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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01239


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01239
General rule information [?]

Accession PRU01239
Dates 18-APR-2019 (Created)
26-JAN-2023 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51891; CENPV_GFA
Name CENP-V/GFA domain
Function At the C-terminal end, CENP-V possesses an evolutionally conserved domain that comprises an array of seven cysteines and shows high structural similarity to glutathione-dependent formaldehyde-activating enzyme (Gfa), an enzyme responsible for formaldehyde detoxification in prokaryotes. CENP-V could be an enzyme that scavenges the formaldehyde produced in histone demethylation reactions.
Scope(s) Eukaryota
Bacteria
Pseudomonadota
Example(s) Q7Z7K6;

Propagated annotation [?]

Comments [?]

case <FTGroup:1> and <FTGroup:2>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit
else case <FTGroup:2>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
end case

Keywords [?]

Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51891
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CENP-V/GFA"
BINDING 5 5 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="structural"		 C 1
BINDING 7 7 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="structural"		 C 1
BINDING 26 26 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
/ligand_note="catalytic"		 C 2
BINDING 28 28 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
/ligand_note="catalytic"		 C 2
BINDING 31 31 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
/ligand_note="catalytic"		 C 2
BINDING 72 72 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="structural"		 C 1
BINDING 75 75 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="structural"		 C 1

Additional information [?]

Size range 110-155 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]