PRU01239

General rule information [?]

Accession	PRU01239
Dates	18-APR-2019 (Created) 26-JAN-2023 (Last updated, Version 5)

Data class

Domain

Predictors

PROSITE; PS51891; CENPV_GFA

Name	CENP-V/GFA domain

Function

At the C-terminal end, CENP-V possesses an evolutionally conserved domain that comprises an array of seven cysteines and shows high structural similarity to glutathione-dependent formaldehyde-activating enzyme (Gfa), an enzyme responsible for formaldehyde detoxification in prokaryotes. CENP-V could be an enzyme that scavenges the formaldehyde produced in histone demethylation reactions.

Propagated annotation [?]

Comments [?]

case <FTGroup:1> and <FTGroup:2>

Cofactor

Zn(2+)
Note: Binds 2 Zn(2+) ions per subunit

else case <FTGroup:2>

Cofactor

Zn(2+)

end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>

GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Metal-binding
Zinc

end case

Features [?]

From: PS51891

Key From To Description Tag Condition FTGroup

DOMAIN from to CENP-V/GFA

BINDING 5 5 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural C 1

BINDING 7 7 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural C 1

BINDING 26 26 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic C 2

BINDING 28 28 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic C 2

BINDING 31 31 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic C 2

BINDING 72 72 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural C 1

BINDING 75 75 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural C 1

Additional information [?]

Size range	110-155 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q7Z7K6 (CENPV_HUMAN)
Scope	Eukaryota Bacteria; Pseudomonadota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Bacteria [15]

Eukaryota [21]

All [ 36 ]
Retrieve set of proteins with 3D structure for this domain

Bacteria	[15]
Eukaryota	[21]
All	[ 36 ]