ProRule PRU01237
General rule information
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Accession | PRU01237 |
Dates | 5-APR-2019 (Created)
19-NOV-2022 (Last updated, Version 4) |
Data class | Domain; |
Predictors |
PROSITE; PS51889; RUBV_NS_PRO |
Name | Rubella virus (RUBV) nonstructural (NS) protease domain |
Function | This RUBV NS protease domain is a papain-like protease with catalytic dyad of Cys and His. |
Scope(s) |
Viruses Rubivirus |
Example(s) | Q86500 (POLN_RUBVM); |
Propagated annotation
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Comments
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case <FTGroup:2> | |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Zn(2+) is necessary for the protease activity. The protease can also function efficiently with Cd(2+) and Co(2+) |
end case | |
PTM | Non-structural polyprotein p200: Specific enzymatic cleavage by its own cysteine protease yield mature proteins p150 and p90. |
Keywords
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Hydrolase | |
Protease | |
Thiol protease | |
end case | |
case <FTGroup:2> | |
Metal-binding | |
Zinc | |
end case |
Gene Ontology
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case <FTGroup:2> | |
GO:0046872; Molecular function:metal ion binding | |
end case | |
case <FTGroup:1> | |
GO:0004197; Molecular function:cysteine-type endopeptidase activity |
Features
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From: PS51889 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Peptidase C27 #" | |||||||||
REGION | 153 | 184 | /note="Interaction with host CALM1" | |||||||||
REGION | 194 | 229 | /note="EF-hand-like" | |||||||||
ACT_SITE | 153 | 153 | /note="For cysteine protease activity" | C | 1 | |||||||
ACT_SITE | 274 | 274 | /note="For cysteine protease activity" | H | 1 | |||||||
BINDING | 176 | 176 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 2 | |||||||
BINDING | 179 | 179 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 2 | |||||||
BINDING | 228 | 228 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 2 | |||||||
BINDING | 274 | 274 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 2 | |||||||
case <FTGroup:1> | ||||||||||||
SITE | to | to+1 | /note="Cleavage; autocatalytic" | G-G | ||||||||
end case |
Additional information
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Size range | 295-310 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [9] All [ 9 ]
- Retrieve set of proteins with 3D structure for this domain