PRU01272

Accession	PRU01272
Dates	14-APR-2020 (Created) 30-SEP-2022 (Last updated, Version 3)

Data class

Domain

Predictors

PROSITE; PS51924; COV_S2_HR2

Name	Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region

Function

The S2 subunit contains two 4-3 heptad repeats (HRs) of hydrophobic residues, HR1 and HR2, typical of coiled coils, separated by an ~170-aa-long intervening domain. The S2 subunit is expected to present rearrangement of its HRs to form a stable 6-helix bundle fusion core.

GO:0016020; Cellular component: membrane.
GO:0044173; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment membrane.
GO:0055036; Cellular component: virion membrane.
GO:0019031; Cellular component: viral envelope.
GO:0039654; Biological process: fusion of virus membrane with host endosome membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0075509; Biological process: endocytosis involved in viral entry into host cell.
GO:0046813; Biological process: receptor-mediated virion attachment to host cell.

Coiled coil
Host membrane
Host-virus interaction
Membrane
Viral attachment to host cell
Viral envelope protein
Virion
Virulence
Virus entry into host cell

From: PS51924

Key

From

To

Description

Tag

Condition

FTGroup

REGION

from

to

Heptad repeat 2 (HR2) #

Size range	80-100 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P12650 (SPIKE_IBVK)
Scope	Viruses; Orthocoronavirinae
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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