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| annotation rule: PRU01210 |
General rule information
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| Accession | PRU01210 |
| Dates | 15-MAY-2018 (Created) 22-NOV-2019 (Last updated, Version 2) |
| Data class | Domain |
| Predictors | PROSITE; PS51863; LCN_CSAB |
| Name | LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain |
| Function | Most long-chain neurotoxins (LCNs) are composed of 60-70 residues and are cross-linked by four disulphide bridges. The long chain or voltage- gated sodium channels scorpion neurotoxins (NaScTxs) can be classified either as alpha-toxins, which slow down Na(+) channel inactivation, or beta-toxins, which affect the channel activation process. |
Propagated annotation
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Comments
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| Subcellular location | Secreted. |
| Tissue specificity | Expressed by the venom gland. |
Gene Ontology
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GO:0090729; Molecular function: toxin activity.
GO:0005576; Cellular component: extracellular region.
GO:0008200; Molecular function: ion channel inhibitor activity.
GO:0005576; Cellular component: extracellular region.
GO:0008200; Molecular function: ion channel inhibitor activity.
Keywords
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case <FTTag:disulf>
end case
Features
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| From: PS51863 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | LCN-type CS-alpha/beta # | |||||||||
| DISULFID | 11 | 62 | disulf | C-x*-C | ||||||||
| DISULFID | 15 | 37 | disulf | C-x*-C | ||||||||
| DISULFID | 23 | 43 | disulf | C-x*-C | ||||||||
| DISULFID | 27 | 45 | disulf | C-x*-C | ||||||||
| DISULFID | 38 | 62 | disulf | C-x*-C | ||||||||
| DISULFID | 56 | 62 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 50-75 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P54135 (SCX8_MESMA) |
| Scope | Eukaryota; Scorpiones |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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