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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01295


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01295
General rule information [?]

Accession PRU01295
Dates 02-DEC-2020 (Created)
02-DEC-2020 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51950; COV_NSP8
Name Coronavirus RNA-dependent RNA polymerase (RdRp) Nsp8 cofactor domain
Function The Nsp12 RNA-dependent RNA polymerase, that includes an RdRp catalytic domain conserved in all RNA viruses, possesses some minimal activity on its own, but the addition of the Nsp7 and Nsp8 cofactors greatly stimulates polymerase activity.
Scope(s) Viruses
Orthocoronavirinae
Example(s) P0C6Y1;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Features [?]

From: PS51950
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="RdRp Nsp8 cofactor #"

Additional information [?]

Size range 190-215 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]