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annotation rule: PRU01221

General rule information [?]

Accession PRU01221
Dates 27-SEP-2018 (Created)
27-SEP-2018 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51873; TRIAD
Name TRIAD supradomain
Function The cysteine and histidine rich TRIAD domain architecture is highly conserved and found only in eukaryotes. The three fingers that define the TRIAD supradomain always appear in the same order RING1-IBR-RING2. All characterized proteins containing the TRIAD supradomain have been found to possess E3 ligase activity.

Propagated annotation [?]


Cross-references [?]

PROSITE PS00518; ZF_RING_1; 1;
PS50089; ZF_RING_2; 1;

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
GO:0046872; Molecular function: metal ion binding.
end case

case <Feature:PS51873:178=C>
GO:0000209; Biological process: protein polyubiquitination.
GO:0061630; Molecular function: ubiquitin protein ligase activity.
GO:0032436; Biological process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process.
GO:0031624; Molecular function: ubiquitin conjugating enzyme binding.
GO:0000151; Cellular component: ubiquitin ligase complex.
end case


Keywords [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
end case

case <Feature:PS51873:178=C>
end case


Features [?]

From: PS51873
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     5     56       RING-type #        
ZN_FING     75     138       IBR-type        
ZN_FING     165     194       RING-type #; atypical        
REGION     from     to       TRIAD supradomain        
ACT_SITE     178     178             C  
METAL     5     5       Zinc #1     C   1
METAL     8     8       Zinc #1     C   1
METAL     23     23       Zinc #2     C   2
METAL     25     25       Zinc #2; via pros nitrogen     H   2
METAL     28     28       Zinc #1     C   1
METAL     31     31       Zinc #1     C   1
METAL     51     51       Zinc #2     C   2
METAL     56     56       Zinc #2     C   2
METAL     95     95       Zinc #3     C   3
METAL     100     100       Zinc #3     C   3
METAL     117     117       Zinc #3     C   3
METAL     120     120       Zinc #3     C   3
METAL     125     125       Zinc #4     C   4
METAL     128     128       Zinc #4     C   4
METAL     133     133       Zinc #4; via tele nitrogen     H   4
METAL     138     138       Zinc #4     C   4
METAL     165     165       Zinc #5     C   5
METAL     168     168       Zinc #5     C   5
METAL     183     183       Zinc #5     C   5
METAL     186     186       Zinc #5     C   5
case <Feature:PS51873:202-209=C-x*-H>
METAL     191     191       Zinc #6     C   6
METAL     194     194       Zinc #6     C   6
METAL     202     202       Zinc #6     C   6
METAL     209     209       Zinc #6; via tele nitrogen     H   6
else
METAL     191     191       Zinc #6     C   7
METAL     194     194       Zinc #6     C   7
METAL     202     202       Zinc #6; via tele nitrogen     H   7
METAL     209     209       Zinc #6     C   7
end case


Additional information [?]

Size range 190-285 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q924T7 (RNF31_MOUSE)
Scope
Eukaryota
Viruses; Mimivirus
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]