PRU01275

Accession	PRU01275
Dates	15-JUN-2020 (Created) 30-SEP-2022 (Last updated, Version 2)

Data class

Domain

Predictors

PROSITE; PS51927; COV_M

Name	Coronavirus membrane (CoV M) protein

Function

The CoV M protein, which functions as a homodimer, adapts a region of membrane for virus assembly and captures other structural proteins at the budding site.

Function	Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
Subunit	Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

GO:0016020; Cellular component: membrane.
GO:0055036; Cellular component: virion membrane.
GO:0019031; Cellular component: viral envelope.
GO:0019058; Biological process: viral life cycle.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0039660; Molecular function: structural constituent of virion.

Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Viral matrix protein
Virion

Size range	210-250 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q5MQC7 (VME1_CVHN1)
Scope	Viruses; Riboviria
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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• UniProtKB/Swiss-Prot sets
  

  Viruses

  [55]

  
  
• Retrieve set of proteins with 3D structure for this domain