PRU01275
General rule information
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Accession | PRU01275 |
Dates | 15-JUN-2020 (Created) 30-SEP-2022 (Last updated, Version 2) |
Data class | Domain |
Predictors | PROSITE; PS51927; COV_M |
Name | Coronavirus membrane (CoV M) protein |
Function | The CoV M protein, which functions as a homodimer, adapts a region of membrane for virus assembly and captures other structural proteins at the budding site. |
Propagated annotation
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Comments
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Function | Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins. |
Subunit | Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus. |
Gene Ontology
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GO:0016020; Cellular component: membrane.
GO:0055036; Cellular component: virion membrane.
GO:0019031; Cellular component: viral envelope.
GO:0019058; Biological process: viral life cycle.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0039660; Molecular function: structural constituent of virion.
GO:0055036; Cellular component: virion membrane.
GO:0019031; Cellular component: viral envelope.
GO:0019058; Biological process: viral life cycle.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0039660; Molecular function: structural constituent of virion.
Keywords
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Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Viral matrix protein
Virion
Host membrane
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Viral matrix protein
Virion
Additional information
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Size range | 210-250 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q5MQC7 (VME1_CVHN1) |
Scope | Viruses; Riboviria |
Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Viruses [55]
- Retrieve set of proteins with 3D structure for this domain