ProRule PRU01223
General rule information
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| Accession | PRU01223 |
| Dates | 12-OCT-2018 (Created)
22-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51875; HAV_P48_PRO |
Name | Hypovirulence-associated virus (HAV) papain-like protease p48 domain |
| Function | The HAV papain-like protease p48 is a cysteine protease, which forms the peptidase family C8. A Cys and a His catalytic residue are essential for autocatalytic cleavage between the cleavage site residues Gly and Ala located at the C-terminus of the domain. |
| Scope(s) |
Viruses Hypovirus |
| Example(s) | Q9YTU2 (POLB_CHPVU); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + Contains: RecName: Full=Papain-like protease p48; EC=3.4.22.-; |
Comments
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| FUNCTION | Papain-like protease p48 is a cysteine protease of the peptidase family C8. |
Keywords
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| Hydrolase | |
| Protease | |
| Thiol protease | |
| end case | |
Gene Ontology
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| GO:0008234; Molecular function:cysteine-type peptidase activity |
Features
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| From: PS51875 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C8 #" | |||||||||
| ACT_SITE | 71 | 71 | /note="For papain-like protease p48 activity" | C | 1 | |||||||
| ACT_SITE | 118 | 118 | /note="For papain-like protease p48 activity" | H | 1 | |||||||
| SITE | to | to+1 | /note="Cleavage; by papain-like protease p48" | G-A | ||||||||
Additional information
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| Size range | 130-140 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [2] All [ 2 ]
- Retrieve set of proteins with 3D structure for this domain