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General rule information [?]

Accession PRU01239
Dates 18-APR-2019 (Created)
26-JAN-2023 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51891; CENPV_GFA
Name CENP-V/GFA domain
Function At the C-terminal end, CENP-V possesses an evolutionally conserved domain that comprises an array of seven cysteines and shows high structural similarity to glutathione-dependent formaldehyde-activating enzyme (Gfa), an enzyme responsible for formaldehyde detoxification in prokaryotes. CENP-V could be an enzyme that scavenges the formaldehyde produced in histone demethylation reactions.

Propagated annotation [?]

Comments [?]

case <FTGroup:1> and <FTGroup:2>
Cofactor Zn(2+)
Note: Binds 2 Zn(2+) ions per subunit
else case <FTGroup:2>
Cofactor Zn(2+)
end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

end case

Features [?]

From: PS51891
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       CENP-V/GFA        
BINDING     5     5       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural     C   1
BINDING     7     7       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural     C   1
BINDING     26     26       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic     C   2
BINDING     28     28       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic     C   2
BINDING     31     31       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic     C   2
BINDING     72     72       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural     C   1
BINDING     75     75       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural     C   1

Additional information [?]

Size range 110-155 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q7Z7K6 (CENPV_HUMAN)
Bacteria; Pseudomonadota
Comments None


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UniProtKB rule member sequences [?]