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General rule information [?]

Accession PRU01272
Dates 14-APR-2020 (Created)
30-SEP-2022 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51924; COV_S2_HR2
Name Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region
Function The S2 subunit contains two 4-3 heptad repeats (HRs) of hydrophobic residues, HR1 and HR2, typical of coiled coils, separated by an ~170-aa-long intervening domain. The S2 subunit is expected to present rearrangement of its HRs to form a stable 6-helix bundle fusion core.

Propagated annotation [?]

Gene Ontology [?]

GO:0016020; Cellular component: membrane.
GO:0044173; Cellular component: host cell endoplasmic reticulum-Golgi intermediate compartment membrane.
GO:0055036; Cellular component: virion membrane.
GO:0019031; Cellular component: viral envelope.
GO:0039654; Biological process: fusion of virus membrane with host endosome membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0075509; Biological process: endocytosis involved in viral entry into host cell.
GO:0046813; Biological process: receptor-mediated virion attachment to host cell.

Keywords [?]

Features [?]

From: PS51924
Key     From     To       Description   Tag   Condition   FTGroup
REGION     from     to       Heptad repeat 2 (HR2) #        

Additional information [?]

Size range 80-100 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P12650 (SPIKE_IBVK)
Viruses; Orthocoronavirinae
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]