Home  |  Contact
annotation rule: PRU01245

General rule information [?]

Accession PRU01245
Dates 19-JUN-2019 (Created)
19-JUN-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51897; ANNEXIN_2
Name Annexin repeat
Function Annexins are a group of calcium-binding proteins that associate reversibly with membranes. Each of these proteins consist of a unique N- terminal domain followed by four or eight copies (in annexin A6) of a conserved segment of approximately 70 residues. Each of the repeats has the potential to have a type II Ca(2+)-binding bipartite motif, located on two different alpha-helices (GxGT-(38-40 residues)-D/E), but typically some of them are non-functional.

Propagated annotation [?]


Cross-references [?]

PROSITE PS00223; ANNEXIN_1; 4-8;

Comments [?]

Similarity Belongs to the annexin family.

Gene Ontology [?]

GO:0005509; Molecular function: calcium ion binding.
GO:0005544; Molecular function: calcium-dependent phospholipid binding.

Keywords [?]


Features [?]

From: PS51897
Key     From     To       Description   Tag   Condition   FTGroup
REPEAT     from     to       Annexin #        

Additional information [?]

Size range 60-80 amino acids
Related rules None
Repeats 4-8
Topology Undefined
Example P09525 (ANXA4_HUMAN)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]