We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01219
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01219
General rule information
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| Accession | PRU01219 |
| Dates | 13-AUG-2018 (Created)
22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51871; PV_P1_PRO |
Name | Potyviridae P1 protease domain |
| Function | The potyviral P1 protease domain bears the catalytic triad formed by histidine, aspartic and serine that is characteristic of the serine protease family. |
| Scope(s) |
Viruses Potyviridae |
| Example(s) | P0CJ95; |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | Contains: RecName: Full=P1 proteinase; EC=3.4.-.-; |
Keywords
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| Hydrolase | |
| Protease | |
| Serine protease | |
| end case | |
Gene Ontology
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| GO:0004252; Molecular function:serine-type endopeptidase activity |
Features
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| From: PS51871 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase S30 #" | |||||||||
| ACT_SITE | 54 | 54 | /note="For P1 proteinase activity" | H | 1 | |||||||
| ACT_SITE | 63 | 63 | /note="For P1 proteinase activity" | [DE] | 1 | |||||||
| ACT_SITE | 97 | 97 | /note="For P1 proteinase activity" | S | 1 | |||||||
| case <Feature:PS51871:146=[FY]> and <FTGroup:1> | ||||||||||||
| SITE | to | to+1 | /note="Cleavage; by P1 proteinase" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 130-160 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [56] All [ 56 ]
- Retrieve set of proteins with 3D structure for this domain