ProRule PRU01242
General rule information
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Accession | PRU01242 |
Dates | 10-MAY-2019 (Created)
22-NOV-2019 (Last updated, Version 2) |
Data class | Domain; |
Predictors |
PROSITE; PS51894; CV_3CL_PRO |
Name | Caliciviridae (CV) 3C-like protease (3CLpro) domain |
Function | The generation of mature Caliciviridae proteins requires that proteolytic clevages be effected at specific sites of the large polyprotein translated from the viral genomic RNA. This polyprotein processing is carried out by a 3C-like cysteine protease (3CLpro). The CV 3CLpro domain is predicted to contain a catalytic triad constituted of His, Asp and Cys residues, where the Cys likely represents the nucleophilic residue and Asp the acidic residue. |
Scope(s) |
Viruses Caliciviridae |
Example(s) | Q9QEJ5 (POLG_PESV); |
Propagated annotation
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Identifier, protein and gene names
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Protein name | + RecName: EC=3.4.22.66; |
case <FTGroup:1> |
Comments
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case <FTGroup:1> | |
CATALYTIC ACTIVITY | Reaction=Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.; EC=3.4.22.66; |
Keywords
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Hydrolase | |
Protease | |
Thiol protease | |
end case |
Gene Ontology
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GO:0004197; Molecular function:cysteine-type endopeptidase activity |
Features
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From: PS51894 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Peptidase C24" | |||||||||
ACT_SITE | 32 | 32 | /note="For 3CLpro activity" | H | 1 | |||||||
ACT_SITE | 53 | 53 | /note="For 3CLpro activity" | [DE] | 1 | |||||||
ACT_SITE | 116 | 116 | /note="For 3CLpro activity" | C | 1 |
Additional information
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Size range | 130-160 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [21] All [ 21 ]
- Retrieve set of proteins with 3D structure for this domain