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PROSITE entry PS51908


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General information about the entry

Entry name [info] ZF_UBZ4
Accession [info] PS51908
Entry type [info] MATRIX
Date [info] 13-NOV-2019 CREATED;
07-APR-2021 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51905
Associated ProRule [info] PRU01256

Name and characterization of the entry

Description [info] Zinc finger UBZ4-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=28;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=26;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5569990; R2=0.0071366; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2649.1757812; R2=0.5597523; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1184; H_SCORE=3312; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=553; H_SCORE=2959; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-34; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='K';  M= -24, -84,  12, -66, -72,  -5,  14,   1,  41,  32,  30, -68, -81,  35, -14, -32,   7, -15,  16, -69;
/M: SY='V';  M= -10, -80, -88, -82,  17,  -4, -86,   1,   1,  21, -55, -82,   1, -80, -25, -75, -67,  73, -86, -68;
/M: SY='Q';  M=  22, -14,  -4,   3,   5, -76,   5,   2, -30, -41, -68,  -6,  35,  52, -71,  17,   2, -20, -81,  26;
/M: SY='C';  M= -72, 156, -92, -92, -82, -87, -92, -89, -87, -80, -80, -78,-103, -95, -94, -74, -72, -76,-112, -93;
/M: SY='P';  M= -75,-101, -76, -64, -96, -78, -78, -84, -72, -94, -80, -81, 126,  13, -83, -22, -69, -89, -89, -92;
/M: SY='I';  M= -45, -81, -89, -86, -62, -91, -87,  68, -84,  21,   9, -22, -86, -81, -86,   2, -15,  61, -90, -69;
/M: SY='C';  M= -72, 156, -92, -92, -82, -87, -92, -89, -87, -80, -80, -78,-103, -95, -94, -74, -72, -76,-112, -93;
/M: SY='Q';  M=  -9, -85, -10, -20,   6,  42,  10, -83, -64, -22, -73,  48, -80,  79, -68,  18, -67, -82, -86, -72;
/M: SY='K';  M= -41, -86, -37,  19, -82, -39, -69,  -2,  55, -46,  37, -13, -77,  54,  32, -65,  29, -12, -87, -74;
/M: SY='M';  M= -42, -16,   7,  26, -27, -41, -12, -71,  14,  -8,  57,  41,  38, -63,  18, -22,   5, -16, -90, -74;
/M: SY='F';  M= -74, -82, -92, -84,  69, -92, -77,  16, -81,  19,  68, -85, -89,  25, -81, -80, -70,  48, -72,  11;
/M: SY='P';  M= -67, -86, -68,  30, -10, -42, -73, -78,  11, -14,  -7, -21,  79, -64, -29,  54, -11, -51, -88, -77;
/M: SY='E';  M=  14,  -9, -67,  37, -27, -10,  22, -37, -30,  17,  13,  16,  18, -64,  14,   4,  16, -70, -89, -73;
/M: SY='S';  M=  16, -80,  -3,  12, -70, -75, -68, -35, -31,  16,  28,  25, -79, -13,  -6,  33,  32, -38, -83,  31;
/M: SY='D';  M=   0, -83,  43,  -5, -26, -77,  38, -31,  33,  12, -67,  10, -79,  33, -64,  18, -23, -14, -89, -20;
/M: SY='I';  M= -72, -83, -26, -86, -57,  -7, -81,  66, -85,  43, -49, -83, -88, -81, -86, -13, -69,  34, -79,  35;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='N';  M= -73, -84, -18,  36,  -8, -21,  -2,  -7,  -3, -83, -76,  92, -79, -14,  33, -61,  -5, -80, -93, -75;
/M: SY='W';  M= -67,   3, -33,  15, -81, -39, -71, -15,   7, -80, -74, -65,  -5,  58,  38,  42,  20, -20,  74, -71;
/M: SY='H';  M= -80, -92, -64, -64, -78, -82, 151, -97, -69, -79, -64, -53, -80, -58, -63, -69, -78, -96,-114, -47;
/M: SY='L';  M=  -5,  10, -93, -86, -58, -92, -83,  15, -86,  65,  38, -89, -90, -82, -85, -80, -69,  52, -87, -68;
/M: SY='D';  M= -37, -87, 105, -49,  -4, -74, -63, -86,  -9, -84,  35,  48, -79, -65, -71, -65, -67, -86,-102, -75;
/I:         I=-30; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='E';  M= -69, -86,  -1,  49, -71, -80, -67,   8, -37, -44, -22, -25, -78,  22,  30,  34,  13,  -8,  25,  45;
/M: SY='C';  M= -72, 154, -90, -90, -82, -87,  12, -89, -87, -79, -79, -77,-101, -93, -92, -74, -72, -77,-112, -90;
/M: SY='L';  M=   9, -80, -81, -79, -60, -42, -74,   0, -19,  69, -50,  30, -23, -21, -78, -73,   2, -56, -82,   2;
/M: SY='D';  M= -67, -83,  55,  -5, -84,  34, -70, -74, -32, -25,  -8,  53, -80, -25, -75,  22,   5,  15, -97, -80;
/M: SY='K';  M=  -6, -84,   5,   9, -30,  24, -72, -78,  26,   4,  -7,  21, -80, -65,  19,  22,   6, -40, -90, -77;
/M: SY='P';  M=  -3, -89,  41,  -4, -85,  20,  -5, -79,   3, -48,  56, -35,  57, -17, -25,   2, -70, -34, -91, -27;
/M: SY='S';  M= -22, -86,  11,  44, -16, -17, -73, -41, -29, -83, -78, -11,  39,  12, -73,  48,  18, -13, -92, -79;
/I:         E1=0; IE=-255; DE=-255;
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Post-processing [info]

