PRU01224
General rule information
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| Accession | PRU01224 |
| Dates | 19-OCT-2018 (Created) 22-NOV-2019 (Last updated, Version 2) |
| Data class | Domain |
| Predictors | PROSITE; PS51876; PV_NPRO |
| Names | Pestivirus N-terminal protease (Npro) domain; Peptidase C53 domain |
| Function | The pestivirus N-terminal protease Npro is a cysteine autoprotease that cleaves between its own C-terminus and the N-terminus of the core protein. Following the first cleavage reaction, Npro does not possess any proteolytic trans-activity but acts as a viral immediate effector to modulate the host cell's antiviral defenses. |
Propagated annotation
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Description
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case <FTGroup:1>
| + Contains: RecName: Full=N-terminal protease; Short=N-pro; EC 3.4.22.-; AltName: Full=Autoprotease p20; |
Gene Ontology
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GO:0019082; Biological process: viral protein processing.
GO:0004197; Molecular function: cysteine-type endopeptidase activity.
GO:0004197; Molecular function: cysteine-type endopeptidase activity.
Keywords
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end case
Inhibition of host IRF3 by virus
Inhibition of host RLR pathway by virus
Inhibition of host innate immune response by virus
Inhibition of host RLR pathway by virus
Inhibition of host innate immune response by virus
Features
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| From: PS51876 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Peptidase C53 # | |||||||||
| ACT_SITE | 49 | 49 | For N-terminal protease activity | H | 1 | |||||||
| ACT_SITE | 69 | 69 | For N-terminal protease activity | C | 1 | |||||||
case <FTGroup:1>
end case
Additional information
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| Size range | 165-175 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P19711 (POLG_BVDVN) |
| Scope | Viruses; Pestivirus |
| Comments | None |
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UniProtKB rule member sequences
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