PRU01237
General rule information
[?]
Accession | PRU01237 |
Dates | 5-APR-2019 (Created) 19-NOV-2022 (Last updated, Version 4) |
Data class | Domain |
Predictors | PROSITE; PS51889; RUBV_NS_PRO |
Name | Rubella virus (RUBV) nonstructural (NS) protease domain |
Function | This RUBV NS protease domain is a papain-like protease with catalytic dyad of Cys and His. |
Propagated annotation
[?]
Comments
[?]
case <FTGroup:2>
Cofactor | Zn(2+) Note: Zn(2+) is necessary for the protease activity. The protease can also function efficiently with Cd(2+) and Co(2+) |
end case
Ptm | Non-structural polyprotein p200: Specific enzymatic cleavage by its own cysteine protease yield mature proteins p150 and p90. |
Gene Ontology
[?]
case <FTGroup:2>
GO:0046872; Molecular function: metal ion binding.
end case
case <FTGroup:1>
GO:0004197; Molecular function: cysteine-type endopeptidase activity.
Keywords
[?]
end case
case <FTGroup:2>
end case
Features
[?]
From: PS51889 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Peptidase C27 # | |||||||||
REGION | 153 | 184 | Interaction with host CALM1 | |||||||||
REGION | 194 | 229 | EF-hand-like | |||||||||
ACT_SITE | 153 | 153 | For cysteine protease activity | C | 1 | |||||||
ACT_SITE | 274 | 274 | For cysteine protease activity | H | 1 | |||||||
BINDING | 176 | 176 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 2 | |||||||
BINDING | 179 | 179 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 2 | |||||||
BINDING | 228 | 228 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 2 | |||||||
BINDING | 274 | 274 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 2 |
case <FTGroup:1>
end case
Additional information
[?]
Size range | 295-310 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q86500 (POLN_RUBVM) |
Scope | Viruses; Rubivirus |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
-
UniProtKB/Swiss-Prot sets
Viruses [9]
- Retrieve set of proteins with 3D structure for this domain