ProRule PRU01254

General rule information [?]

Accession PRU01254
Dates 18-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51906; ZF_UBZ2
Name Zinc finger UBZ2-type
Function The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex.
Scope(s) Eukaryota
Example(s) Q6NZ36 (FAP20_HUMAN);

Propagated annotation [?]

Comments [?]

DOMAINThe UBZ2-type zinc finger binds both 'Lys-48'-and 'Lys-63'- linked polyubiquitin with preference for 'Lys-63'-linked polyubiquitin.

Keywords [?]

Gene Ontology [?]

GO:0043130; Molecular function:ubiquitin binding
GO:0043240; Cellular component:Fanconi anaemia nuclear complex
case <Feature:PS51906:4=[CH]> and <Feature:PS51906:7=[CH]> and <Feature:PS51906:23=[CH]> and <Feature:PS51906:27=[CH]>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51906
Key From To Description Tag Condition FTGroup
case <Feature:PS51906:4=C> and <Feature:PS51906:7=C> and <Feature:PS51906:23=H> and <Feature:PS51906:27=C>
ZN_FING from to /note="UBZ2-type #"
else case <Feature:PS51906:4=[CH]> and <Feature:PS51906:7=[CH]> and <Feature:PS51906:23=[CH]> and <Feature:PS51906:27=[CH]>
ZN_FING from to /note="UBZ2-type #; atypical"
ZN_FING from to /note="UBZ2-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
[CH] 1
BINDING 7 7 /ligand="Zn(2+)"
[CH] 1
BINDING 23 23 /ligand="Zn(2+)"
[CH] 1
BINDING 27 27 /ligand="Zn(2+)"
[CH] 1

Additional information [?]

Size range 35-40 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]