We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01224
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01224
General rule information
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| Accession | PRU01224 |
| Dates | 19-OCT-2018 (Created)
22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51876; PV_NPRO |
Name | Pestivirus N-terminal protease (Npro) domain |
| Function | The pestivirus N-terminal protease Npro is a cysteine autoprotease that cleaves between its own C-terminus and the N-terminus of the core protein. Following the first cleavage reaction, Npro does not possess any proteolytic trans-activity but acts as a viral immediate effector to modulate the host cell's antiviral defenses. |
| Scope(s) |
Viruses Pestivirus |
| Example(s) | P19711; |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + Contains: RecName: Full=N-terminal protease; Short=N-pro; EC=3.4.22.-; AltName: Full=Autoprotease p20; |
Keywords
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| Hydrolase | |
| Protease | |
| Thiol protease | |
| end case | |
| Inhibition of host IRF3 by virus | |
| Inhibition of host RLR pathway by virus | |
| Inhibition of host innate immune response by virus | |
Gene Ontology
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| GO:0019082; Biological process:viral protein processing |
| GO:0004197; Molecular function:cysteine-type endopeptidase activity |
Features
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| From: PS51876 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C53 #" | |||||||||
| ACT_SITE | 49 | 49 | /note="For N-terminal protease activity" | H | 1 | |||||||
| ACT_SITE | 69 | 69 | /note="For N-terminal protease activity" | C | 1 | |||||||
| case <FTGroup:1> | ||||||||||||
| SITE | to | to+1 | /note="Cleavage; by autolysis" | C-{P} | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 165-175 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [5] All [ 5 ]
- Retrieve set of proteins with 3D structure for this domain