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ProRule PRU01255


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PURL: https://purl.expasy.org/prosite/rule/PRU01255
General rule information [?]

Accession PRU01255
Dates 19-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51907; ZF_UBZ3
Name Zinc finger UBZ3-type
Function The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta.
Scope(s) Eukaryota
Example(s) Q9Y253;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the DNA polymerase type-Y family.

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger
DNA damage
DNA repair

Gene Ontology [?]

GO:0042276; Biological process:error-prone translesion synthesis
GO:0035861; Cellular component:site of double-strand break
GO:0009314; Biological process:response to radiation
case <Feature:PS51907:8=[CH]> and <Feature:PS51907:11=[CH]> and <Feature:PS51907:23=[CH]> and <Feature:PS51907:27=[CH]>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51907
Key From To Description Tag Condition FTGroup
case <Feature:PS51907:8=C> and <Feature:PS51907:11=C> and <Feature:PS51907:23=H> and <Feature:PS51907:27=H>
ZN_FING from to /note="UBZ3-type #"
else case <Feature:PS51907:8=[CH]> and <Feature:PS51907:11=[CH]> and <Feature:PS51907:23=[CH]> and <Feature:PS51907:27=[CH]>
ZN_FING from to /note="UBZ3-type #; atypical"
else
ZN_FING from to /note="UBZ3-type #; degenerate"
end case
BINDING 8 8 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 11 11 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 27 27 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 30-40 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]