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PRU01256


General rule information [?]

Accession PRU01256
Dates 19-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51908; ZF_UBZ4
Name Zinc finger UBZ4-type
Function The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 4 UBZs are CCHC-type zinc fingers found in Y-family translesion polymerase kappa, Werner helicase- interacting protein 1 (WRNIP1), and Rad18.

Propagated annotation [?]


Gene Ontology [?]

case <Feature:PS51908:4=[CH]> and <Feature:PS51908:7=[CH]> and <Feature:PS51908:19=[CH]> and <Feature:PS51908:23=[CH]>
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Metal-binding
Zinc
end case

Zinc-finger
DNA damage
DNA repair

Features [?]

case <Feature:PS51908:4=C> and <Feature:PS51908:7=C> and <Feature:PS51908:19=H> and <Feature:PS51908:23=C>
From: PS51908
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     from     to       UBZ4-type #        
else case <Feature:PS51908:4=[CH]> and <Feature:PS51908:7=[CH]> and <Feature:PS51908:19=[CH]> and <Feature:PS51908:23=[CH]>
ZN_FING     from     to       UBZ4-type #; atypical        
else
ZN_FING     from     to       UBZ4-type #; degenerate        
end case

BINDING     4     4       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     7     7       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     19     19       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     23     23       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1

Additional information [?]

Size range 20-35 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example Q9UBT6 (POLK_HUMAN)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]