ProRule PRU01284
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01284 |
| Accession | PRU01284 |
| Dates | 11-AUG-2020 (Created)
16-FEB-2023 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51935; NLPC_P60 |
Name | NlpC/P60 domain |
| Function | The NlpC/P60 domain consists of ~110-140 residues and is a primitive papain-like peptidase in the CA clan of cysteine peptidase with a Cys/His/His catalytic triad and a conserved catalytic core. |
| Scope(s) |
Bacteria Viruses Caudoviricetes |
| Example(s) | P0AFV7 (MEPS_SHIFL); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + RecName: EC=3.4.-.-; |
| end case | |
Comments
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| SIMILARITY | Belongs to the peptidase C40 family. |
Keywords
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| Hydrolase | |
| Protease | |
| Thiol protease | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0008234; Molecular function:cysteine-type peptidase activity | |
Features
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| From: PS51935 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="NlpC/P60 #" | |||||||||
| ACT_SITE | 31 | 31 | /note="Nucleophile" | C | 1 | |||||||
| ACT_SITE | 82 | 82 | /note="Proton acceptor" | H | 1 | |||||||
| ACT_SITE | 94 | 94 | [DEHNQ] | 1 | ||||||||
Additional information
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| Size range | 110-150 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [36] Viruses [3] All [ 39 ]
- Retrieve set of proteins with 3D structure for this domain