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ProRule PRU01210


General rule information [?]

Accession PRU01210
Dates 15-MAY-2018 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51863; LCN_CSAB
Name LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain
Function Most long-chain neurotoxins (LCNs) are composed of 60-70 residues and are cross-linked by four disulphide bridges. The long chain or voltage- gated sodium channels scorpion neurotoxins (NaScTxs) can be classified either as alpha-toxins, which slow down Na(+) channel inactivation, or beta-toxins, which affect the channel activation process.
Scope(s) Eukaryota
Scorpiones
Example(s) P54135 (SCX8_MESMA);

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONSecreted.
TISSUE SPECIFICITYExpressed by the venom gland.

Keywords [?]

Secreted
Toxin
Neurotoxin
case <FTTag:disulf>
Disulfide bond
end case
Ion channel impairing toxin
Voltage-gated sodium channel impairing toxin

Gene Ontology [?]

GO:0090729; Molecular function:toxin activity
GO:0005576; Cellular component:extracellular region
GO:0008200; Molecular function:ion channel inhibitor activity

Features [?]

From: PS51863
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="LCN-type CS-alpha/beta #"
DISULFID 11 62 disulf C-x*-C
DISULFID 15 37 disulf C-x*-C
DISULFID 23 43 disulf C-x*-C
DISULFID 27 45 disulf C-x*-C
DISULFID 38 62 disulf C-x*-C
DISULFID 56 62 disulf C-x*-C

Additional information [?]

Size range 50-75 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]