COMPETES_HIT_WITH PS50157; PS51801; PS51905; PS51906; PS51907

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 53 in 48 different sequences
Number of true positive hits 53 in 48 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 1
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 98.15 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] ZN_FING
Feature description [info] UBZ4-type
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
48 sequences

DCR1A_CHICK (Q5QJC4), DCR1A_HUMAN (Q6PJP8), DCR1A_MOUSE (Q9JIC3), 
FAN1_AILME  (D2HNY3), FAN1_CAEBR  (A8WZU5), FAN1_CAEEL  (P90740), 
FAN1_DANRE  (Q1LWH4), FAN1_HUMAN  (Q9Y2M0), FAN1_MOUSE  (Q69ZT1), 
FAN1_ORYSJ  (Q5SNL7), POLK_CAEEL  (P34409), POLK_HUMAN  (Q9UBT6), 
POLK_MOUSE  (Q9QUG2), POLK_SCHPO  (O74944), PSO2_SCHPO  (Q10264), 
PSO2_YEAST  (P30620), RAD18_ASPFU (Q4WZJ6), RAD18_CANAL (Q5A4N5), 
RAD18_CANGA (Q6FPI4), RAD18_DEBHA (Q6BLM3), RAD18_EMENI (Q02398), 
RAD18_EREGS (Q75EN0), RAD18_HUMAN (Q9NS91), RAD18_KLULA (Q6CTZ8), 
RAD18_MOUSE (Q9QXK2), RAD18_NEUCR (P33288), RAD18_SCHPO (O74747), 
RAD18_YARLI (Q6CHI1), RAD18_YEAST (P10862), SLX4_HUMAN  (Q8IY92), 
SLX4_MOUSE  (Q6P1D7), SPRTN_BOVIN (A5D979), SPRTN_CAEEL (Q22557), 
SPRTN_DANRE (A0A0G2L7I0), SPRTN_HUMAN (Q9H040), SPRTN_MOUSE (G3X912), 
SPRTN_RAT   (D3ZVU1), SPRTN_XENLA (A0A1L8G2K9), SPRTN_XENTR (F6UH96), 
UIMC1_HUMAN (Q96RL1), UIMC1_MOUSE (Q5U5Q9), UIMC1_PIG   (A0P8Z5), 
UIMC1_RAT   (Q5PQK4), WRIP1_HUMAN (Q96S55), WRIP1_MOUSE (Q91XU0), 
WRIP1_RAT   (Q8CG07), WRIP1_SCHPO (O13984), WRIP1_YEAST (P40151)
» more

UniProtKB/Swiss-Prot
False negative sequences
1 sequence

NCAA_ASPFU  (Q4WN10)

		
PDB
[Detailed view]
7 PDB

2MRE; 2MRF; 3VHS; 3VHT; 5VF0; 7NV0; 7NV1