ProRule PRU01233

Accession	PRU01233
Dates	7-FEB-2019 (Created) 19-NOV-2022 (Last updated, Version 4)
Data class	Domain;
Predictors	PROSITE; PS51885; NEPRILYSIN
Name	Neprilysin-like (M13) protease domain
Function	The neprilysin (M13) family of endopeptidases are zinc- metalloenzymes, the majority of which are type II integral membrane proteins with their active sites facing the extracellular environment.
Scope(s)	Eukaryota Metazoa Bacteria Lactobacillales Viruses Mimivirus
Example(s)	P0C2B4 (PEPO_LACLC);

From: PS51885
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="Peptidase M13 #"
ACT_SITE	510	510			E	1
ACT_SITE	575	575	/note="Proton donor"		D	1
BINDING	509	509	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic"		H	2
BINDING	513	513	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic"		H	2
BINDING	571	571	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic"		E	2
DISULFID	2	7		disulf	C-x*-C
DISULFID	25	659		disulf	C-x*-C
DISULFID	33	619		disulf	C-x*-C
DISULFID	89	338		disulf	C-x*-C
DISULFID	175	183		disulf	C-x*-C
DISULFID	546	671		disulf	C-x*-C