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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01245


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01245
General rule information [?]

Accession PRU01245
Dates 19-JUN-2019 (Created)
22-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51897; ANNEXIN_2
Name Annexin repeat
Function Annexins are a group of calcium-binding proteins that associate reversibly with membranes. Each of these proteins consist of a unique N- terminal domain followed by four or eight copies (in annexin A6) of a conserved segment of approximately 70 residues. Each of the repeats has the potential to have a type II Ca(2+)-binding bipartite motif, located on two different alpha-helices (GxGT-(38-40 residues)-D/E), but typically some of them are non-functional.
Scope(s) Eukaryota
Example(s) P09525;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the annexin family.

Keywords [?]

Annexin
Calcium
Calcium/phospholipid-binding

Gene Ontology [?]

GO:0005509; Molecular function:calcium ion binding
GO:0005544; Molecular function:calcium-dependent phospholipid binding

Cross-references [?]

PROSITE PS00223; ANNEXIN_1; 4-8;

Features [?]

From: PS51897
Key From To Description Tag Condition FTGroup
REPEAT from to /note="Annexin #"

Additional information [?]

Size range 60-80 amino acids
Related rules None
Fusion None
Repeats 4-8
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]