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General rule information [?]

Accession PRU01270
Dates 31-MAR-2020 (Created)
30-SEP-2022 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51922; BCOV_S1_NTD
Names Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain; BetaCoV S1-NTD
Function The receptor binding domain (RBD) of betaCoV that directly engages the receptor is commonly located in the C-terminal half of S1 [C-terminal domain (CTD)] such as in SARS-CoV, SARS-CoV-2, MERS-CoV,and BatCoV HKU4, though in rare cases such as with mouse hepatitis virus (MHV), the RBD region was identified in the S1 N-terminal domain (NTD).

Propagated annotation [?]

Comments [?]

Similarity Belongs to the betacoronaviruses spike protein family.

Gene Ontology [?]

GO:0016020; Cellular component: membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0044173; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment membrane.
GO:0075509; Biological process: endocytosis involved in viral entry into host cell.
GO:0055036; Cellular component: virion membrane.
GO:0046813; Biological process: receptor-mediated virion attachment to host cell.
GO:0019031; Cellular component: viral envelope.
GO:0039654; Biological process: fusion of virus membrane with host endosome membrane.
GO:0020002; Cellular component: host cell plasma membrane.

Keywords [?]

case <FTTag:disulf>
end case

Features [?]

From: PS51922
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       BetaCoV S1-NTD #        
DISULFID     7     146           disulf   C-x*-C  
DISULFID     141     175           disulf   C-x*-C  
DISULFID     153     238           disulf   C-x*-C  
DISULFID     277     287           disulf   C-x*-C  

Additional information [?]

Size range 275-345 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P25194 (SPIKE_CVBV)
Viruses; Betacoronavirus
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]