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annotation rule: PRU01210

General rule information [?]

Accession PRU01210
Dates 15-MAY-2018 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51863; LCN_CSAB
Name LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain
Function Most long-chain neurotoxins (LCNs) are composed of 60-70 residues and are cross-linked by four disulphide bridges. The long chain or voltage- gated sodium channels scorpion neurotoxins (NaScTxs) can be classified either as alpha-toxins, which slow down Na(+) channel inactivation, or beta-toxins, which affect the channel activation process.

Propagated annotation [?]


Comments [?]

Subcellular location Secreted.
Tissue specificity Expressed by the venom gland.

Gene Ontology [?]

GO:0090729; Molecular function: toxin activity.
GO:0005576; Cellular component: extracellular region.
GO:0008200; Molecular function: ion channel inhibitor activity.

Keywords [?]

Secreted
Toxin
Neurotoxin
case <FTTag:disulf>
Disulfide bond
end case

Ion channel impairing toxin
Voltage-gated sodium channel impairing toxin

Features [?]

From: PS51863
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       LCN-type CS-alpha/beta #        
DISULFID     11     62           disulf   C-x*-C  
DISULFID     15     37           disulf   C-x*-C  
DISULFID     23     43           disulf   C-x*-C  
DISULFID     27     45           disulf   C-x*-C  
DISULFID     38     62           disulf   C-x*-C  
DISULFID     56     62           disulf   C-x*-C  

Additional information [?]

Size range 50-75 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P54135 (SCX8_MESMA)
Scope
Eukaryota; Scorpiones
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]