PROSITE logo

ProRule PRU01184


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01184
Accession PRU01184
Dates 20-JUL-2017 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51839; 4FE4S_HC3
Name His(Cys)3-ligated-type [4Fe-4S] domain
Function The His(Cys)3-ligated-type [4Fe-4S] domain consists of just two alpha helices separated by a loop region that coordinates a [4Fe-4S] cluster through an unusual H-x(3)-C-x(2)-C-x(5)-C motif that includes one His and three Cys residues.
Scope(s) Bacteria
Eukaryota
Example(s) P15690 (NDUS1_BOVIN);

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
end case

Keywords [?]

4Fe-4S
Iron
Iron-sulfur
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding
GO:0005506; Molecular function:iron ion binding

Cross-references [?]

PROSITE PS00642; COMPLEX1_75K_2; 0-1;

Features [?]

From: PS51839
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="4Fe-4S His(Cys)3-ligated-type #"
BINDING 17 17 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="#1"		 H 1
BINDING 19 19 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="#1"		 H 1
BINDING 21 21 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="#1"		 C 1
BINDING 24 24 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="#1"		 C 1
BINDING 30 30 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="#1"		 C 1

Additional information [?]

Size range 30-51 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



View rule in raw text format (no links)

UniProtKB rule member sequences [?]