ProRule PRU01275
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01275 |
| Accession | PRU01275 |
| Dates | 15-JUN-2020 (Created)
30-SEP-2022 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51927; COV_M |
Name | Coronavirus membrane (CoV M) protein |
| Function | The CoV M protein, which functions as a homodimer, adapts a region of membrane for virus assembly and captures other structural proteins at the budding site. |
| Scope(s) |
Viruses Riboviria |
| Example(s) | Q5MQC7 (VME1_CVHN1); |
Propagated annotation
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Comments
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| FUNCTION | Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins. |
| SUBUNIT | Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus. |
Keywords
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| Host Golgi apparatus |
| Host membrane |
| Membrane |
| Transmembrane |
| Transmembrane helix |
| Viral envelope protein |
| Viral matrix protein |
| Virion |
Gene Ontology
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| GO:0016020; Cellular component:membrane |
| GO:0055036; Cellular component:virion membrane |
| GO:0019031; Cellular component:viral envelope |
| GO:0019058; Biological process:viral life cycle |
| GO:0044178; Cellular component:host cell Golgi membrane |
| GO:0039660; Molecular function:structural constituent of virion |
Features
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Additional information
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| Size range | 210-250 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [55] All [ 55 ]
- Retrieve set of proteins with 3D structure for this domain