ProRule PRU01257

General rule information [?]

Accession PRU01257
Dates 3-OCT-2019 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51909; LYSOZYME_I
Name Invertebrate (I)-type lysozyme domain
Function I-type lysozymes have been identified in phylogenetically diverse organisms, including mollusca, nematoda, annelida, arthropoda and echinodermata. I-type lysozymes play an important role in immunity and digestion in invertebrates and are usually regarded as the first barrier against pathogens. I-type lysozymes exert multiple activities, such as muramidase, isopeptidase, chitinase, and non-enzymatic antibacterial activities.
Scope(s) Eukaryota
Example(s) Q8IU26 (LYS_RUDPH);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=;

Comments [?]

CATALYTIC ACTIVITY Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=;
end case
SIMILARITYBelongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily.
case <FTGroup:1>

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0003824; Molecular function:catalytic activity
GO:0019835; Biological process:cytolysis
GO:0042742; Biological process:defense response to bacterium
GO:0016798; Molecular function:hydrolase activity, acting on glycosyl bonds
GO:0008152; Biological process:metabolic process
GO:0016787; Molecular function:hydrolase activity

Features [?]

From: PS51909
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="I-type lysozyme #"
ACT_SITE 16 16 /note="Proton donor" E 1
ACT_SITE 26 26 /note="Nucleophile" D 1
DISULFID 8 91 disulf C-x*-C
DISULFID 11 123 disulf C-x*-C
DISULFID 13 19 disulf C-x*-C
DISULFID 23 32 disulf C-x*-C
DISULFID 45 73 disulf C-x*-C
DISULFID 63 69 disulf C-x*-C
DISULFID 87 105 disulf C-x*-C

Additional information [?]

Size range 110-130 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]