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PRU01255


General rule information [?]

Accession PRU01255
Dates 19-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS51907; ZF_UBZ3
Name Zinc finger UBZ3-type
Function The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the DNA polymerase type-Y family.

Gene Ontology [?]

GO:0042276; Biological process: error-prone translesion synthesis.
GO:0035861; Cellular component: site of double-strand break.
GO:0009314; Biological process: response to radiation.
case <Feature:PS51907:8=[CH]> and <Feature:PS51907:11=[CH]> and <Feature:PS51907:23=[CH]> and <Feature:PS51907:27=[CH]>
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Metal-binding
Zinc
end case

Zinc-finger
DNA damage
DNA repair

Features [?]

case <Feature:PS51907:8=C> and <Feature:PS51907:11=C> and <Feature:PS51907:23=H> and <Feature:PS51907:27=H>
From: PS51907
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     from     to       UBZ3-type #        
else case <Feature:PS51907:8=[CH]> and <Feature:PS51907:11=[CH]> and <Feature:PS51907:23=[CH]> and <Feature:PS51907:27=[CH]>
ZN_FING     from     to       UBZ3-type #; atypical        
else
ZN_FING     from     to       UBZ3-type #; degenerate        
end case

BINDING     8     8       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     11     11       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     23     23       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     27     27       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1

Additional information [?]

Size range 30-40 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9Y253 (POLH_HUMAN)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]