ProRule PRU01239
General rule information
[?]
Accession | PRU01239 |
Dates | 18-APR-2019 (Created)
26-JAN-2023 (Last updated, Version 5) |
Data class | Domain; |
Predictors |
PROSITE; PS51891; CENPV_GFA |
Name | CENP-V/GFA domain |
Function | At the C-terminal end, CENP-V possesses an evolutionally conserved domain that comprises an array of seven cysteines and shows high structural similarity to glutathione-dependent formaldehyde-activating enzyme (Gfa), an enzyme responsible for formaldehyde detoxification in prokaryotes. CENP-V could be an enzyme that scavenges the formaldehyde produced in histone demethylation reactions. |
Scope(s) |
Eukaryota Bacteria Pseudomonadota |
Example(s) | Q7Z7K6 (CENPV_HUMAN); |
Propagated annotation
[?]
Comments
[?]
case <FTGroup:1> and <FTGroup:2> | |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit |
else case <FTGroup:2> | |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; |
end case |
Keywords
[?]
Metal-binding | |
Zinc | |
end case |
Gene Ontology
[?]
case <FTGroup:1> or <FTGroup:2> | |
GO:0008270; Molecular function:zinc ion binding |
Features
[?]
From: PS51891 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="CENP-V/GFA" | |||||||||
BINDING | 5 | 5 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural" |
C | 1 | |||||||
BINDING | 7 | 7 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural" |
C | 1 | |||||||
BINDING | 26 | 26 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic" |
C | 2 | |||||||
BINDING | 28 | 28 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic" |
C | 2 | |||||||
BINDING | 31 | 31 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic" |
C | 2 | |||||||
BINDING | 72 | 72 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural" |
C | 1 | |||||||
BINDING | 75 | 75 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="structural" |
C | 1 |
Additional information
[?]
Size range | 110-155 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Bacteria [15] Eukaryota [21] All [ 36 ]
- Retrieve set of proteins with 3D structure for this domain