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General rule information [?]

Accession PRU01275
Dates 15-JUN-2020 (Created)
30-SEP-2022 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51927; COV_M
Name Coronavirus membrane (CoV M) protein
Function The CoV M protein, which functions as a homodimer, adapts a region of membrane for virus assembly and captures other structural proteins at the budding site.

Propagated annotation [?]

Comments [?]

Function Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
Subunit Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Gene Ontology [?]

GO:0016020; Cellular component: membrane.
GO:0055036; Cellular component: virion membrane.
GO:0019031; Cellular component: viral envelope.
GO:0019058; Biological process: viral life cycle.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0039660; Molecular function: structural constituent of virion.

Keywords [?]

Additional information [?]

Size range 210-250 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q5MQC7 (VME1_CVHN1)
Viruses; Riboviria
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]