General rule information
[?]
Accession |
PRU01210 |
Dates |
15-MAY-2018 (Created) 22-NOV-2019 (Last updated, Version 2) |
Predictors |
PROSITE; PS51863; LCN_CSAB
|
Name |
LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain |
Function |
Most long-chain neurotoxins (LCNs) are composed of 60-70 residues and are cross-linked by four disulphide bridges. The long chain or voltage- gated sodium channels scorpion neurotoxins (NaScTxs) can be classified either as alpha-toxins, which slow down Na(+) channel inactivation, or beta-toxins, which affect the channel activation process. |
Propagated annotation
[?]
Subcellular location |
Secreted. |
Tissue specificity |
Expressed by the venom gland. |
GO:0090729; Molecular function: toxin activity.
GO:0005576; Cellular component: extracellular region.
GO:0008200; Molecular function: ion channel inhibitor activity.
case <FTTag:disulf>
end case
From: PS51863 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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DOMAIN
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from
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to
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LCN-type CS-alpha/beta #
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DISULFID
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11
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62
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disulf
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C-x*-C
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DISULFID
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15
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37
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disulf
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C-x*-C
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DISULFID
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23
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43
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disulf
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C-x*-C
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DISULFID
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27
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45
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disulf
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C-x*-C
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DISULFID
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38
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62
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disulf
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C-x*-C
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DISULFID
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56
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62
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disulf
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C-x*-C
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Additional information
[?]
Size range |
50-75 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P54135 (SCX8_MESMA) |
Scope |
Eukaryota; Scorpiones |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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