PRU01270

General rule information [?]

Accession	PRU01270
Dates	31-MAR-2020 (Created) 30-SEP-2022 (Last updated, Version 3)

Data class

Domain

Predictors

PROSITE; PS51922; BCOV_S1_NTD

Names

Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain; BetaCoV S1-NTD

Function

The receptor binding domain (RBD) of betaCoV that directly engages the receptor is commonly located in the C-terminal half of S1 [C-terminal domain (CTD)] such as in SARS-CoV, SARS-CoV-2, MERS-CoV,and BatCoV HKU4, though in rare cases such as with mouse hepatitis virus (MHV), the RBD region was identified in the S1 N-terminal domain (NTD).

Propagated annotation [?]

Comments [?]

Similarity

Belongs to the betacoronaviruses spike protein family.

Gene Ontology [?]

GO:0016020; Cellular component: membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0044173; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment membrane.
GO:0075509; Biological process: endocytosis involved in viral entry into host cell.
GO:0055036; Cellular component: virion membrane.
GO:0046813; Biological process: receptor-mediated virion attachment to host cell.
GO:0019031; Cellular component: viral envelope.
GO:0039654; Biological process: fusion of virus membrane with host endosome membrane.
GO:0020002; Cellular component: host cell plasma membrane.

Keywords [?]

case <FTTag:disulf>

Disulfide bond

end case

Fusion of virus membrane with host endosomal membrane
Fusion of virus membrane with host membrane
Host cell membrane
Host membrane
Host-virus interaction
Membrane
Transmembrane
Transmembrane helix
Viral attachment to host cell
Viral envelope protein
Viral penetration into host cytoplasm
Virion
Virulence
Virus entry into host cell

Features [?]

From: PS51922

Key From To Description Tag Condition FTGroup

DOMAIN from to BetaCoV S1-NTD #

DISULFID 7 146 disulf C-x*-C

DISULFID 141 175 disulf C-x*-C

DISULFID 153 238 disulf C-x*-C

DISULFID 277 287 disulf C-x*-C

Additional information [?]

Size range	275-345 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P25194 (SPIKE_CVBV)
Scope	Viruses; Betacoronavirus
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Viruses [31]
Retrieve set of proteins with 3D structure for this domain