ProRule PRU01210
General rule information
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Accession | PRU01210 |
Dates | 15-MAY-2018 (Created)
22-NOV-2019 (Last updated, Version 2) |
Data class | Domain; |
Predictors |
PROSITE; PS51863; LCN_CSAB |
Name | LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain |
Function | Most long-chain neurotoxins (LCNs) are composed of 60-70 residues and are cross-linked by four disulphide bridges. The long chain or voltage- gated sodium channels scorpion neurotoxins (NaScTxs) can be classified either as alpha-toxins, which slow down Na(+) channel inactivation, or beta-toxins, which affect the channel activation process. |
Scope(s) |
Eukaryota Scorpiones |
Example(s) | P54135 (SCX8_MESMA); |
Propagated annotation
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Comments
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SUBCELLULAR LOCATION | Secreted. |
TISSUE SPECIFICITY | Expressed by the venom gland. |
Keywords
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Secreted | |
Toxin | |
Neurotoxin | |
case <FTTag:disulf> | |
Disulfide bond | |
end case | |
Ion channel impairing toxin | |
Voltage-gated sodium channel impairing toxin |
Gene Ontology
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GO:0090729; Molecular function:toxin activity |
GO:0005576; Cellular component:extracellular region |
GO:0008200; Molecular function:ion channel inhibitor activity |
Features
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From: PS51863 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="LCN-type CS-alpha/beta #" | |||||||||
DISULFID | 11 | 62 | disulf | C-x*-C | ||||||||
DISULFID | 15 | 37 | disulf | C-x*-C | ||||||||
DISULFID | 23 | 43 | disulf | C-x*-C | ||||||||
DISULFID | 27 | 45 | disulf | C-x*-C | ||||||||
DISULFID | 38 | 62 | disulf | C-x*-C | ||||||||
DISULFID | 56 | 62 | disulf | C-x*-C |
Additional information
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Size range | 50-75 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [461] All [ 461 ]
- Retrieve set of proteins with 3D structure for this domain