PROSITE entry PS51924
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General information about the entry
Entry name [info] | COV_S2_HR2 |
Accession [info] | PS51924 |
Entry type [info] | MATRIX |
Date [info] |
17-JUN-2020 CREATED;
07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
PROSITE Doc. [info] | PDOC51923 |
Associated ProRule [info] | PRU01272 |
Name and characterization of the entry
Description [info] | Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. |
Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=82; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=77; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.8437381; R2=0.0062844; TEXT='-LogE'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=13910.6914062; R2=4.1364145; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1378; H_SCORE=19611; N_SCORE=11.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=582; H_SCORE=16318; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-35; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='P'; M= -64, -84, 4, -56, -76, -68, -67, 1, -62, -16, -63, 13, 110, -64, -73, -14, -8, -66, -81, -75; /M: SY='D'; M= 24, -73, 53, 29, -81, -59, -57, -75, -53, -76, -69, 2, 34, 42, -59, 47, -6, -70, -83, -70; /M: SY='Y'; M= -65, -72, 4, -64, 43, -73, -54, -49, -64, 39, -47, 33, -77, 19, -65, -14, 6, -16, -56, 71; /M: SY='P'; M= -65, -78, -10, -64, 46, -76, -67, 44, -9, -9, -51, -68, 72, 1, -68, -15, -59, 5, -65, 19; /M: SY='D'; M= -61, -76, 89, -44, -83, 19, -53, -82, -55, -84, -77, 67, 15, -54, -63, 14, -53, -80, -93, -72; /M: SY='F'; M= -66, -71, -78, -79, 91, -15, -71, 48, -74, -42, -48, 12, -79, -78, -75, -66, -9, 28, -57, -36; /M: SY='N'; M= -62, -75, 64, 41, -75, -14, -50, -76, -9, -75, 13, 76, -67, 18, -56, -51, -8, -75, -84, 3; /M: SY='E'; M= 21, -75, 27, 55, 11, -16, 17, -75, 44, -71, -66, -52, -63, 33, -48, -52, 6, -69, -75, -61; /M: SY='E'; M= -59, -75, 31, 86, -79, -72, -58, -75, -48, -73, -70, -52, 19, -44, -58, -50, 63, -68, -84, -71; /M: SY='F'; M= -70, -73, -82, -74, 94, -82, -68, 14, -73, 37, -43, -76, 6, 19, -72, -72, -64, -13, -54, -34; /M: SY='D'; M= -14, -76, 66, 47, -82, -63, -52, -80, 13, -78, -71, 47, -65, 38, 9, 10, -55, -76, -85, -69; /M: SY='E'; M= -61, -79, 52, 80, -80, -4, -55, -80, 43, -31, -70, 5, -61, -42, -48, -56, -59, -76, -82, -70; /M: SY='W'; M= -67, -78, 8, -73, 20, -81, -67, 56, -73, 25, 22, -74, -78, -70, -73, -72, -64, 2, 94, 59; /M: SY='F'; M= -4, -75, -81, -77, 81, -79, -62, 30, -70, 6, 10, -75, -80, -72, -12, -69, -65, -48, 59, 65; /M: SY='K'; M= -21, -74, 31, 18, -77, -11, -58, -68, 49, -72, -65, 12, -65, 37, 10, 7, 24, 1, -81, -67; /M: SY='N'; M= -59, -71, -43, 24, 1, 17, -50, -76, -4, -77, -68, 97, -69, 10, -13, -9, -9, -75, -82, -66; /M: