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ProRule PRU01221

General rule information [?]

Accession	PRU01221
Dates	27-SEP-2018 (Created) 19-NOV-2022 (Last updated, Version 4)
Data class	Domain;
Predictors	PROSITE; PS51873; TRIAD
Name	TRIAD supradomain
Function	The cysteine and histidine rich TRIAD domain architecture is highly conserved and found only in eukaryotes. The three fingers that define the TRIAD supradomain always appear in the same order RING1-IBR-RING2. All characterized proteins containing the TRIAD supradomain have been found to possess E3 ligase activity.
Scope(s)	Eukaryota Viruses Mimivirus
Example(s)	Q924T7 (RNF31_MOUSE);

Propagated annotation [?]

Keywords [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
Metal-binding
Zinc
end case
Zinc-finger
case <Feature:PS51873:178=C>
Transferase
Ubl conjugation pathway
end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
GO:0046872; Molecular function:metal ion binding
end case
case <Feature:PS51873:178=C>
GO:0000209; Biological process:protein polyubiquitination
GO:0061630; Molecular function:ubiquitin protein ligase activity
GO:0032436; Biological process:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031624; Molecular function:ubiquitin conjugating enzyme binding
GO:0000151; Cellular component:ubiquitin ligase complex
end case

Cross-references [?]

PROSITE	PS00518; ZF_RING_1; 1;
PROSITE	PS50089; ZF_RING_2; 1;

Features [?]

From: PS51873
Key	From	To	Description	Tag	Condition	FTGroup
ZN_FING	5	56	/note="RING-type #"
ZN_FING	75	138	/note="IBR-type"
ZN_FING	165	194	/note="RING-type #; atypical"
REGION	from	to	/note="TRIAD supradomain"
ACT_SITE	178	178			C
BINDING	5	5	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	8	8	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	23	23	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	25	25	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		H	2
BINDING	28	28	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	31	31	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	51	51	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	56	56	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	95	95	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		C	3
BINDING	100	100	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		C	3
BINDING	117	117	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		C	3
BINDING	120	120	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		C	3
BINDING	125	125	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4"		C	4
BINDING	128	128	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4"		C	4
BINDING	133	133	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4"		H	4
BINDING	138	138	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4"		C	4
BINDING	165	165	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5"		C	5
BINDING	168	168	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5"		C	5
BINDING	183	183	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5"		C	5
BINDING	186	186	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5"		C	5
case <Feature:PS51873:202-209=C-x*-H>
BINDING	191	191	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6"		C	6
BINDING	194	194	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6"		C	6
BINDING	202	202	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6"		C	6
BINDING	209	209	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6"		H	6
else
BINDING	191	191	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6"		C	7
BINDING	194	194	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6"		C	7
BINDING	202	202	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6"		H	7
BINDING	209	209	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6"		C	7
end case

Additional information [?]

Size range	190-285 amino acids
Related rules	None
Fusion	None
Repeats	1
Topology	Undefined

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota	[79]
Viruses	[1]
All	[ 80 ]

Retrieve set of proteins with 3D structure for this domain