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annotation rule: PRU01184

General rule information [?]

Accession PRU01184
Dates 20-JUL-2017 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51839; 4FE4S_HC3
Name His(Cys)3-ligated-type [4Fe-4S] domain
Function The His(Cys)3-ligated-type [4Fe-4S] domain consists of just two alpha helices separated by a loop region that coordinates a [4Fe-4S] cluster through an unusual H-x(3)-C-x(2)-C-x(5)-C motif that includes one His and three Cys residues.

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
Cofactor [4Fe-4S] cluster
end case

Cross-references [?]

PROSITE PS00642; COMPLEX1_75K_2; 0-1;

Gene Ontology [?]

case <FTGroup:1>
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0005506; Molecular function: iron ion binding.

Keywords [?]

end case

Features [?]

From: PS51839
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       4Fe-4S His(Cys)3-ligated-type #        
BINDING     17     17       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1     H   1
BINDING     19     19       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1     H   1
BINDING     21     21       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1     C   1
BINDING     24     24       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1     C   1
BINDING     30     30       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1     C   1

Additional information [?]

Size range 30-51 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P15690 (NDUS1_BOVIN)
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]