General rule information
[?]
Accession |
PRU01237 |
Dates |
5-APR-2019 (Created) 22-NOV-2019 (Last updated, Version 2) |
Predictors |
PROSITE; PS51889; RUBV_NS_PRO
|
Name |
Rubella virus (RUBV) nonstructural (NS) protease domain |
Function |
This RUBV NS protease domain is a papain-like protease with catalytic dyad of Cys and His. |
Propagated annotation
[?]
case <FTGroup:2>
Cofactor |
Zn(2+) Note: Zn(2+) is necessary for the protease activity. The protease can also function efficiently with Cd(2+) and Co(2+) |
end case
Ptm |
Non-structural polyprotein p200: Specific enzymatic cleavage by its own cysteine protease yield mature proteins p150 and p90. |
case <FTGroup:2>
GO:0046872; Molecular function: metal ion binding.
end case
case <FTGroup:1>
GO:0004197; Molecular function: cysteine-type endopeptidase activity.
end case
case <FTGroup:2>
end case
From: PS51889 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
Peptidase C27 #
|
|
|
|
|
|
|
REGION
|
|
153
|
|
184
|
|
Interaction with host CALM1
|
|
|
|
|
|
|
REGION
|
|
194
|
|
229
|
|
EF-hand-like
|
|
|
|
|
|
|
ACT_SITE
|
|
153
|
|
153
|
|
For cysteine protease activity
|
|
|
|
C
|
|
1
|
ACT_SITE
|
|
274
|
|
274
|
|
For cysteine protease activity
|
|
|
|
H
|
|
1
|
METAL
|
|
176
|
|
176
|
|
Zinc
|
|
|
|
C
|
|
2
|
METAL
|
|
179
|
|
179
|
|
Zinc
|
|
|
|
C
|
|
2
|
METAL
|
|
228
|
|
228
|
|
Zinc
|
|
|
|
C
|
|
2
|
METAL
|
|
274
|
|
274
|
|
Zinc
|
|
|
|
H
|
|
2
|
case <FTGroup:1>
SITE
|
|
to
|
|
to+1
|
|
Cleavage; autocatalytic
|
|
|
|
G-G
|
|
|
end case
Additional information
[?]
Size range |
295-310 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q86500 (POLN_RUBVM) |
Scope |
Viruses; Rubivirus |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]
UniProtKB/Swiss-Prot sets