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General rule information [?]

Accession PRU01242
Dates 10-MAY-2019 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51894; CV_3CL_PRO
Name Caliciviridae (CV) 3C-like protease (3CLpro) domain
Function The generation of mature Caliciviridae proteins requires that proteolytic clevages be effected at specific sites of the large polyprotein translated from the viral genomic RNA. This polyprotein processing is carried out by a 3C-like cysteine protease (3CLpro). The CV 3CLpro domain is predicted to contain a catalytic triad constituted of His, Asp and Cys residues, where the Cys likely represents the nucleophilic residue and Asp the acidic residue.

Propagated annotation [?]

Description [?]

+ RecName: EC;

Comments [?]

case <FTGroup:1>
Catalytic activity Reaction=Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.; EC=;

Gene Ontology [?]

GO:0004197; Molecular function: cysteine-type endopeptidase activity.

Keywords [?]

end case

Features [?]

From: PS51894
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C24        
ACT_SITE     32     32       For 3CLpro activity     H   1
ACT_SITE     53     53       For 3CLpro activity     [DE]   1
ACT_SITE     116     116       For 3CLpro activity     C   1

Additional information [?]

Size range 130-160 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9QEJ5 (POLG_PESV)
Viruses; Caliciviridae
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Viruses [20]