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annotation rule: PRU01197

General rule information [?]

Accession PRU01197
Dates 2-JAN-2018 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51850; KARI_N
Name KARI N-terminal domain
Function Ketol-acid reductoisomerase (KARI; EC 1.1.1.86), also known as acetohydroxy acid isomeroreductase (AHIR or AHAIR), catalyzes the conversion of acetohydroxy acids into dihydroxy valerates in the second step of the biosynthetic pathway for the essential branched-chain amino acids valine, leucine, and isoleucine. KARIs are composed of two types of domains, an N- terminal Rossmann fold domain and one or two C-terminal knotted domains.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the ketol-acid reductoisomerase family.

Gene Ontology [?]

GO:0004455; Molecular function: ketol-acid reductoisomerase activity.
GO:0009097; Biological process: isoleucine biosynthetic process.
GO:0009099; Biological process: valine biosynthetic process.
case <FTGroup:1>
GO:0050661; Molecular function: NADP binding.

Keywords [?]

NADP
end case

Amino-acid biosynthesis
Branched-chain amino acid biosynthesis
Oxidoreductase

Features [?]

From: PS51850
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       KARI N-terminal Rossmann #        
NP_BIND     27     30       NADP         1
ACT_SITE     110     110             H  
BINDING     50     50       NADP     R   1
BINDING     55     55       NADP     S   1
BINDING     136     136       NADP; via amide nitrogen     G   1

Additional information [?]

Size range 135-205 amino acids
Related rules None
Repeats 1
Topology Undefined
Example A7GMU0 (ILVC_BACCN)
Scope
Bacteria
Archaea
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]