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| annotation rule: PRU01270 |
General rule information
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| Accession | PRU01270 |
| Dates | 31-MAR-2020 (Created) 3-JUN-2021 (Last updated, Version 2) |
| Data class | Domain |
| Predictors | PROSITE; PS51922; BCOV_S1_NTD |
| Names | Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain; BetaCoV S1-NTD |
| Function | The receptor binding domain (RBD) of betaCoV that directly engages the receptor is commonly located in the C-terminal half of S1 [C-terminal domain (CTD)] such as in SARS-CoV, SARS-CoV-2, MERS-CoV,and BatCoV HKU4, though in rare cases such as with mouse hepatitis virus (MHV), the RBD region was identified in the S1 N-terminal domain (NTD). |
Propagated annotation
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Comments
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| Similarity | Belongs to the betacoronaviruses spike protein family. |
Gene Ontology
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GO:0016021; Cellular component: integral component of membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0044173; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment membrane.
GO:0075509; Biological process: endocytosis involved in viral entry into host cell.
GO:0055036; Cellular component: virion membrane.
GO:0046813; Biological process: receptor-mediated virion attachment to host cell.
GO:0019031; Cellular component: viral envelope.
GO:0039654; Biological process: fusion of virus membrane with host endosome membrane.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0044173; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment membrane.
GO:0075509; Biological process: endocytosis involved in viral entry into host cell.
GO:0055036; Cellular component: virion membrane.
GO:0046813; Biological process: receptor-mediated virion attachment to host cell.
GO:0019031; Cellular component: viral envelope.
GO:0039654; Biological process: fusion of virus membrane with host endosome membrane.
GO:0020002; Cellular component: host cell plasma membrane.
Keywords
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case <FTTag:disulf>
end case
Fusion of virus membrane with host endosomal membrane
Fusion of virus membrane with host membrane
Host cell membrane
Host membrane
Host-virus interaction
Membrane
Transmembrane
Transmembrane helix
Viral attachment to host cell
Viral envelope protein
Viral penetration into host cytoplasm
Virion
Virulence
Virus entry into host cell
Fusion of virus membrane with host membrane
Host cell membrane
Host membrane
Host-virus interaction
Membrane
Transmembrane
Transmembrane helix
Viral attachment to host cell
Viral envelope protein
Viral penetration into host cytoplasm
Virion
Virulence
Virus entry into host cell
Features
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| From: PS51922 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | BetaCoV S1-NTD # | |||||||||
| DISULFID | 7 | 146 | disulf | C-x*-C | ||||||||
| DISULFID | 141 | 175 | disulf | C-x*-C | ||||||||
| DISULFID | 153 | 238 | disulf | C-x*-C | ||||||||
| DISULFID | 277 | 287 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 275-345 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P25194 (SPIKE_CVBV) |
| Scope | Viruses; Betacoronavirus |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Viruses [31]
- Retrieve set of proteins with 3D structure for this domain