ProRule PRU01270
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PURL: https://purl.expasy.org/prosite/rule/PRU01270
General rule information
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| Accession | PRU01270 |
| Dates | 31-MAR-2020 (Created)
30-SEP-2022 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51922; BCOV_S1_NTD |
Name | Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain |
| Function | The receptor binding domain (RBD) of betaCoV that directly engages the receptor is commonly located in the C-terminal half of S1 [C-terminal domain (CTD)] such as in SARS-CoV, SARS-CoV-2, MERS-CoV,and BatCoV HKU4, though in rare cases such as with mouse hepatitis virus (MHV), the RBD region was identified in the S1 N-terminal domain (NTD). |
| Scope(s) |
Viruses Betacoronavirus |
| Example(s) | P25194 (SPIKE_CVBV); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the betacoronaviruses spike protein family. |
Keywords
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Gene Ontology
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| GO:0016020; Cellular component:membrane |
| GO:0019064; Biological process:fusion of virus membrane with host plasma membrane |
| GO:0044173; Cellular component:host cell endoplasmic reticulum-Golgi intermediate compartment membrane |
| GO:0075509; Biological process:endocytosis involved in viral entry into host cell |
| GO:0055036; Cellular component:virion membrane |
| GO:0046813; Biological process:receptor-mediated virion attachment to host cell |
| GO:0019031; Cellular component:viral envelope |
| GO:0039654; Biological process:fusion of virus membrane with host endosome membrane |
| GO:0020002; Cellular component:host cell plasma membrane |
Features
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| From: PS51922 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="BetaCoV S1-NTD #" | |||||||||
| DISULFID | 7 | 146 | disulf | C-x*-C | ||||||||
| DISULFID | 141 | 175 | disulf | C-x*-C | ||||||||
| DISULFID | 153 | 238 | disulf | C-x*-C | ||||||||
| DISULFID | 277 | 287 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 275-345 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [31] All [ 31 ]
- Retrieve set of proteins with 3D structure for this domain