ProRule PRU01245

General rule information [?]

Accession PRU01245
Dates 19-JUN-2019 (Created)
22-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51897; ANNEXIN_2
Name Annexin repeat
Function Annexins are a group of calcium-binding proteins that associate reversibly with membranes. Each of these proteins consist of a unique N- terminal domain followed by four or eight copies (in annexin A6) of a conserved segment of approximately 70 residues. Each of the repeats has the potential to have a type II Ca(2+)-binding bipartite motif, located on two different alpha-helices (GxGT-(38-40 residues)-D/E), but typically some of them are non-functional.
Scope(s) Eukaryota
Example(s) P09525 (ANXA4_HUMAN);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the annexin family.

Keywords [?]

Gene Ontology [?]

GO:0005509; Molecular function:calcium ion binding
GO:0005544; Molecular function:calcium-dependent phospholipid binding

Cross-references [?]

PROSITE PS00223; ANNEXIN_1; 4-8;

Features [?]

From: PS51897
Key From To Description Tag Condition FTGroup
REPEAT from to /note="Annexin #"

Additional information [?]

Size range 60-80 amino acids
Related rules None
Fusion None
Repeats 4-8
Topology Undefined


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UniProtKB rule member sequences [?]