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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01220


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01220
General rule information [?]

Accession PRU01220
Dates 24-AUG-2018 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51872; ZF_ZBR
Name Zinc finger ZBR-type
Function The ZBR-type zinc finger is an autonomously folded domain with a central, twisted, four-stranded beta-sheet and two zinc ions on opposite ends of the sheet.
Scope(s) Eukaryota
Euteleostomi
Example(s) Q66H04;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

case (<Feature:PS51872:5=[CH]> and <Feature:PS51872:8=[CH]> and <Feature:PS51872:23=[CH]> and <Feature:PS51872:28=[CH]>) or (<Feature:PS51872:33=[CH]> and <Feature:PS51872:36=[CH]> and <Feature:PS51872:41=[CH]> and <Feature:PS51872:46=[CH]>)
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51872
Key From To Description Tag Condition FTGroup
case (<Feature:PS51872:5=[C]> and <Feature:PS51872:8=[C]> and <Feature:PS51872:23=[C]> and <Feature:PS51872:28=[C]>) and (<Feature:PS51872:33=[C]> and <Feature:PS51872:36=[C]> and <Feature:PS51872:41=[H]> and <Feature:PS51872:46=[C]>)
ZN_FING from to /note="ZBR-type #"
else case (<Feature:PS51872:5=[CH]> and <Feature:PS51872:8=[CH]> and <Feature:PS51872:23=[CH]> and <Feature:PS51872:28=[CH]>) and (<Feature:PS51872:33=[CH]> and <Feature:PS51872:36=[CH]> and <Feature:PS51872:41=[CH]> and <Feature:PS51872:46=[CH]>)
ZN_FING from to /note="ZBR-type #; atypical"
else
ZN_FING from to /note="ZBR-type #; degenerate"
end case
BINDING 5 5 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 8 8 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 28 28 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 33 33 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 36 36 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 41 41 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 46 46 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2

Additional information [?]

Size range 45-55 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]