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ProRule PRU01224


General rule information [?]

Accession PRU01224
Dates 19-OCT-2018 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51876; PV_NPRO
Name Pestivirus N-terminal protease (Npro) domain
Function The pestivirus N-terminal protease Npro is a cysteine autoprotease that cleaves between its own C-terminus and the N-terminus of the core protein. Following the first cleavage reaction, Npro does not possess any proteolytic trans-activity but acts as a viral immediate effector to modulate the host cell's antiviral defenses.
Scope(s) Viruses
Pestivirus
Example(s) P19711 (POLG_BVDVN);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + Contains:
RecName: Full=N-terminal protease;
                 Short=N-pro;
                 EC=3.4.22.-;
AltName: Full=Autoprotease p20;

Keywords [?]

Hydrolase
Protease
Thiol protease
end case
Inhibition of host IRF3 by virus
Inhibition of host RLR pathway by virus
Inhibition of host innate immune response by virus

Gene Ontology [?]

GO:0019082; Biological process:viral protein processing
GO:0004197; Molecular function:cysteine-type endopeptidase activity

Features [?]

From: PS51876
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C53 #"
ACT_SITE 49 49 /note="For N-terminal protease activity" H 1
ACT_SITE 69 69 /note="For N-terminal protease activity" C 1
case <FTGroup:1>
SITE to to+1 /note="Cleavage; by autolysis" C-{P}
end case

Additional information [?]

Size range 165-175 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]