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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01253


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01253
General rule information [?]

Accession PRU01253
Dates 18-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51905; ZF_UBZ1
Name Zinc finger UBZ1-type
Function The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 1 UBZs are CCHH-type zinc fingers found in tandem UBZ domains of TAX1-binding protein 1 (TAX1BP1).
Scope(s) Eukaryota
Metazoa
Example(s) Q9V9Y9;

Propagated annotation [?]

Keywords [?]

Zinc-finger
case <Feature:PS51905:4=[CH]> and <Feature:PS51905:7=[CH]> and <Feature:PS51905:23=[CH]> and <Feature:PS51905:27=[CH]>
Zinc
Metal-binding
end case

Features [?]

From: PS51905
Key From To Description Tag Condition FTGroup
case <Feature:PS51905:4=C> and <Feature:PS51905:7=C> and <Feature:PS51905:23=H> and <Feature:PS51905:27=H>
ZN_FING from to /note="UBZ1-type #"
else case <Feature:PS51905:4=[CH]> and <Feature:PS51905:7=[CH]> and <Feature:PS51905:23=[CH]> and <Feature:PS51905:27=[CH]>
ZN_FING from to /note="UBZ1-type #; atypical"
else
ZN_FING from to /note="UBZ1-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 7 7 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 27 27 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 20-30 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]