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|
| annotation rule: PRU01184 |
General rule information
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| Accession | PRU01184 |
| Dates | 20-JUL-2017 (Created) 19-NOV-2022 (Last updated, Version 6) |
| Data class | Domain |
| Predictors | PROSITE; PS51839; 4FE4S_HC3 |
| Name | His(Cys)3-ligated-type [4Fe-4S] domain |
| Function | The His(Cys)3-ligated-type [4Fe-4S] domain consists of just two alpha helices separated by a loop region that coordinates a [4Fe-4S] cluster through an unusual H-x(3)-C-x(2)-C-x(5)-C motif that includes one His and three Cys residues. |
Propagated annotation
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Comments
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case <FTGroup:1>
| Cofactor | [4Fe-4S] cluster |
end case
Cross-references
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| PROSITE | PS00642; COMPLEX1_75K_2; 0-1; |
Gene Ontology
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case <FTGroup:1>
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0005506; Molecular function: iron ion binding.
GO:0005506; Molecular function: iron ion binding.
Keywords
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end case
Features
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| From: PS51839 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | 4Fe-4S His(Cys)3-ligated-type # | |||||||||
| BINDING | 17 | 17 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1 | H | 1 | |||||||
| BINDING | 19 | 19 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1 | H | 1 | |||||||
| BINDING | 21 | 21 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1 | C | 1 | |||||||
| BINDING | 24 | 24 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1 | C | 1 | |||||||
| BINDING | 30 | 30 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1 | C | 1 | |||||||
Additional information
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| Size range | 30-51 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P15690 (NDUS1_BOVIN) |
| Scope | Bacteria
Eukaryota |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Bacteria [46] Eukaryota [17] All [ 63 ]
- Retrieve set of proteins with 3D structure for this domain