 |
|
| annotation rule: PRU01237 |
General rule information
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| Accession | PRU01237 |
| Dates | 5-APR-2019 (Created) 22-NOV-2019 (Last updated, Version 2) |
| Data class | Domain |
| Predictors | PROSITE; PS51889; RUBV_NS_PRO |
| Name | Rubella virus (RUBV) nonstructural (NS) protease domain |
| Function | This RUBV NS protease domain is a papain-like protease with catalytic dyad of Cys and His. |
Propagated annotation
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Comments
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case <FTGroup:2>
| Cofactor | Zn(2+) Note: Zn(2+) is necessary for the protease activity. The protease can also function efficiently with Cd(2+) and Co(2+) |
end case
| Ptm | Non-structural polyprotein p200: Specific enzymatic cleavage by its own cysteine protease yield mature proteins p150 and p90. |
Gene Ontology
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case <FTGroup:2>
GO:0046872; Molecular function: metal ion binding.
end case
case <FTGroup:1>
GO:0004197; Molecular function: cysteine-type endopeptidase activity.
Keywords
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end case
case <FTGroup:2>
end case
Features
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| From: PS51889 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Peptidase C27 # | |||||||||
| REGION | 153 | 184 | Interaction with host CALM1 | |||||||||
| REGION | 194 | 229 | EF-hand-like | |||||||||
| ACT_SITE | 153 | 153 | For cysteine protease activity | C | 1 | |||||||
| ACT_SITE | 274 | 274 | For cysteine protease activity | H | 1 | |||||||
| METAL | 176 | 176 | Zinc | C | 2 | |||||||
| METAL | 179 | 179 | Zinc | C | 2 | |||||||
| METAL | 228 | 228 | Zinc | C | 2 | |||||||
| METAL | 274 | 274 | Zinc | H | 2 | |||||||
case <FTGroup:1>
end case
Additional information
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| Size range | 295-310 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q86500 (POLN_RUBVM) |
| Scope | Viruses; Rubivirus |
| Comments | None |
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UniProtKB rule member sequences
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