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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01244


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01244
General rule information [?]

Accession PRU01244
Dates 05-JUN-2019 (Created)
22-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51896; ZF_C4H2
Name Zinc finger C4H2-type
Function ZC4H2, which belongs to a conserved gene family found in all metazoans, plays an important role during embryonic development of the central and peripheral nervous systems. The ZC4H2 gene encodes a zinc-finger protein with a C-terminal domain, which includes a putative C4H2 zinc-finger characterized by four cysteine residues and two histidine residues, and a coiled-coil domain.
Scope(s) Eukaryota
Metazoa
Example(s) Q68FG0;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
Zinc-finger
end case

Gene Ontology [?]

case <Feature:PS51896:9=[CH]> and <Feature:PS51896:12=[CH]> and <Feature:PS51896:13=[CH]> and <Feature:PS51896:17=[CH]> and <Feature:PS51896:33=[CH]> and <Feature:PS51896:26=[CH]>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51896
Key From To Description Tag Condition FTGroup
case <Feature:PS51896:9=C> and <Feature:PS51896:12=C> and <Feature:PS51896:13=H> and <Feature:PS51896:17=H> and <Feature:PS51896:23=C> and <Feature:PS51896:26=C>
ZN_FING 9 26 /note="C4H2-type #"
else case <Feature:PS51896:9=[CH]> and <Feature:PS51896:12=[CH]> and <Feature:PS51896:13=[CH]> and <Feature:PS51896:17=[CH]> and <Feature:PS51896:33=[CH]> and <Feature:PS51896:26=[CH]>
ZN_FING 9 26 /note="C4H2-type #; atypical"
else
ZN_FING 9 26 /note="C4H2-type #; degenerate"
end case

Additional information [?]

Size range 40-45 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]