ProRule PRU01256

General rule information [?]

Accession PRU01256
Dates 19-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51908; ZF_UBZ4
Name Zinc finger UBZ4-type
Function The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 4 UBZs are CCHC-type zinc fingers found in Y-family translesion polymerase kappa, Werner helicase- interacting protein 1 (WRNIP1), and Rad18.
Scope(s) Eukaryota
Example(s) Q9UBT6 (POLK_HUMAN);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

case <Feature:PS51908:4=[CH]> and <Feature:PS51908:7=[CH]> and <Feature:PS51908:19=[CH]> and <Feature:PS51908:23=[CH]>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51908
Key From To Description Tag Condition FTGroup
case <Feature:PS51908:4=C> and <Feature:PS51908:7=C> and <Feature:PS51908:19=H> and <Feature:PS51908:23=C>
ZN_FING from to /note="UBZ4-type #"
else case <Feature:PS51908:4=[CH]> and <Feature:PS51908:7=[CH]> and <Feature:PS51908:19=[CH]> and <Feature:PS51908:23=[CH]>
ZN_FING from to /note="UBZ4-type #; atypical"
ZN_FING from to /note="UBZ4-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
[CH] 1
BINDING 7 7 /ligand="Zn(2+)"
[CH] 1
BINDING 19 19 /ligand="Zn(2+)"
[CH] 1
BINDING 23 23 /ligand="Zn(2+)"
[CH] 1

Additional information [?]

Size range 20-35 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]