ProRule PRU01255

PURL	https://purl.expasy.org/prosite/rule/PRU01255
Accession	PRU01255
Dates	19-SEP-2019 (Created) 19-NOV-2022 (Last updated, Version 8)
Data class	Domain;
Predictors	PROSITE; PS51907; ZF_UBZ3
Name	Zinc finger UBZ3-type
Function	The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta.
Scope(s)	Eukaryota
Example(s)	Q9Y253 (POLH_HUMAN);

From: PS51907
Key	From	To	Description	Tag	Condition	FTGroup
case <Feature:PS51907:8=C> and <Feature:PS51907:11=C> and <Feature:PS51907:23=H> and <Feature:PS51907:27=H>
ZN_FING	from	to	/note="UBZ3-type #"
else case <Feature:PS51907:8=[CH]> and <Feature:PS51907:11=[CH]> and <Feature:PS51907:23=[CH]> and <Feature:PS51907:27=[CH]>
ZN_FING	from	to	/note="UBZ3-type #; atypical"
else
ZN_FING	from	to	/note="UBZ3-type #; degenerate"
end case
BINDING	8	8	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	11	11	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	23	23	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	27	27	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1