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annotation rule: PRU01257

General rule information [?]

Accession PRU01257
Dates 3-OCT-2019 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51909; LYSOZYME_I
Name Invertebrate (I)-type lysozyme domain
Function I-type lysozymes have been identified in phylogenetically diverse organisms, including mollusca, nematoda, annelida, arthropoda and echinodermata. I-type lysozymes play an important role in immunity and digestion in invertebrates and are usually regarded as the first barrier against pathogens. I-type lysozymes exert multiple activities, such as muramidase, isopeptidase, chitinase, and non-enzymatic antibacterial activities.

Propagated annotation [?]

Description [?]

case <FTGroup:1>
+ RecName: EC;

Comments [?]

Catalytic activity Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=;
end case

Similarity Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily.

Gene Ontology [?]

case <FTGroup:1>
GO:0003824; Molecular function: catalytic activity.
GO:0019835; Biological process: cytolysis.
GO:0042742; Biological process: defense response to bacterium.
GO:0016798; Molecular function: hydrolase activity, acting on glycosyl bonds.
GO:0008152; Biological process: metabolic process.
GO:0016787; Molecular function: hydrolase activity.

Keywords [?]

end case

case <FTTag:disulf>
end case

Features [?]

From: PS51909
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       I-type lysozyme #        
ACT_SITE     16     16       Proton donor     E   1
ACT_SITE     26     26       Nucleophile     D   1
DISULFID     8     91           disulf   C-x*-C  
DISULFID     11     123           disulf   C-x*-C  
DISULFID     13     19           disulf   C-x*-C  
DISULFID     23     32           disulf   C-x*-C  
DISULFID     45     73           disulf   C-x*-C  
DISULFID     63     69           disulf   C-x*-C  
DISULFID     87     105           disulf   C-x*-C  

Additional information [?]

Size range 110-130 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q8IU26 (LYS_RUDPH)
Eukaryota; Metazoa
Comments None


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UniProtKB rule member sequences [?]