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PROSITE entry PS51896


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General information about the entry

Entry name [info] ZF_C4H2
Accession [info] PS51896
Entry type [info] MATRIX
Date [info] 31-JUL-2019 CREATED;
07-APR-2021 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51896
Associated ProRule [info] PRU01244

Name and characterization of the entry

Description [info] Zinc finger C4H2-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=43;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=39;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.4182392; R2=0.0067978; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4984.5571289; R2=5.5880079; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1336; H_SCORE=12450; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=748; H_SCORE=9164; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-6; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='H';  M=  3,-16,-27,-16, -4,-15,-26, 24,  2,-12, -6,  1,-14,-12, 19,  5,-10, -1,  0,-27,  0,  4;
/M: SY='Q';  M=  6,-14,-20,-21,  1,-19,-16, -7, 10, -7, -5, -3, -6,-11, 43,  8,-10,  0, -4,-17,-10, 14;
/M: SY='P';  M= -5,-15,-28, -8,  8,-33, -8,  5,-25,  8,-28,-35,-23, 80, -2,-10,  2,  5,-33,-30,-20, -2;
/M: SY='P';  M= -3,-20,-26,-17,  3,-33,-14, 14,-15, 14,-11, -3,-19, 54, -4, -6,-14,  0,-25,-30,-16, -4;
/M: SY='P';  M=  9,-13,-30, -6,  6,-33, -6, -1,-19,  6,-23,-21,-19, 65,  4,-10, -3,  4,-21,-37,-27,  0;
/M: SY='M';  M= -1,-24,-24,-37,-21, 25,-24,  1,  6,  9, 20, 30, -4,-40,-17, -4,-16, -7,  4,-15,  5,-21;
/M: SY='Q';  M=  4, -4,-26, -4, 20,-17,-14,-13,-20, 25,-20,  9, -4,  6, 30, 17, -4, -6,-24,-16,-10, 21;
/M: SY='E';  M= 13,  0,-11,  1, 17,-26,-12,-11,-13,  5, -9, -5, -1,  0,  8,-15, 14, 11, -8,-32,-22, 14;
/M: SY='C';  M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30,  0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60,  0;
/M: SY='G';  M= -1, -6,-20,-10, -6,-11, 17,-15, -1,-11,  3, -2,-10,-15,  5, -8,-10, -7,-15, -6, -2, -1;
/M: SY='N';  M=  6, 15,-16,  4, -4,-10,  0,-10, -6,  0,-20,-13, 30,-17,-10,-14, 25, 16,-14,-45,-27,-10;
/M: SY='C';  M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30,  0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60,  0;
/M: SY='H';  M=-25,-22,-52,-18, -5,-15,-30,105,-18,-18,  0, 13,-17,  3, -2, -8,-12,-18,-20,-25, 22, -5;
/M: SY='Q';  M=  6,  9,-16, -3,  9,-23,-13, -4,-13,  0,-20, -6, 23,-11, 47, 11, -6,  4,-26,-32,-21, 21;
/M: SY='Q';  M=  6,  9,-16, -3,  9,-23,-13, -4,-13,  0,-20, -6, 23,-11, 47, 11, -6,  4,-26,-32,-21, 21;
/M: SY='I';  M=  0,-20,-20,-40,-30,  0,-10,-20, 60,-20, 20, 10,  0,-30,-20,-30,-10,  0, 40,-30,-10,-30;
/M: SY='H';  M=-20,-20,-50,-20,  0,-30,-30,140,-20,-20,-10, 20,-10, 10,  0,-10,-10,-20,-30,-50,  0,  0;
/M: SY='R';  M=-10,-16,-13,-10,-10,  1,-20,-10,-11, -1,  2,  7,-20,-17, 11, 43,-14,-19, -3, -7, 11, -4;
