ProRule PRU01245
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01245 |
| Accession | PRU01245 |
| Dates | 19-JUN-2019 (Created)
22-NOV-2019 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51897; ANNEXIN_2 |
Name | Annexin repeat |
| Function | Annexins are a group of calcium-binding proteins that associate reversibly with membranes. Each of these proteins consist of a unique N- terminal domain followed by four or eight copies (in annexin A6) of a conserved segment of approximately 70 residues. Each of the repeats has the potential to have a type II Ca(2+)-binding bipartite motif, located on two different alpha-helices (GxGT-(38-40 residues)-D/E), but typically some of them are non-functional. |
| Scope(s) |
Eukaryota |
| Example(s) | P09525 (ANXA4_HUMAN); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the annexin family. |
Keywords
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Gene Ontology
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| GO:0005509; Molecular function:calcium ion binding |
| GO:0005544; Molecular function:calcium-dependent phospholipid binding |
Cross-references
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| PROSITE | PS00223; ANNEXIN_1; 4-8; |
Features
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| From: PS51897 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | from | to | /note="Annexin #" | |||||||||
Additional information
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| Size range | 60-80 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 4-8 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [103] All [ 103 ]
- Retrieve set of proteins with 3D structure for this domain