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ProRule PRU01270


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01270
Accession PRU01270
Dates 31-MAR-2020 (Created)
30-SEP-2022 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51922; BCOV_S1_NTD
Name Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain
Function The receptor binding domain (RBD) of betaCoV that directly engages the receptor is commonly located in the C-terminal half of S1 [C-terminal domain (CTD)] such as in SARS-CoV, SARS-CoV-2, MERS-CoV,and BatCoV HKU4, though in rare cases such as with mouse hepatitis virus (MHV), the RBD region was identified in the S1 N-terminal domain (NTD).
Scope(s) Viruses
Betacoronavirus
Example(s) P25194 (SPIKE_CVBV);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the betacoronaviruses spike protein family.

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case
Fusion of virus membrane with host endosomal membrane
Fusion of virus membrane with host membrane
Host cell membrane
Host membrane
Host-virus interaction
Membrane
Transmembrane
Transmembrane helix
Viral attachment to host cell
Viral envelope protein
Viral penetration into host cytoplasm
Virion
Virulence
Virus entry into host cell

Gene Ontology [?]

GO:0016020; Cellular component:membrane
GO:0019064; Biological process:fusion of virus membrane with host plasma membrane
GO:0044173; Cellular component:host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0075509; Biological process:endocytosis involved in viral entry into host cell
GO:0055036; Cellular component:virion membrane
GO:0046813; Biological process:receptor-mediated virion attachment to host cell
GO:0019031; Cellular component:viral envelope
GO:0039654; Biological process:fusion of virus membrane with host endosome membrane
GO:0020002; Cellular component:host cell plasma membrane

Features [?]

From: PS51922
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="BetaCoV S1-NTD #"
DISULFID 7 146 disulf C-x*-C
DISULFID 141 175 disulf C-x*-C
DISULFID 153 238 disulf C-x*-C
DISULFID 277 287 disulf C-x*-C

Additional information [?]

Size range 275-345 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]