PROSITE entry PS51906

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General information about the entry

Entry name [info]	ZF_UBZ2
Accession [info]	PS51906
Entry type [info]	MATRIX
Date [info]	13-NOV-2019 CREATED; 07-APR-2021 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51905
Associated ProRule [info]	PRU01254

Name and characterization of the entry

Description [info]

Zinc finger UBZ2-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=37;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=34;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.0545666; R2=0.0077926; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3947.9506836; R2=0.6822177; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=956; H_SCORE=4600; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=443; H_SCORE=4250; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-45; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='L';  M= -74, -78, -90, -83, -54, -93, -79, -43, -24,  71,  -4, -87, -90, -78, -80, -81,  -3,   4, -84, -65;
/M: SY='Q';  M= -20, -88,  14,   8, -89, -77, -31, -82, -52, -44, -71, -28, -77,  81,  33, -12,  -2, -48, -88, -74;
/M: SY='S';  M= -15,  50, -70, -68, -81, -42, -57, -79, -68, -24, -74, -48, -78,  19, -48,  77,  -6, -73, -92, -76;
/M: SY='C';  M= -71, 144, -91, -91, -81, -87, -91, -88, -87, -79, -79, -77,-102, -95, -93, -74, -71, -76,-111, -92;
/M: SY='P';  M= -76,-102, -77, -65, -96, -78, -80, -84, -73, -94, -80, -83, 118, -76, -85, -74, -69, -89, -89, -93;
/M: SY='M';  M= -72, -80, -94, -85, -59, -88, -68,  15, -79,  13, 123, -82, -83, -71, -77, -82, -70, -49, -83, -61;
/M: SY='C';  M= -71, 144, -91, -91, -81, -87, -91, -88, -87, -79, -79, -77,-102, -95, -93, -74, -71, -76,-111, -92;
/M: SY='Q';  M= -48,  -1, -74, -58, -74, -33, -66, -65, -62,  39, -55, -70, -83,  96, -62, -67, -72, -69, -82, -69;
/M: SY='K';  M=  23, -80, -75, -19, -73, -79,   0, -12,  31,   4,  28, -71, -79,  24, -63, -66, -10,  12, -87, -71;
/M: SY='D';  M=   4, -83,  41,  39, -83, -77, -70, -70, -27, -25, -71, -26, -17,  18, -44, -23,  -2,  10, -93, -77;
/M: SY='F';  M= -83, -79, -95, -91, 112, -91, -75, -55, -86, -16, -57, -85, -94, -96, -83, -82, -75, -61, -49, -28;
/M: SY='P';  M=  38, -79, -14,  27, -81, -16, -41, -73, -63, -28, -69, -65,  73, -61, -59,   0,   6, -56, -84, -77;
/M: SY='P';  M=   1, -81, -51, -43, -80, -15, -72, -70, -44, -33, -69, -66,  89, -65, -19,  33,   1, -15, -84, -78;
/M: SY='G';  M= -58, -79, -64, -36, -82,  62,  30, -85, -14, -82,  -8,  -4,   2, -59,  29,  31, -13, -80, -83, -73;
/I:         I=-4; MD=-9;
/M: SY='L';  M= -70, -75, -86, -77,  59, -84, -71, -43, -77,  60,  24, -80, -85,   4, -75, -16, -66,  -6,  49, -30; D=-4;
/I:         I=-4; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='T';  M=  36, -68,  -3, -62, -70, -61, -65, -68, -62, -71, -19, -53, -67, -60, -68,  57,  67, -61, -81,  14; D=-4;
/I:         I=-4; DM=-9;
/M: SY='Q';  M= -64, -89, -61, -41, -90, -71, -54, -77, -47, -65,   4, -57,  47, 118, -48, -55, -65, -79, -77, -67; D=-4;
