ProRule PRU01255
General rule information
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| Accession | PRU01255 |
| Dates | 19-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51907; ZF_UBZ3 |
Name | Zinc finger UBZ3-type |
| Function | The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta. |
| Scope(s) |
Eukaryota |
| Example(s) | Q9Y253 (POLH_HUMAN); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the DNA polymerase type-Y family. |
Keywords
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| Metal-binding | |
| Zinc | |
| end case | |
| Zinc-finger | |
| DNA damage | |
| DNA repair | |
Gene Ontology
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| GO:0042276; Biological process:error-prone translesion synthesis | |
| GO:0035861; Cellular component:site of double-strand break | |
| GO:0009314; Biological process:response to radiation | |
| case <Feature:PS51907:8=[CH]> and <Feature:PS51907:11=[CH]> and <Feature:PS51907:23=[CH]> and <Feature:PS51907:27=[CH]> | |
| GO:0046872; Molecular function:metal ion binding | |
Features
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| From: PS51907 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <Feature:PS51907:8=C> and <Feature:PS51907:11=C> and <Feature:PS51907:23=H> and <Feature:PS51907:27=H> | ||||||||||||
| ZN_FING | from | to | /note="UBZ3-type #" | |||||||||
| else case <Feature:PS51907:8=[CH]> and <Feature:PS51907:11=[CH]> and <Feature:PS51907:23=[CH]> and <Feature:PS51907:27=[CH]> | ||||||||||||
| ZN_FING | from | to | /note="UBZ3-type #; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | from | to | /note="UBZ3-type #; degenerate" | |||||||||
| end case | ||||||||||||
| BINDING | 8 | 8 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 11 | 11 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 23 | 23 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 27 | 27 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
Additional information
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| Size range | 30-40 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [6] All [ 6 ]
- Retrieve set of proteins with 3D structure for this domain