General rule information
[?]
Accession |
PRU01239 |
Dates |
18-APR-2019 (Created) 22-NOV-2019 (Last updated, Version 2) |
Predictors |
PROSITE; PS51891; CENPV_GFA
|
Function |
At the C-terminal end, CENP-V possesses an evolutionally conserved domain that comprises an array of seven cysteines and shows high structural similarity to glutathione-dependent formaldehyde-activating enzyme (Gfa), an enzyme responsible for formaldehyde detoxification in prokaryotes. CENP-V could be an enzyme that scavenges the formaldehyde produced in histone demethylation reactions. |
Propagated annotation
[?]
case <FTGroup:1> and <FTGroup:2>
Cofactor |
Zn(2+) Note: Binds 2 Zn(2+) ions per subunit |
else case <FTGroup:2>
end case
case <FTGroup:1> or <FTGroup:2>
end case
From: PS51891 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
CENP-V/GFA
|
|
|
|
|
|
|
METAL
|
|
5
|
|
5
|
|
Zinc #1; structural
|
|
|
|
C
|
|
1
|
METAL
|
|
7
|
|
7
|
|
Zinc #1; structural
|
|
|
|
C
|
|
1
|
METAL
|
|
26
|
|
26
|
|
Zinc #2; catalytic
|
|
|
|
C
|
|
2
|
METAL
|
|
28
|
|
28
|
|
Zinc #2; catalytic
|
|
|
|
C
|
|
2
|
METAL
|
|
31
|
|
31
|
|
Zinc #2; catalytic
|
|
|
|
C
|
|
2
|
METAL
|
|
72
|
|
72
|
|
Zinc #1; structural
|
|
|
|
C
|
|
1
|
METAL
|
|
75
|
|
75
|
|
Zinc #1; structural
|
|
|
|
C
|
|
1
|
Additional information
[?]
Size range |
110-155 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q7Z7K6 (CENPV_HUMAN) |
Scope |
Eukaryota
Bacteria; Proteobacteria |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]