We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01223
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01223
General rule information
[?]
| Accession | PRU01223 |
| Dates | 12-OCT-2018 (Created)
22-NOV-2019 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51875; HAV_P48_PRO |
Name | Hypovirulence-associated virus (HAV) papain-like protease p48 domain |
| Function | The HAV papain-like protease p48 is a cysteine protease, which forms the peptidase family C8. A Cys and a His catalytic residue are essential for autocatalytic cleavage between the cleavage site residues Gly and Ala located at the C-terminus of the domain. |
| Scope(s) |
Viruses Hypovirus |
| Example(s) | Q9YTU2; |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| case <FTGroup:1> | |
| Protein name | + Contains: RecName: Full=Papain-like protease p48; EC=3.4.22.-; |
Comments
[?]
| FUNCTION | Papain-like protease p48 is a cysteine protease of the peptidase family C8. |
Keywords
[?]
| Hydrolase | |
| Protease | |
| Thiol protease | |
| end case | |
Gene Ontology
[?]
| GO:0008234; Molecular function:cysteine-type peptidase activity |
Features
[?]
| From: PS51875 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C8 #" | |||||||||
| ACT_SITE | 71 | 71 | /note="For papain-like protease p48 activity" | C | 1 | |||||||
| ACT_SITE | 118 | 118 | /note="For papain-like protease p48 activity" | H | 1 | |||||||
| SITE | to | to+1 | /note="Cleavage; by papain-like protease p48" | G-A | ||||||||
Additional information
[?]
| Size range | 130-140 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Viruses [2] All [ 2 ]
- Retrieve set of proteins with 3D structure for this domain