We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01210
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01210
General rule information
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| Accession | PRU01210 |
| Dates | 15-MAY-2018 (Created)
22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51863; LCN_CSAB |
Name | LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain |
| Function | Most long-chain neurotoxins (LCNs) are composed of 60-70 residues and are cross-linked by four disulphide bridges. The long chain or voltage- gated sodium channels scorpion neurotoxins (NaScTxs) can be classified either as alpha-toxins, which slow down Na(+) channel inactivation, or beta-toxins, which affect the channel activation process. |
| Scope(s) |
Eukaryota Scorpiones |
| Example(s) | P54135; |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Secreted. |
| TISSUE SPECIFICITY | Expressed by the venom gland. |
Keywords
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| Secreted | |
| Toxin | |
| Neurotoxin | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
| Ion channel impairing toxin | |
| Voltage-gated sodium channel impairing toxin | |
Gene Ontology
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| GO:0090729; Molecular function:toxin activity |
| GO:0005576; Cellular component:extracellular region |
| GO:0008200; Molecular function:ion channel inhibitor activity |
Features
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| From: PS51863 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="LCN-type CS-alpha/beta #" | |||||||||
| DISULFID | 11 | 62 | disulf | C-x*-C | ||||||||
| DISULFID | 15 | 37 | disulf | C-x*-C | ||||||||
| DISULFID | 23 | 43 | disulf | C-x*-C | ||||||||
| DISULFID | 27 | 45 | disulf | C-x*-C | ||||||||
| DISULFID | 38 | 62 | disulf | C-x*-C | ||||||||
| DISULFID | 56 | 62 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 50-75 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [470] All [ 470 ]
- Retrieve set of proteins with 3D structure for this domain