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annotation rule: PRU01224

General rule information [?]

Accession PRU01224
Dates 19-OCT-2018 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51876; PV_NPRO
Names Pestivirus N-terminal protease (Npro) domain; Peptidase C53 domain
Function The pestivirus N-terminal protease Npro is a cysteine autoprotease that cleaves between its own C-terminus and the N-terminus of the core protein. Following the first cleavage reaction, Npro does not possess any proteolytic trans-activity but acts as a viral immediate effector to modulate the host cell's antiviral defenses.

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ Contains: RecName: Full=N-terminal protease; Short=N-pro; EC 3.4.22.-; AltName: Full=Autoprotease p20;

Gene Ontology [?]

GO:0019082; Biological process: viral protein processing.
GO:0004197; Molecular function: cysteine-type endopeptidase activity.

Keywords [?]

end case


Features [?]

From: PS51876
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C53 #        
ACT_SITE     49     49       For N-terminal protease activity     H   1
ACT_SITE     69     69       For N-terminal protease activity     C   1
case <FTGroup:1>
SITE     to     to+1       Cleavage; by autolysis     C-{P}  
end case


Additional information [?]

Size range 165-175 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P19711 (POLG_BVDVN)
Scope
Viruses; Pestivirus
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Viruses [5]