We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

ProRule PRU01184

View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01184

General rule information [?]

Accession	PRU01184
Dates	20-JUL-2017 (Created) 19-NOV-2022 (Last updated, Version 7)
Data class	Domain;
Predictors	PROSITE; PS51839; 4FE4S_HC3
Name	His(Cys)3-ligated-type [4Fe-4S] domain
Function	The His(Cys)3-ligated-type [4Fe-4S] domain consists of just two alpha helices separated by a loop region that coordinates a [4Fe-4S] cluster through an unusual H-x(3)-C-x(2)-C-x(5)-C motif that includes one His and three Cys residues.
Scope(s)	Bacteria Eukaryota
Example(s)	P15690;

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
COFACTOR	Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
end case

Keywords [?]

4Fe-4S
Iron
Iron-sulfur
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding
GO:0005506; Molecular function:iron ion binding

Cross-references [?]

PROSITE

PS00642; COMPLEX1_75K_2; 0-1;

Features [?]

From: PS51839

Key

From

Description

Tag

Condition

FTGroup

DOMAIN

from

/note="4Fe-4S His(Cys)3-ligated-type #"

BINDING