ProRule PRU01198

Accession	PRU01198
Dates	3-JAN-2018 (Created) 19-NOV-2022 (Last updated, Version 4)
Data class	Domain;
Predictors	PROSITE; PS51851; KARI_C
Name	KARI C-terminal domain
Function	Ketol-acid reductoisomerase (KARI; EC 1.1.1.86), also known as acetohydroxy acid isomeroreductase (AHIR or AHAIR), catalyzes the conversion of acetohydroxy acids into dihydroxy valerates in the second step of the biosynthetic pathway for the essential branched-chain amino acids valine, leucine, and isoleucine. KARIs are composed of two types of domains, an N- terminal Rossmann fold domain and one or two C-terminal knotted domains.
Scope(s)	Bacteria Archaea Eukaryota
Example(s)	A7GMU0 (ILVC_BACCN);

From: PS51851
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="KARI C-terminal knotted #"
BINDING	9	9	/ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1"		D	1
BINDING	9	9	/ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2"		D	1
BINDING	13	13	/ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1"		E	1
BINDING	45	45	/ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2"		E	2
BINDING	49	49	/ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2"		E	2
case <FTGroup:2>
BINDING	70	70	/ligand="substrate"		S
end case