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ProRule PRU01223


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01223
Accession PRU01223
Dates 12-OCT-2018 (Created)
22-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51875; HAV_P48_PRO
Name Hypovirulence-associated virus (HAV) papain-like protease p48 domain
Function The HAV papain-like protease p48 is a cysteine protease, which forms the peptidase family C8. A Cys and a His catalytic residue are essential for autocatalytic cleavage between the cleavage site residues Gly and Ala located at the C-terminus of the domain.
Scope(s) Viruses
Hypovirus
Example(s) Q9YTU2 (POLB_CHPVU);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + Contains:
RecName: Full=Papain-like protease p48;
                 EC=3.4.22.-;

Comments [?]

FUNCTIONPapain-like protease p48 is a cysteine protease of the peptidase family C8.

Keywords [?]

Hydrolase
Protease
Thiol protease
end case

Gene Ontology [?]

GO:0008234; Molecular function:cysteine-type peptidase activity

Features [?]

From: PS51875
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C8 #"
ACT_SITE 71 71 /note="For papain-like protease p48 activity" C 1
ACT_SITE 118 118 /note="For papain-like protease p48 activity" H 1
SITE to to+1 /note="Cleavage; by papain-like protease p48" G-A

Additional information [?]

Size range 130-140 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]