ProRule PRU01198

General rule information [?]

Accession PRU01198
Dates 3-JAN-2018 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51851; KARI_C
Name KARI C-terminal domain
Function Ketol-acid reductoisomerase (KARI; EC, also known as acetohydroxy acid isomeroreductase (AHIR or AHAIR), catalyzes the conversion of acetohydroxy acids into dihydroxy valerates in the second step of the biosynthetic pathway for the essential branched-chain amino acids valine, leucine, and isoleucine. KARIs are composed of two types of domains, an N- terminal Rossmann fold domain and one or two C-terminal knotted domains.
Scope(s) Bacteria
Example(s) A7GMU0 (ILVC_BACCN);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the ketol-acid reductoisomerase family.

Keywords [?]

Gene Ontology [?]

GO:0004455; Molecular function:ketol-acid reductoisomerase activity
GO:0009097; Biological process:isoleucine biosynthetic process
GO:0009099; Biological process:valine biosynthetic process
case <FTGroup:1> or <FTGroup:2>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51851
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="KARI C-terminal knotted #"
BINDING 9 9 /ligand="Mg(2+)"
D 1
BINDING 9 9 /ligand="Mg(2+)"
D 1
BINDING 13 13 /ligand="Mg(2+)"
E 1
BINDING 45 45 /ligand="Mg(2+)"
E 2
BINDING 49 49 /ligand="Mg(2+)"
E 2
case <FTGroup:2>
BINDING 70 70 /ligand="substrate" S
end case

Additional information [?]

Size range 125-155 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]