SY='Q'; M= -63, -74, -72, -63, -51, -78, 43, 27, -64, 44, 34, -66, -74, 56, -64, -62, 22, 1, 50, 11; /I: I=-21; MI=0; MD=-53; IM=0; DM=-53; /M: SY='N'; M= -55, -69, -47, -53, -75, -56, 28, -73, 20, -77, -66, 83, -2, 17, -53, 51, 34, -70, -87, -66; /M: SY='H'; M= -60, -73, -59, -59, -55, -66, 51, -63, -7, 6, 15, 44, -71, 17, 19, 30, 21, -64, 48, 50; /M: SY='T'; M= 3, -68, 6, 24, 7, -67, -63, -12, -58, -11, 16, 8, -66, 3, -64, 16, 58, 14, -79, -60; /M: SY='N'; M= 15, -69, -63, -15, 27, 5, -64, -7, 14, 28, -51, 29, -71, -60, -62, 2, 25, -11, -73, -57; /M: SY='P'; M= -62, -80, 5, 33, -70, -71, -63, -3, -58, 11, 12, -3, 86, 19, -66, -6, -57, -18, -79, -69; /M: SY='Q'; M= -9, -72, -47, 47, -77, -62, -54, -67, -49, -71, -64, 56, -1, 66, -55, 28, 25, -6, -82, -68; /M: SY='L'; M= -66, -70, -81, -74, 58, -82, -68, 20, -74, 69, -36, -75, -80, 0, -73, -17, -10, -42, -64, -44; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='K'; M= -70, -85, -73, -8, 17, -18, -73, -14, 45, 6, -65, -68, -80, 21, -60, 22, -67, -70, 41, -64; D=-38; /I: I=-38; DM=-97; /M: SY='D'; M= -58, -71, 76, -6, -79, -57, -52, -78, -5, -80, -73, 74, -67, -50, -58, 41, 16, -74, -93, -69; /M: SY='I'; M= -20, -72, -71, 19, 30, -23, -71, 48, -67, 27, -43, -70, -74, 14, -70, -64, -11, 40, -71, -54; /M: SY='F'; M= -19, -70, -64, -65, 63, -19, -60, -9, 3, -24, -57, 26, -3, -61, -63, 44, 23, -58, -61, 33; /I: I=-33; MD=-84; /M: SY='N'; M= 7, 25, 9, -73, 24, -22, -73, -21, -74, -81, -78, 48, -8, -73, -80, 27, -65, -76, -90, -73; D=-33; /I: I=-33; MI=0; MD=-84; IM=0; DM=-84; /M: SY='N'; M= -59, -67, 33, -53, -76, -54, -48, -74, -50, -79, -69, 108, -69, -52, -59, 5, 41, -72, -95, -70; /M: SY='M'; M= 35, -71, -72, -65, 39, -70, 23, 22, -66, 16, 61, -4, 6, 26, -67, -60, -59, -3, -70, -51; /M: SY='T'; M= -51, -68, -53, 24, -75, -60, -61, -69, -55, -73, -67, 9, 51, -53, -63, 66, 68, -64, -84, -69; /M: SY='Y'; M= -64, -74, -74, -73, 24, -80, -59, 44, -1, 5, 26, -1, -78, -66, -66, -67, -59, 35, -54, 81; /M: SY='L'; M= -64, -68, -80, -76, 9, -83, -69, -31, -75, 79, -33, 0, -83, -71, -74, -73, -60, 35, -72, -53; /M: SY='N'; M= -64, -71, 69, -48, -74, -55, -46, -77, -51, -81, -72, 105, -71, -52, -59, -47, -1, -77, -91, 3; /M: SY='L'; M= -66, -71, -85, -79, 26, -87, -73, 44, -78, 73, -32, -81, -82, -74, -77, -75, -61, 13, -69, -50; /M: SY='T'; M= -52, -67, -55, -56, -63, -61, -57, -16, 19, -67, -62, 31, -65, 15, -55, 58, 69, -59, -74, 34; /M: SY='D'; M= 7, -74, 39, 37, -9, 10, -55, -70, 10, -70, -65, 37, -67, 17, -56, -11, -4, -21, -72, 35; /M: SY='E'; M= -61, -82, -39, 93, -71, -74, 38, -79, -44, -72, -65, -55, -60, 65, -50, -56, -62, -76, -70, 38; /M: SY='M'; M= -60, -71, -76, -75, -52, -79, -70, 73, -71, 13, 77, 5, -73, -67, -73, -10, 9, 18, -77, -57; /M: SY='N'; M= 