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ProRule PRU01239


General rule information [?]

Accession PRU01239
Dates 18-APR-2019 (Created)
26-JAN-2023 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51891; CENPV_GFA
Name CENP-V/GFA domain
Function At the C-terminal end, CENP-V possesses an evolutionally conserved domain that comprises an array of seven cysteines and shows high structural similarity to glutathione-dependent formaldehyde-activating enzyme (Gfa), an enzyme responsible for formaldehyde detoxification in prokaryotes. CENP-V could be an enzyme that scavenges the formaldehyde produced in histone demethylation reactions.
Scope(s) Eukaryota
Bacteria
Pseudomonadota
Example(s) Q7Z7K6 (CENPV_HUMAN);

Propagated annotation [?]

Comments [?]

case <FTGroup:1> and <FTGroup:2>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit
else case <FTGroup:2>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
end case

Keywords [?]

Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51891
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CENP-V/GFA"
BINDING 5 5 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="structural"		 C 1
BINDING 7 7 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="structural"		 C 1
BINDING 26 26 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
/ligand_note="catalytic"		 C 2
BINDING 28 28 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
/ligand_note="catalytic"		 C 2
BINDING 31 31 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
/ligand_note="catalytic"		 C 2
BINDING 72 72 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="structural"		 C 1
BINDING 75 75 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="structural"		 C 1

Additional information [?]

Size range 110-155 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]