/M: SY='N';  M=  0, 40,-10, 10,-10,-10,  0,-10,  0,  0,-20,  0, 80,-30,-10,-20,  0, 10,-20,-70,-40,-10;
/M: SY='A';  M= 40,  0,-30,  0,  0,-20,  0,-20,  0,  0,-10, 10,  0,-10, 10,-10, 10, 10, 10,-50,-40,  0;
/M: SY='P';  M=-10,-20,-30,-10, 10,-40,-10, 10,-30, 10,-30,-40,-30,110,  0,-10,-10,  0,-40,-30,-20,  0;
/M: SY='I';  M=  4,-20,-20,-33,-30,  4,-17,-24, 53,-20, 16,  6, -7,-34,-24,-23,-10,  4, 44,-30, -3,-30;
/M: SY='C';  M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30,  0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60,  0;
/M: SY='P';  M= -3,-13,-26,-10, -1,-33,-14, -1,-19,  3,-19,-25,-15, 69,  0,-17,  1, 19,-21,-37,-16, -4;
/M: SY='H';  M= -9,-16,-24,-19, -6, -9,-24, 53,  3,-10, 16, 30,-11,-18,-10,-11,-16, -7, -7,-34,  9, -6;
/M: SY='C';  M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30,  0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60,  0;
/M: SY='K';  M= 15,  0,-30,  0, 13,-14, -6,-20,-13, 25,-16, 16,  0,  3,  4,  3,  4, -3, -9,-31,-21,  6;
/M: SY='A';  M= 33,  0,-28,  0,  0,-18,  0,-18, -2,  0,-12,  3,  0,-10,  5,-10, 17, 12,  5,-45,-35, -2;
/M: SY='K';  M=  0,  0,-30,  0, 20,-10,-10,-20,-20, 40,-20, 20,  0, 10,  0, 10,  0,-10,-20,-20,-10, 10;
/M: SY='S';  M= 10, -7,-20,-11, -4,-14, -7,  1, -3,  7, -5, 10,  0,-21,-10, -6, 18, 13, -6,-30,-16,-10;
/M: SY='R';  M= -6,-20,-20,-21,-17, -6,-16,-14,  3, -1, -5,  4,-13,-17, 11, 39,-10,-19,  9,-11, -4,-11;
/M: SY='S';  M= 21,  0,-24,  0,  0,-14,  0,-14, -6,  0,-16, -9,  0,-10, -3,-10, 29, 16, -3,-37,-27, -6;
/M: SY='R';  M= -4,  7,-19,  0, -3,-10,-10,-12,-16, 14,-20,  5, 22,-12,  8, 25, -4,-10,-16,-31,-17, -1;
/M: SY='N';  M=  0, 40,-10, 10,-10,-10,  0,-10,  0,  0,-20,  0, 80,-30,-10,-20,  0, 10,-20,-70,-40,-10;
/M: SY='P';  M=  9,-13,-30, -6,  6,-33, -6, -1,-19,  6,-23,-21,-19, 65,  4,-10, -3,  4,-21,-37,-27,  0;
/M: SY='K';  M=  0,  0,-30,  0, 20,-10,-10,-20,-20, 40,-20, 20,  0, 10,  0, 10,  0,-10,-20,-20,-10, 10;
/M: SY='N';  M=  0, 15,-23,  4,  9,-10, -6,-16,-13, 25,-20, 13, 30, -5, -4, -1,  0, -3,-20,-39,-21,  3;
/M: SY='P';  M= -6,-13,-34,-10, -1,-36, 23, -5,-23,  3,-26,-33,-19, 65, -7,-14, -6, -7,-36,-15,-24, -7;
/M: SY='K';  M= 15,  0,-30,  0, 13,-14, -6,-20,-13, 25,-16, 16,  0,  3,  4,  3,  4, -3, -9,-31,-21,  6;
/M: SY='R';  M= -5,  6,-18, -1, -5,-10,-11,-12,-17, 11,-20,  3, 21,-14, 10, 31, -5,-12,-15,-29,-17, -2;
/M: SY='K';  M=  4,  0,-26,  0, 13,-10, -6,-16,-16, 25,-20,  5,  0,  3, -4,  3, 15,  1,-16,-24,-14,  3;
/M: SY='D';  M= 17, 10,-21, 22, 17,-33,-10,-12,-19,  3,-12, -8, -1, -4, 21, -2,  2, -2,-13,-32,-23, 17;
/M: SY='Q';  M= 10,  3,-30, 12, 10,-32,-15, 15,-19, -3,-14, -4, -3, -3, 30,  5, -3, -3,-18,-33,-16, 15;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 3 in 3 different sequences
Number of true positive hits 3 in 3 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] ZN_FING
Feature description [info] C4H2-type
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
3 sequences

ZC4H2_DANRE (Q7T3I0), ZC4H2_HUMAN (Q9NQZ6), ZC4H2_MOUSE (Q68FG0)