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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01254


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01254
General rule information [?]

Accession PRU01254
Dates 18-SEP-2019 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51906; ZF_UBZ2
Name Zinc finger UBZ2-type
Function The ubiquitin-binding zinc finger (UBZ) is a type of zinc- coordinating beta-beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families. Type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex.
Scope(s) Eukaryota
Eutheria
Example(s) Q6NZ36;

Propagated annotation [?]

Comments [?]

DOMAINThe UBZ2-type zinc finger binds both 'Lys-48'-and 'Lys-63'- linked polyubiquitin with preference for 'Lys-63'-linked polyubiquitin.

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

GO:0043130; Molecular function:ubiquitin binding
GO:0043240; Cellular component:Fanconi anaemia nuclear complex
case <Feature:PS51906:4=[CH]> and <Feature:PS51906:7=[CH]> and <Feature:PS51906:23=[CH]> and <Feature:PS51906:27=[CH]>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51906
Key From To Description Tag Condition FTGroup
case <Feature:PS51906:4=C> and <Feature:PS51906:7=C> and <Feature:PS51906:23=H> and <Feature:PS51906:27=C>
ZN_FING from to /note="UBZ2-type #"
else case <Feature:PS51906:4=[CH]> and <Feature:PS51906:7=[CH]> and <Feature:PS51906:23=[CH]> and <Feature:PS51906:27=[CH]>
ZN_FING from to /note="UBZ2-type #; atypical"
else
ZN_FING from to /note="UBZ2-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 7 7 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 27 27 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 35-40 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]