ProRule PRU01275

General rule information [?]

Accession PRU01275
Dates 15-JUN-2020 (Created)
30-SEP-2022 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51927; COV_M
Name Coronavirus membrane (CoV M) protein
Function The CoV M protein, which functions as a homodimer, adapts a region of membrane for virus assembly and captures other structural proteins at the budding site.
Scope(s) Viruses
Example(s) Q5MQC7 (VME1_CVHN1);

Propagated annotation [?]

Comments [?]

FUNCTIONComponent of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
SUBUNITHomomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Keywords [?]

Gene Ontology [?]

GO:0016020; Cellular component:membrane
GO:0055036; Cellular component:virion membrane
GO:0019031; Cellular component:viral envelope
GO:0019058; Biological process:viral life cycle
GO:0044178; Cellular component:host cell Golgi membrane
GO:0039660; Molecular function:structural constituent of virion

Features [?]

Additional information [?]

Size range 210-250 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]