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PRU01221


General rule information [?]

Accession PRU01221
Dates 27-SEP-2018 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51873; TRIAD
Name TRIAD supradomain
Function The cysteine and histidine rich TRIAD domain architecture is highly conserved and found only in eukaryotes. The three fingers that define the TRIAD supradomain always appear in the same order RING1-IBR-RING2. All characterized proteins containing the TRIAD supradomain have been found to possess E3 ligase activity.

Propagated annotation [?]


Cross-references [?]

PROSITE PS00518; ZF_RING_1; 1;
PS50089; ZF_RING_2; 1;

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
GO:0046872; Molecular function: metal ion binding.
end case

case <Feature:PS51873:178=C>
GO:0000209; Biological process: protein polyubiquitination.
GO:0061630; Molecular function: ubiquitin protein ligase activity.
GO:0032436; Biological process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process.
GO:0031624; Molecular function: ubiquitin conjugating enzyme binding.
GO:0000151; Cellular component: ubiquitin ligase complex.
end case


Keywords [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
Metal-binding
Zinc
end case

Zinc-finger
case <Feature:PS51873:178=C>
Transferase
Ubl conjugation pathway
end case


Features [?]

From: PS51873
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     5     56       RING-type #        
ZN_FING     75     138       IBR-type        
ZN_FING     165     194       RING-type #; atypical        
REGION     from     to       TRIAD supradomain        
ACT_SITE     178     178             C  
BINDING     5     5       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     C   1
BINDING     8     8       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     C   1
BINDING     23     23       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2     C   2
BINDING     25     25       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2     H   2
BINDING     28     28       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     C   1
BINDING     31     31       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     C   1
BINDING     51     51       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2     C   2
BINDING     56     56       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2     C   2
BINDING     95     95       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3     C   3
BINDING     100     100       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3     C   3
BINDING     117     117       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3     C   3
BINDING     120     120       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3     C   3
BINDING     125     125       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4     C   4
BINDING     128     128       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4     C   4
BINDING     133     133       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4     H   4
BINDING     138     138       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#4     C   4
BINDING     165     165       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5     C   5
BINDING     168     168       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5     C   5
BINDING     183     183       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5     C   5
BINDING     186     186       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#5     C   5
case <Feature:PS51873:202-209=C-x*-H>
BINDING     191     191       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6     C   6
BINDING     194     194       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6     C   6
BINDING     202     202       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6     C   6
BINDING     209     209       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6     H   6
else
BINDING     191     191       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6     C   7
BINDING     194     194       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6     C   7
BINDING     202     202       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6     H   7
BINDING     209     209       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#6     C   7
end case


Additional information [?]

Size range 190-285 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q924T7 (RNF31_MOUSE)
Scope
Eukaryota
Viruses; Mimivirus
Comments None

Copyright

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UniProtKB rule member sequences [?]