/I:         I=-4; DM=-9;
/M: SY='M';  M= -68, -73, -88, -79, -47, -86, -68,  17, -77,  68,  94, -81, -82, -70, -75, -78, -65, -41, -75, -56;
/M: SY='D';  M= -65, -80, 109,  43, -87, -65, -53, -85, -52, -83, -81, -38, -64, -50, -61,  -9, -57, -81, -97, -71;
/M: SY='I';  M= -62,  52, -76, -70, -58, -83, -74,  74, -16, -45, -28, -68, -75, -14,  46, -66, -14,  37, -79, -61;
/M: SY='D';  M= -67, -81, 117,   7, -88, -65, -53, -86, -54, -84, -83, -36, -66, -53, -63, -56, -57, -83,-102, -71;
/M: SY='S';  M= -13, -69, -59, -63, -77,  62, -63, -78, -59, -79, -71, -21, -66, -55, -12,  82, -47, -54, -79, -70;
/M: SY='H';  M= -69, -81, -53, -53, -68, -71, 149, -86, -58, -68, -54, -43, -70, -47, -52, -59, -68, -86,-103, -37;
/M: SY='L';  M= -67, -70, -85, -78, -42, -87, -71,  41, -78,  84, -29, -82, -82, -71, -76, -77, -62, -35, -71, -54;
/M: SY='A';  M=  99, -61, -68, -60, -76, -49, -69, -65, -63, -67, -61, -62, -66, -59, -67, -41, -52, -52, -76, -71;
/M: SY='Q';  M=   1, -79, -55,  -2, -82, -66, -52, -71,  12, -70, -60,  -8, -67, 106,  33,  -3, -58, -18, -75, -63;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='L';  M= -67, -69, -85, -77, -40, -86, -68, -32, -78,  92, -28, -84, -84, -71, -75, -77, -63, -39, -71, -53;
/M: SY='S';  M=  67, -63, -60, -33, -75, -49, -63, -70, -59, -72, -66, -52, -65, -53, -64,  82, -43, -59, -79, -69;
/M: SY='E';  M=  -3, -77,  21,  90, -79,  18, -57, -78, -48, -22, -68, -54, -60,  -3, -57,  -8, -59, -72, -80, -71;
/I:         I=-30; MD=-77;
/M: SY='S';  M=  -9, -28, -64, -63, -68, -59, -62, -58, -60, -46,  74,  -7, -69, -55, -21,  81,  -3,   0, -83, -64; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='T';  M=  24, -65,  20,  -6, -73, -60, -59, -40, -54, -69, -64,  56, -64, -55, -23,   4,  80, -59, -87, -68;
/M: SY='D';  M= -48, -76,  77,  63, -74, -14, -58, -61, -54, -50,  46, -50, -65, -50, -62, -57, -22,  23, -87, -68;
/M: SY='D';  M= -67, -81, 117,   9, -88, -65, -53, -86, -54, -84, -83, -36, -66, -53, -63, -56, -57, -83,-102, -71;
/M: SY='V';  M= -16, -68, -82, -76, -54, -30, -75,  20, -72, -23,  81, -74, -76, -71, -73, -66, -54,  82, -82, -59;
/M: SY='M';  M= -35, -69,   1, -17, -61, -44, -69,  -8, -62, -49,  61, -61, -69,  25, -66, -54,  60,  57,  43, -60;
/M: SY='W';  M= -76,  33,-102, -82, -45, -76,-103, -76, -74, -73, -76, -94, -82, -75, -78, -82, -39, -88, 173, -32;
/I:         E1=0; IE=-255; DE=-255;

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Post-processing [info]

COMPETES_HIT_WITH

PS50157; PS51801; PS51905; PS51907; PS51908

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	4 in 4 different sequences
Number of true positive hits	4 in 4 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Feature key [info]	ZN_FING
Feature description [info]	UBZ2-type
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

4 sequences

FAP20_BOVIN (A5PKK9), FAP20_HUMAN (Q6NZ36), FAP20_MOUSE (Q3UN58),

FAP20_RAT   (D4AAA5)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

3 PDB

2MUQ; 2MUR; 3WWQ