ProRule PRU01282
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01282 |
| Accession | PRU01282 |
| Dates | 28-JUL-2020 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51353; ARSC |
Name | ArsC family |
| Function | ArsC is an ~150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite with a redox active cysteine residue in the active site. The arsC family also comprises the Spx proteins which are GRAM-positive bacterial transcription factors that regulate the transcription of multiple genes in response to disulfide stress. |
| Scope(s) |
Bacteria Viruses Fromanvirus |
| Example(s) | P52147 (ARSC2_ECOLX); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the ArsC family. |
Keywords
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| case <FTTag:disulf> | |
| Disulfide bond | |
| Redox-active center | |
| end case | |
| case <Feature:PS51353:10-13=C-x*-C> | |
Features
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| From: PS51353 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <Feature:PS51353:10-13=C-x*-C> | ||||||||||||
| DISULFID | 10 | 13 | /note="Redox-active" | disulf | ||||||||
| else case <Feature:PS51353:10=C> | ||||||||||||
| ACT_SITE | 10 | 10 | ArsC | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 110-135 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [63] All [ 63 ]
- Retrieve set of proteins with 3D structure for this domain