PRU01254
General rule information
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Accession | PRU01254 |
Dates | 18-SEP-2019 (Created) 19-NOV-2022 (Last updated, Version 5) |
Data class | Domain |
Predictors | PROSITE; PS51906; ZF_UBZ2 |
Name | Zinc finger UBZ2-type |
Function | The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex. |
Propagated annotation
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Comments
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Domain | The UBZ2-type zinc finger binds both 'Lys-48'-and 'Lys-63'-linked polyubiquitin with preference for 'Lys-63'-linked polyubiquitin. |
Gene Ontology
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GO:0043130; Molecular function: ubiquitin binding.
GO:0043240; Cellular component: Fanconi anaemia nuclear complex.
GO:0043240; Cellular component: Fanconi anaemia nuclear complex.
case <Feature:PS51906:4=[CH]> and <Feature:PS51906:7=[CH]> and <Feature:PS51906:23=[CH]> and <Feature:PS51906:27=[CH]>
GO:0046872; Molecular function: metal ion binding.
Keywords
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end case
Features
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case <Feature:PS51906:4=C> and <Feature:PS51906:7=C> and <Feature:PS51906:23=H> and <Feature:PS51906:27=C>
From: PS51906 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ZN_FING | from | to | UBZ2-type # |
else case <Feature:PS51906:4=[CH]> and <Feature:PS51906:7=[CH]> and <Feature:PS51906:23=[CH]> and <Feature:PS51906:27=[CH]>
else
end case
Additional information
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Size range | 35-40 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q6NZ36 (FAP20_HUMAN) |
Scope | Eukaryota; Eutheria |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Eukaryota [4]
- Retrieve set of proteins with 3D structure for this domain