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ProRule PRU01253


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01253
Accession PRU01253
Dates 18-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51905; ZF_UBZ1
Name Zinc finger UBZ1-type
Function The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 1 UBZs are CCHH-type zinc fingers found in tandem UBZ domains of TAX1-binding protein 1 (TAX1BP1).
Scope(s) Eukaryota
Metazoa
Example(s) Q9V9Y9 (SPNF_DROME);

Propagated annotation [?]

Keywords [?]

Zinc-finger
case <Feature:PS51905:4=[CH]> and <Feature:PS51905:7=[CH]> and <Feature:PS51905:23=[CH]> and <Feature:PS51905:27=[CH]>
Zinc
Metal-binding
end case

Features [?]

From: PS51905
Key From To Description Tag Condition FTGroup
case <Feature:PS51905:4=C> and <Feature:PS51905:7=C> and <Feature:PS51905:23=H> and <Feature:PS51905:27=H>
ZN_FING from to /note="UBZ1-type #"
else case <Feature:PS51905:4=[CH]> and <Feature:PS51905:7=[CH]> and <Feature:PS51905:23=[CH]> and <Feature:PS51905:27=[CH]>
ZN_FING from to /note="UBZ1-type #; atypical"
else
ZN_FING from to /note="UBZ1-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 7 7 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 27 27 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 20-30 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]