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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01284


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01284
General rule information [?]

Accession PRU01284
Dates 11-AUG-2020 (Created)
16-FEB-2023 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51935; NLPC_P60
Name NlpC/P60 domain
Function The NlpC/P60 domain consists of ~110-140 residues and is a primitive papain-like peptidase in the CA clan of cysteine peptidase with a Cys/His/His catalytic triad and a conserved catalytic core.
Scope(s) Bacteria
Viruses
Caudoviricetes
Example(s) P0AFV7;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=3.4.-.-;
end case

Comments [?]

SIMILARITYBelongs to the peptidase C40 family.

Keywords [?]

Hydrolase
Protease
Thiol protease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008234; Molecular function:cysteine-type peptidase activity

Features [?]

From: PS51935
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="NlpC/P60 #"
ACT_SITE 31 31 /note="Nucleophile" C 1
ACT_SITE 82 82 /note="Proton acceptor" H 1
ACT_SITE 94 94 [DEHNQ] 1

Additional information [?]

Size range 110-150 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]