General rule information
[?]
Accession |
PRU01197 |
Dates |
2-JAN-2018 (Created) 22-NOV-2019 (Last updated, Version 3) |
Predictors |
PROSITE; PS51850; KARI_N
|
Name |
KARI N-terminal domain |
Function |
Ketol-acid reductoisomerase (KARI; EC 1.1.1.86), also known as acetohydroxy acid isomeroreductase (AHIR or AHAIR), catalyzes the conversion of acetohydroxy acids into dihydroxy valerates in the second step of the biosynthetic pathway for the essential branched-chain amino acids valine, leucine, and isoleucine. KARIs are composed of two types of domains, an N- terminal Rossmann fold domain and one or two C-terminal knotted domains. |
Propagated annotation
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Similarity |
Belongs to the ketol-acid reductoisomerase family. |
GO:0004455; Molecular function: ketol-acid reductoisomerase activity.
GO:0009097; Biological process: isoleucine biosynthetic process.
GO:0009099; Biological process: valine biosynthetic process.
case <FTGroup:1>
end case
From: PS51850 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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DOMAIN
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from
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to
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KARI N-terminal Rossmann #
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NP_BIND
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27
|
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30
|
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NADP
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|
|
|
|
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1
|
ACT_SITE
|
|
110
|
|
110
|
|
|
|
|
|
H
|
|
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BINDING
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|
50
|
|
50
|
|
NADP
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|
|
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R
|
|
1
|
BINDING
|
|
55
|
|
55
|
|
NADP
|
|
|
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S
|
|
1
|
BINDING
|
|
136
|
|
136
|
|
NADP; via amide nitrogen
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|
|
|
G
|
|
1
|
Additional information
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Size range |
135-205 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
A7GMU0 (ILVC_BACCN) |
Scope |
Bacteria
Archaea
Eukaryota |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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