ProRule PRU01197

General rule information [?]

Accession PRU01197
Dates 2-JAN-2018 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51850; KARI_N
Name KARI N-terminal domain
Function Ketol-acid reductoisomerase (KARI; EC, also known as acetohydroxy acid isomeroreductase (AHIR or AHAIR), catalyzes the conversion of acetohydroxy acids into dihydroxy valerates in the second step of the biosynthetic pathway for the essential branched-chain amino acids valine, leucine, and isoleucine. KARIs are composed of two types of domains, an N- terminal Rossmann fold domain and one or two C-terminal knotted domains.
Scope(s) Bacteria
Example(s) A7GMU0 (ILVC_BACCN);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the ketol-acid reductoisomerase family.

Keywords [?]

Gene Ontology [?]

GO:0004455; Molecular function:ketol-acid reductoisomerase activity
GO:0009097; Biological process:isoleucine biosynthetic process
GO:0009099; Biological process:valine biosynthetic process
case <FTGroup:1>
GO:0050661; Molecular function:NADP binding

Features [?]

From: PS51850
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="KARI N-terminal Rossmann #"
BINDING 27 30 /ligand="NADP(+)"
ACT_SITE 110 110 H
BINDING 50 50 /ligand="NADP(+)"
R 1
BINDING 55 55 /ligand="NADP(+)"
S 1
BINDING 136 136 /ligand="NADP(+)"
G 1

Additional information [?]

Size range 135-205 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]