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annotation rule: PRU01233

General rule information [?]

Accession PRU01233
Dates 7-FEB-2019 (Created)
7-FEB-2019 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51885; NEPRILYSIN
Name Neprilysin-like (M13) protease domain
Function The neprilysin (M13) family of endopeptidases are zinc- metalloenzymes, the majority of which are type II integral membrane proteins with their active sites facing the extracellular environment.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the peptidase M13 family.

Cross-references [?]

case <FTGroup:1> and <FTGroup:2>
PROSITE PS00142; ZINC_PROTEASE; 1;

Gene Ontology [?]

GO:0004222; Molecular function: metalloendopeptidase activity.

Keywords [?]

end case

case <FTGroup:2>
end case

case <FTTag:disulf>
end case


Features [?]

From: PS51885
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase M13 #        
ACT_SITE     510     510             E   1
ACT_SITE     575     575       Proton donor     D   1
METAL     509     509       Zinc; catalytic     H   2
METAL     513     513       Zinc; catalytic     H   2
METAL     571     571       Zinc; catalytic     E   2
DISULFID     2     7           disulf   C-x*-C  
DISULFID     25     659           disulf   C-x*-C  
DISULFID     33     619           disulf   C-x*-C  
DISULFID     89     338           disulf   C-x*-C  
DISULFID     175     183           disulf   C-x*-C  
DISULFID     546     671           disulf   C-x*-C  

Additional information [?]

Size range 600-800 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C2B4 (PEPO_LACLC)
Scope
Eukaryota; Metazoa
Bacteria; Lactobacillales
Viruses; Mimivirus
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]