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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01282


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01282
General rule information [?]

Accession PRU01282
Dates 28-JUL-2020 (Created)
28-JUL-2020 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51353; ARSC
Name ArsC family
Function ArsC is an ~150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite with a redox active cysteine residue in the active site. The arsC family also comprises the Spx proteins which are GRAM-positive bacterial transcription factors that regulate the transcription of multiple genes in response to disulfide stress.
Scope(s) Bacteria
Viruses
Fromanvirus
Example(s) P52147;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the ArsC family.

Keywords [?]

case <FTTag:disulf>
Disulfide bond
Redox-active center
end case
case <Feature:PS51353:10-13=C-x*-C>

Features [?]

From: PS51353
Key From To Description Tag Condition FTGroup
case <Feature:PS51353:10-13=C-x*-C>
DISULFID 10 13 /note="Redox-active" disulf
else case <Feature:PS51353:10=C>
ACT_SITE 10 10 ArsC
end case

Additional information [?]

Size range 110-135 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]