PROSITE logo

ProRule PRU01233


General rule information [?]

Accession PRU01233
Dates 7-FEB-2019 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51885; NEPRILYSIN
Name Neprilysin-like (M13) protease domain
Function The neprilysin (M13) family of endopeptidases are zinc- metalloenzymes, the majority of which are type II integral membrane proteins with their active sites facing the extracellular environment.
Scope(s) Eukaryota
Metazoa
Bacteria
Lactobacillales
Viruses
Mimivirus
Example(s) P0C2B4 (PEPO_LACLC);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the peptidase M13 family.

Keywords [?]

Hydrolase
Metalloprotease
Protease
end case
case <FTGroup:2>
Metal-binding
Zinc
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0004222; Molecular function:metalloendopeptidase activity

Cross-references [?]

PROSITE PS00142; ZINC_PROTEASE; 1;

Features [?]

From: PS51885
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase M13 #"
ACT_SITE 510 510 E 1
ACT_SITE 575 575 /note="Proton donor" D 1
BINDING 509 509 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 2
BINDING 513 513 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 2
BINDING 571 571 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 E 2
DISULFID 2 7 disulf C-x*-C
DISULFID 25 659 disulf C-x*-C
DISULFID 33 619 disulf C-x*-C
DISULFID 89 338 disulf C-x*-C
DISULFID 175 183 disulf C-x*-C
DISULFID 546 671 disulf C-x*-C

Additional information [?]

Size range 600-800 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



View rule in raw text format (no links)

UniProtKB rule member sequences [?]