ProRule PRU01244

Accession	PRU01244
Dates	05-JUN-2019 (Created) 20-OCT-2025 (Last updated, Version )
Data class	Domain;
Predictors	PROSITE; PS51896; ZF_C4H2
Name	Zinc finger C4H2-type
Function	ZC4H2, which belongs to a conserved gene family found in all metazoans, plays an important role during embryonic development of the central and peripheral nervous systems. The ZC4H2 gene encodes a zinc-finger protein with a C-terminal domain, which includes a putative C4H2 zinc-finger characterized by four cysteine residues and two histidine residues, and a coiled-coil domain.
Scope(s)	Eukaryota Metazoa
Example(s)	Q9NQZ6;

From: PS51896
Key	From	To	Description	Tag	Condition	FTGroup
case <Feature:PS51896:9=C> and <Feature:PS51896:12=C> and <Feature:PS51896:13=H> and <Feature:PS51896:17=H> and <Feature:PS51896:23=C> and <Feature:PS51896:26=C>
ZN_FING	6	32	/note="C4H2-type #"
else case <Feature:PS51896:9=[CH]> and <Feature:PS51896:12=[CH]> and <Feature:PS51896:13=[CH]> and <Feature:PS51896:17=[CH]> and <Feature:PS51896:33=[CH]> and <Feature:PS51896:26=[CH]>
ZN_FING	6	32	/note="C4H2-type #; atypical"
else
ZN_FING	6	32	/note="C4H2-type #; degenerate"
end case
BINDING	9	9	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	12	12	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	23	23	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	26	26	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1