ProRule PRU01184
General rule information
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Accession | PRU01184 |
Dates | 20-JUL-2017 (Created)
19-NOV-2022 (Last updated, Version 6) |
Data class | Domain; |
Predictors |
PROSITE; PS51839; 4FE4S_HC3 |
Name | His(Cys)3-ligated-type [4Fe-4S] domain |
Function | The His(Cys)3-ligated-type [4Fe-4S] domain consists of just two alpha helices separated by a loop region that coordinates a [4Fe-4S] cluster through an unusual H-x(3)-C-x(2)-C-x(5)-C motif that includes one His and three Cys residues. |
Scope(s) |
Bacteria Eukaryota |
Example(s) | P15690 (NDUS1_BOVIN); |
Propagated annotation
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Comments
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case <FTGroup:1> | |
COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; |
end case |
Keywords
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4Fe-4S | |
Iron | |
Iron-sulfur | |
Metal-binding | |
end case |
Gene Ontology
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case <FTGroup:1> | |
GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding | |
GO:0005506; Molecular function:iron ion binding |
Cross-references
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PROSITE | PS00642; COMPLEX1_75K_2; 0-1; |
Features
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From: PS51839 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="4Fe-4S His(Cys)3-ligated-type #" | |||||||||
BINDING | 17 | 17 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1" |
H | 1 | |||||||
BINDING | 19 | 19 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1" |
H | 1 | |||||||
BINDING | 21 | 21 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1" |
C | 1 | |||||||
BINDING | 24 | 24 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1" |
C | 1 | |||||||
BINDING | 30 | 30 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="#1" |
C | 1 |
Additional information
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Size range | 30-51 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [47] Eukaryota [18] All [ 65 ]
- Retrieve set of proteins with 3D structure for this domain