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annotation rule: PRU01198

General rule information [?]

Accession PRU01198
Dates 3-JAN-2018 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51851; KARI_C
Name KARI C-terminal domain
Function Ketol-acid reductoisomerase (KARI; EC, also known as acetohydroxy acid isomeroreductase (AHIR or AHAIR), catalyzes the conversion of acetohydroxy acids into dihydroxy valerates in the second step of the biosynthetic pathway for the essential branched-chain amino acids valine, leucine, and isoleucine. KARIs are composed of two types of domains, an N- terminal Rossmann fold domain and one or two C-terminal knotted domains.

Propagated annotation [?]

Comments [?]

Similarity Belongs to the ketol-acid reductoisomerase family.

Gene Ontology [?]

GO:0004455; Molecular function: ketol-acid reductoisomerase activity.
GO:0009097; Biological process: isoleucine biosynthetic process.
GO:0009099; Biological process: valine biosynthetic process.
case <FTGroup:1> or <FTGroup:2>
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case

Features [?]

From: PS51851
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       KARI C-terminal knotted #        
METAL     9     9       Magnesium 1     D   1
METAL     9     9       Magnesium 2     D   1
METAL     13     13       Magnesium 1     E   1
METAL     45     45       Magnesium 2     E   2
METAL     49     49       Magnesium 2     E   2
case <FTGroup:2>
BINDING     70     70       Substrate     S  
end case

Additional information [?]

Size range 125-155 amino acids
Related rules None
Repeats 1
Topology Undefined
Comments None


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UniProtKB rule member sequences [?]