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annotation rule: PRU01239

General rule information [?]

Accession PRU01239
Dates 18-APR-2019 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51891; CENPV_GFA
Name CENP-V/GFA domain
Function At the C-terminal end, CENP-V possesses an evolutionally conserved domain that comprises an array of seven cysteines and shows high structural similarity to glutathione-dependent formaldehyde-activating enzyme (Gfa), an enzyme responsible for formaldehyde detoxification in prokaryotes. CENP-V could be an enzyme that scavenges the formaldehyde produced in histone demethylation reactions.

Propagated annotation [?]


Comments [?]

case <FTGroup:1> and <FTGroup:2>
Cofactor Zn(2+)
Note: Binds 2 Zn(2+) ions per subunit
else case <FTGroup:2>
Cofactor Zn(2+)
end case


Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

end case


Features [?]

From: PS51891
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       CENP-V/GFA        
METAL     5     5       Zinc #1; structural     C   1
METAL     7     7       Zinc #1; structural     C   1
METAL     26     26       Zinc #2; catalytic     C   2
METAL     28     28       Zinc #2; catalytic     C   2
METAL     31     31       Zinc #2; catalytic     C   2
METAL     72     72       Zinc #1; structural     C   1
METAL     75     75       Zinc #1; structural     C   1

Additional information [?]

Size range 110-155 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q7Z7K6 (CENPV_HUMAN)
Scope
Eukaryota
Bacteria; Proteobacteria
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Bacteria [15]
Eukaryota [21]
All [ 36 ]