PRU01221
General rule information
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Accession | PRU01221 |
Dates | 27-SEP-2018 (Created) 19-NOV-2022 (Last updated, Version 4) |
Data class | Domain |
Predictors | PROSITE; PS51873; TRIAD |
Name | TRIAD supradomain |
Function | The cysteine and histidine rich TRIAD domain architecture is highly conserved and found only in eukaryotes. The three fingers that define the TRIAD supradomain always appear in the same order RING1-IBR-RING2. All characterized proteins containing the TRIAD supradomain have been found to possess E3 ligase activity. |
Propagated annotation
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Cross-references
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Gene Ontology
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case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
GO:0046872; Molecular function: metal ion binding.
end case
case <Feature:PS51873:178=C>
GO:0000209; Biological process: protein polyubiquitination.
GO:0061630; Molecular function: ubiquitin protein ligase activity.
GO:0032436; Biological process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process.
GO:0031624; Molecular function: ubiquitin conjugating enzyme binding.
GO:0000151; Cellular component: ubiquitin ligase complex.
GO:0061630; Molecular function: ubiquitin protein ligase activity.
GO:0032436; Biological process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process.
GO:0031624; Molecular function: ubiquitin conjugating enzyme binding.
GO:0000151; Cellular component: ubiquitin ligase complex.
end case
Keywords
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case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
end case
case <Feature:PS51873:178=C>
end case
Features
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From: PS51873 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ZN_FING | 5 | 56 | RING-type # | |||||||||
ZN_FING | 75 | 138 | IBR-type | |||||||||
ZN_FING | 165 | 194 | RING-type #; atypical | |||||||||
REGION | from | to | TRIAD supradomain | |||||||||
ACT_SITE | 178 | 178 | C | |||||||||
BINDING | 5 | 5 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 | C | 1 | |||||||
BINDING | 8 | 8 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 | C | 1 | |||||||
BINDING | 23 | 23 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 | C | 2 | |||||||
BINDING | 25 | 25 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 | H | 2 | |||||||
BINDING | 28 | 28 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 | C | 1 | |||||||
BINDING | 31 | 31 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 | C | 1 | |||||||
BINDING | 51 | 51 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 | C | 2 | |||||||
BINDING | 56 | 56 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 | C | 2 | |||||||
BINDING | 95 | 95 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3 | C | 3 | |||||||
BINDING | 100 | 100 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3 | C | 3 | |||||||
BINDING | 117 | 117 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3 | C | 3 | |||||||
BINDING | 120 | 120 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3 | C | 3 | |||||||
BINDING | 125 | 125 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4 | C | 4 | |||||||
BINDING | 128 | 128 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4 | C | 4 | |||||||
BINDING | 133 | 133 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4 | H | 4 | |||||||
BINDING | 138 | 138 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4 | C | 4 | |||||||
BINDING | 165 | 165 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5 | C | 5 | |||||||
BINDING | 168 | 168 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5 | C | 5 | |||||||
BINDING | 183 | 183 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5 | C | 5 | |||||||
BINDING | 186 | 186 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5 | C | 5 |
case <Feature:PS51873:202-209=C-x*-H>
else
end case
Additional information
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Size range | 190-285 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q924T7 (RNF31_MOUSE) |
Scope | Eukaryota
Viruses; Mimivirus |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [78] Viruses [1] All [ 79 ]
- Retrieve set of proteins with 3D structure for this domain