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General rule information [?]

Accession PRU01237
Dates 5-APR-2019 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51889; RUBV_NS_PRO
Name Rubella virus (RUBV) nonstructural (NS) protease domain
Function This RUBV NS protease domain is a papain-like protease with catalytic dyad of Cys and His.

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
Cofactor Zn(2+)
Note: Zn(2+) is necessary for the protease activity. The protease can also function efficiently with Cd(2+) and Co(2+)
end case

Ptm Non-structural polyprotein p200: Specific enzymatic cleavage by its own cysteine protease yield mature proteins p150 and p90.

Gene Ontology [?]

case <FTGroup:2>
GO:0046872; Molecular function: metal ion binding.
end case

case <FTGroup:1>
GO:0004197; Molecular function: cysteine-type endopeptidase activity.

Keywords [?]

end case

case <FTGroup:2>
end case

Features [?]

From: PS51889
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C27 #        
REGION     153     184       Interaction with host CALM1        
REGION     194     229       EF-hand-like        
ACT_SITE     153     153       For cysteine protease activity     C   1
ACT_SITE     274     274       For cysteine protease activity     H   1
BINDING     176     176       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   2
BINDING     179     179       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   2
BINDING     228     228       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   2
BINDING     274     274       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     H   2
case <FTGroup:1>
SITE     to     to+1       Cleavage; autocatalytic     G-G  
end case

Additional information [?]

Size range 295-310 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q86500 (POLN_RUBVM)
Viruses; Rubivirus
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]