47, 32, 49, 39, -78, -60, -56, -73, -52, -32, -66, 50, -67, 44, -59, -49, -55, -67, -84, -70; /I: I=-21; MI=0; MD=-53; IM=0; DM=-53; /M: SY='E'; M= -10, -73, 7, 48, -64, -72, 17, -13, -15, 26, -53, 32, -69, -51, 34, -58, -9, 8, -81, -63; /M: SY='L'; M= -66, -72, -84, -79, 16, -87, -71, 60, -77, 66, -33, -80, -81, -73, -76, -75, -61, 0, -66, 18; /M: SY='Q'; M= -58, -76, 43, -1, -82, -62, -50, -77, 7, -76, -66, 56, -67, 86, 1, 24, -7, -75, -82, -66; /M: SY='N'; M= -57, -73, 54, 45, -76, 9, -54, -75, -5, -14, -68, 57, -66, -48, -58, 43, -51, -72, -85, -69; /M: SY='I'; M= -10, -71, -77, -72, 7, -78, -69, 55, -70, 29, -41, -70, -75, 7, -72, -14, 9, 38, -68, 31; /M: SY='I'; M= 34, -70, -73, -72, -58, -70, -75, 78, -70, -44, -45, 3, -71, -66, -74, 26, -52, 28, -78, -62; /M: SY='H'; M= -62, -78, 48, 35, -73, -67, 62, -78, 31, -74, -65, 24, -66, 54, -4, -13, -1, -76, -79, 14; /M: SY='N'; M= -55, -72, -46, 25, -80, 14, -52, -78, 29, -79, -68, 75, -66, 53, -49, 44, -50, -75, -81, -69; /M: SY='L'; M= -63, -71, -85, -79, -46, -87, -77, 59, -78, 63, -33, -80, -80, -74, -77, -74, -59, 45, -75, -56; /M: SY='N'; M= -60, -68, -41, -56, -73, -53, -47, -71, 23, -17, -65, 110, -71, -49, -52, 23, -47, -73, -89, -69; /M: SY='N'; M= -24, -74, 41, 20, -81, 15, -53, -79, 34, -79, -69, 57, -66, 52, -50, 26, -53, -76, -82, -69; /M: SY='T'; M= -53, -67, 4, -60, -60, -63, -59, -57, -60, 1, 61, -52, 8, -57, -65, 62, 62, -56, -76, 22; /M: SY='Y'; M= -67, -72, -68, -70, 44, -76, 26, -2, -63, 42, -44, 34, -79, -64, 5, -64, 6, -14, -58, 63; /M: SY='I'; M= -59, -71, -80, -78, -52, -84, -81, 74, -75, -3, -39, 6, -77, -74, -77, -68, -54, 72, -81, -59; /M: SY='D'; M= -64, -75, 97, 23, -82, -62, -52, -80, -52, -81, -76, 59, -66, -51, -61, -50, 27, -76, -97, -70; /M: SY='L'; M= -63, -69, -81, -74, -45, -83, -71, -32, -75, 78, -33, -79, 6, -71, -75, -71, 1, 36, -75, -56; /M: SY='E'; M= -58, -76, -43, 80, 4, -69, 31, -78, 47, -73, -67, -52, -61, 8, -45, 35, -55, -73, -76, -62; /M: SY='W'; M= -65, -85, -55, 66, -62, -74, -65, -7, 25, -30, -64, -64, -66, 54, -52, -63, -67, -71, 126, -51; /M: SY='L'; M= -67, -69, -80, -76, 53, -82, -67, -4, -75, 71, 36, 6, -82, -71, -73, -73, -62, -3, -65, -45; /M: SY='N'; M= -57, -72, -50, -57, 9, 48, -55, -77, 38, -77, -68, 80, -69, 20, -53, 16, -54, -76, -77, -65; /M: SY='R'; M= -61, -76, -61, -51, -72, -74, -59, -6, 53, -66, -59, -53, -68, 24, 78, -54, 45, -8, -77, -63; /M: SY='Y'; M= -65, -75, -74, -75, 39, -14, -51, -4, -69, -11, -48, -71, -80, -67, -68, -64, 1, 30, -42, 106; /M: SY='E'; M= -57, -75, -44, 85, -74, -76, -59, -59, -46, -65, -62, -57, -61, 17, 8, -54, 40, 33, -82, -68; /M: SY='T'; M= -59, -72, -58, -54, -62, -70, -55, -59, 7, -17, 16, 31, -69, 60, 37, -50, 61, -4, -73, 30; /M: