ProRule PRU01224
General rule information
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Accession | PRU01224 |
Dates | 19-OCT-2018 (Created)
22-NOV-2019 (Last updated, Version 2) |
Data class | Domain; |
Predictors |
PROSITE; PS51876; PV_NPRO |
Name | Pestivirus N-terminal protease (Npro) domain |
Function | The pestivirus N-terminal protease Npro is a cysteine autoprotease that cleaves between its own C-terminus and the N-terminus of the core protein. Following the first cleavage reaction, Npro does not possess any proteolytic trans-activity but acts as a viral immediate effector to modulate the host cell's antiviral defenses. |
Scope(s) |
Viruses Pestivirus |
Example(s) | P19711 (POLG_BVDVN); |
Propagated annotation
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Identifier, protein and gene names
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case <FTGroup:1> | |
Protein name | + Contains: RecName: Full=N-terminal protease; Short=N-pro; EC=3.4.22.-; AltName: Full=Autoprotease p20; |
Keywords
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Hydrolase | |
Protease | |
Thiol protease | |
end case | |
Inhibition of host IRF3 by virus | |
Inhibition of host RLR pathway by virus | |
Inhibition of host innate immune response by virus |
Gene Ontology
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GO:0019082; Biological process:viral protein processing |
GO:0004197; Molecular function:cysteine-type endopeptidase activity |
Features
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From: PS51876 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Peptidase C53 #" | |||||||||
ACT_SITE | 49 | 49 | /note="For N-terminal protease activity" | H | 1 | |||||||
ACT_SITE | 69 | 69 | /note="For N-terminal protease activity" | C | 1 | |||||||
case <FTGroup:1> | ||||||||||||
SITE | to | to+1 | /note="Cleavage; by autolysis" | C-{P} | ||||||||
end case |
Additional information
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Size range | 165-175 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [5] All [ 5 ]
- Retrieve set of proteins with 3D structure for this domain