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PRU01254


General rule information [?]

Accession PRU01254
Dates 18-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51906; ZF_UBZ2
Name Zinc finger UBZ2-type
Function The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex.

Propagated annotation [?]


Comments [?]

Domain The UBZ2-type zinc finger binds both 'Lys-48'-and 'Lys-63'-linked polyubiquitin with preference for 'Lys-63'-linked polyubiquitin.

Gene Ontology [?]

GO:0043130; Molecular function: ubiquitin binding.
GO:0043240; Cellular component: Fanconi anaemia nuclear complex.
case <Feature:PS51906:4=[CH]> and <Feature:PS51906:7=[CH]> and <Feature:PS51906:23=[CH]> and <Feature:PS51906:27=[CH]>
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Metal-binding
Zinc
end case

Zinc-finger

Features [?]

case <Feature:PS51906:4=C> and <Feature:PS51906:7=C> and <Feature:PS51906:23=H> and <Feature:PS51906:27=C>
From: PS51906
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     from     to       UBZ2-type #        
else case <Feature:PS51906:4=[CH]> and <Feature:PS51906:7=[CH]> and <Feature:PS51906:23=[CH]> and <Feature:PS51906:27=[CH]>
ZN_FING     from     to       UBZ2-type #; atypical        
else
ZN_FING     from     to       UBZ2-type #; degenerate        
end case

BINDING     4     4       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     7     7       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     23     23       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     27     27       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1

Additional information [?]

Size range 35-40 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q6NZ36 (FAP20_HUMAN)
Scope
Eukaryota; Eutheria
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]