SY='Y'; M= -70, -81, -68, -68, 12, -77, 32, -58, -63, -54, -51, -67, -80, 15, -61, -63, -11, -63, -33, 125; /I: I=-45; MI=0; MD=-115; IM=0; DM=-115; /M: SY='V'; M= -56, -71, -75, -16, -56, -79, -78, 63, -71, -16, -44, -71, 10, -69, -75, 19, -52, 69, -81, -61; /M: SY='K'; M= -62, -76, -53, -42, -79, -67, -57, -79, 106, -78, -66, 13, -63, -40, -26, -14, -55, -75, -74, -66; /M: SY='W'; M= -74, -98, -99, -79, -42, -73,-100, -72, -71, -71, -73, -91, -78, -71, -75, -78, -2, -85, 176, -28; /M: SY='P'; M= -8, -89, -67, -56, -85, -67, -70, -73, -63, -83, -70, -72, 125, -66, -75, -62, -58, -77, -79, -83; /M: SY='W'; M= -76,-101,-103, -80, -40, -74,-103, -73, -72, -71, -74, -96, -79, -72, -76, -82, -88, -88, 179, -27; /M: SY='W'; M= -71, -87, -78, -76, -27, -14, -51, -63, -68, -60, -57, -77, -81, -64, -67, -70, -72, -70, 132, 114; /M: SY='V'; M= -8, -69, -80, -72, -56, -81, -81, 42, -71, -41, -43, -75, -76, 17, -73, -64, -53, 89, -83, -61; /M: SY='W'; M= -76,-101,-103, -80, -40, -74,-103, -73, -72, -71, -74, -96, -79, -72, -76, -82, -88, -88, 179, -27; /M: SY='L'; M= -66, -69, -84, -77, -41, -86, -69, -31, -78, 90, -29, -84, -84, -71, -75, -77, -62, -6, -72, -54; /M: SY='A'; M= 53, -69, -74, -71, -59, 32, -73, 51, -70, 30, -47, -66, -71, -67, -74, -55, -15, -42, -74, -64; /M: SY='I'; M= -65, -76, -86, -83, 21, -88, -79, 99, -77, -32, 62, -75, -74, -74, -79, -73, -59, -23, -70, -51; /I: I=-45; MD=-115; /M: SY='F'; M= 31, -76, 1, -74, 55, 7, -77, -21, -76, -65, -66, -68, -81, -74, -79, 27, -62, 14, -75, -58; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='I'; M= -65, -73, -86, -81, 47, -86, -76, 74, -77, 35, 38, -78, -78, -75, -78, -73, -60, 24, -67, -47; /M: SY='A'; M= 68, 27, -73, -67, -63, -62, -73, -5, -67, 3, -51, -66, -72, -65, -71, -6, -9, 47, -80, -66; /M: SY='W'; M= -63, 57, -79, -77, 51, 31, -71, -10, -74, 47, 21, -70, -79, -73, -75, -66, 1, -52, 62, -48; /M: SY='I'; M= -16, 20, -79, -76, -50, -82, -76, 70, -74, 47, -37, -72, -75, -71, -76, -65, 31, 8, -76, -58; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
Total number of hits | 50 in 50 different sequences |
Number of true positive hits | 50 in 50 different sequences |
Number of 'unknown' hits | 0 |
Number of false positive hits | 0 |
Number of false negative sequences | 0 |
Number of 'partial' sequences | 0 |
Precision (true positives / (true positives + false positives)) | 100.00 % |
Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
Taxonomic range [info] | Eukaryotic viruses |
Maximum number of repetitions [info] | 1 |
Matrix type [info] | protein_domain |
Scaling database [info] | reversed |
Author [info] | CJA_Sigrist |
Feature key [info] | REGION |
Feature description [info] | Heptad repeat 2 (HR2) |
Version [info] | 2 |
Cross-references [info]