ProRule PRU01254

Accession	PRU01254
Dates	18-SEP-2019 (Created) 19-NOV-2022 (Last updated, Version 5)
Data class	Domain;
Predictors	PROSITE; PS51906; ZF_UBZ2
Name	Zinc finger UBZ2-type
Function	The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex.
Scope(s)	Eukaryota Eutheria
Example(s)	Q6NZ36 (FAP20_HUMAN);

From: PS51906
Key	From	To	Description	Tag	Condition	FTGroup
case <Feature:PS51906:4=C> and <Feature:PS51906:7=C> and <Feature:PS51906:23=H> and <Feature:PS51906:27=C>
ZN_FING	from	to	/note="UBZ2-type #"
else case <Feature:PS51906:4=[CH]> and <Feature:PS51906:7=[CH]> and <Feature:PS51906:23=[CH]> and <Feature:PS51906:27=[CH]>
ZN_FING	from	to	/note="UBZ2-type #; atypical"
else
ZN_FING	from	to	/note="UBZ2-type #; degenerate"
end case
BINDING	4	4	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	7	7	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	23	23	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	27	27	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1