PRU01237

General rule information [?]

Accession	PRU01237
Dates	5-APR-2019 (Created) 19-NOV-2022 (Last updated, Version 4)

Data class

Domain

Predictors

PROSITE; PS51889; RUBV_NS_PRO

Name	Rubella virus (RUBV) nonstructural (NS) protease domain

Function

This RUBV NS protease domain is a papain-like protease with catalytic dyad of Cys and His.

Propagated annotation [?]

Comments [?]

case <FTGroup:2>

Cofactor

Zn(2+)
Note: Zn(2+) is necessary for the protease activity. The protease can also function efficiently with Cd(2+) and Co(2+)

end case

Ptm	Non-structural polyprotein p200: Specific enzymatic cleavage by its own cysteine protease yield mature proteins p150 and p90.

Gene Ontology [?]

case <FTGroup:2>

GO:0046872; Molecular function: metal ion binding.

end case

case <FTGroup:1>

GO:0004197; Molecular function: cysteine-type endopeptidase activity.

Keywords [?]

Hydrolase
Protease
Thiol protease

end case

case <FTGroup:2>

Metal-binding
Zinc

end case

Features [?]

From: PS51889

Key From To Description Tag Condition FTGroup

DOMAIN from to Peptidase C27 #

REGION 153 184 Interaction with host CALM1

REGION 194 229 EF-hand-like

ACT_SITE 153 153 For cysteine protease activity C 1

ACT_SITE 274 274 For cysteine protease activity H 1

BINDING 176 176 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 2

BINDING 179 179 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 2

BINDING 228 228 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 2

BINDING 274 274 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 2

case <FTGroup:1>

SITE to to+1 Cleavage; autocatalytic G-G

end case

Additional information [?]

Size range	295-310 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q86500 (POLN_RUBVM)
Scope	Viruses; Rubivirus
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Viruses [9]
Retrieve set of proteins with 3D structure for this domain