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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01255


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01255
General rule information [?]

Accession PRU01255
Dates 19-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51907; ZF_UBZ3
Name Zinc finger UBZ3-type
Function The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta.
Scope(s) Eukaryota
Example(s) Q9Y253;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the DNA polymerase type-Y family.

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger
DNA damage
DNA repair

Gene Ontology [?]

GO:0042276; Biological process:error-prone translesion synthesis
GO:0035861; Cellular component:site of double-strand break
GO:0009314; Biological process:response to radiation
case <Feature:PS51907:8=[CH]> and <Feature:PS51907:11=[CH]> and <Feature:PS51907:23=[CH]> and <Feature:PS51907:27=[CH]>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51907
Key From To Description Tag Condition FTGroup
case <Feature:PS51907:8=C> and <Feature:PS51907:11=C> and <Feature:PS51907:23=H> and <Feature:PS51907:27=H>
ZN_FING from to /note="UBZ3-type #"
else case <Feature:PS51907:8=[CH]> and <Feature:PS51907:11=[CH]> and <Feature:PS51907:23=[CH]> and <Feature:PS51907:27=[CH]>
ZN_FING from to /note="UBZ3-type #; atypical"
else
ZN_FING from to /note="UBZ3-type #; degenerate"
end case
BINDING 8 8 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 11 11 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 27 27 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 30-40 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]