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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01249


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01249
General rule information [?]

Accession PRU01249
Dates 07-AUG-2019 (Created)
08-OCT-2024 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51901; ACP_MB
Name Archaeal CBS proteins (ACP)-type metal binding (MB) domain
Function An archaeal family of CBS domain (see ) proteins that are able to function as electron transfer proteins contains a small (~35 amino acids) C-terminal metal-binding (MB) domain containing four cysteine residues arranged in a Cys-X(2)-Cys-X(14-19)-Cys-X(1-4)-Cys motif. The ACP-type MB domain can bind several metals, with iron and zinc being the most abundant metals.
Scope(s) Archaea
Methanobacteriati
Example(s) P50100;

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
Metal-binding
Iron
Zinc
end case

Features [?]

From: PS51901
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ACP-type MB #"
BINDING 6 6 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 C 1
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 9 9 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 C 1
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 25 25 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 C 1
BINDING 25 25 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 28 28 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 C 1
BINDING 28 28 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1

Additional information [?]

Size range 25-40 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]