H-x-H-x[7]-S-x[2]-D) and coordinating a zinc ion. MPN- domains are recognizable by the absence of essential Zn(2+)- coordinating residues that are required for catalytic function. In protein complexes, an MPN+ domain can associate with MPN- domains for purposes that are not well understood. |
| Scope(s) |
Bacteria Eukaryota Archaea Methanobacteriati Viruses |
| Example(s) | Q9KVC9; |
Propagated annotation
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Keywords
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| case <FTGroup:1> | |
| Hydrolase | |
| Metal-binding | |
| Metalloprotease | |
| Protease | |
| Zinc | |
| end case | |
Features
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| From: PS50249 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="MPN #" | |||||||||
| MOTIF | 77 | 90 | /note="JAMM motif #" | H-[NST]-H-x(7)-S-x(2)-D | ||||||||
| BINDING | 77 | 77 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 79 | 79 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 90 | 90 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
D | 1 | |||||||
Additional information
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| Size range | 57-178 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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