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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01275


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PURL: https://purl.expasy.org/prosite/rule/PRU01275
General rule information [?]

Accession PRU01275
Dates 15-JUN-2020 (Created)
30-SEP-2022 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51927; COV_M
Name Coronavirus membrane (CoV M) protein
Function The CoV M protein, which functions as a homodimer, adapts a region of membrane for virus assembly and captures other structural proteins at the budding site.
Scope(s) Viruses
Riboviria
Example(s) Q5MQC7;

Propagated annotation [?]

Comments [?]

FUNCTIONComponent of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
SUBUNITHomomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Keywords [?]

Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix
Viral envelope protein
Viral matrix protein
Virion

Gene Ontology [?]

GO:0016020; Cellular component:membrane
GO:0055036; Cellular component:virion membrane
GO:0019031; Cellular component:viral envelope
GO:0019058; Biological process:viral life cycle
GO:0044178; Cellular component:host cell Golgi membrane
GO:0039660; Molecular function:structural constituent of virion

Features [?]


Additional information [?]

Size range 210-250 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]