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annotation rule: PRU01295

General rule information [?]

Accession PRU01295
Dates 2-DEC-2020 (Created)
2-DEC-2020 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51950; COV_NSP8
Name Coronavirus RNA-dependent RNA polymerase (RdRp) Nsp8 cofactor domain
Function The Nsp12 RNA-dependent RNA polymerase, that includes an RdRp catalytic domain conserved in all RNA viruses, possesses some minimal activity on its own, but the addition of the Nsp7 and Nsp8 cofactors greatly stimulates polymerase activity.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the coronaviruses polyprotein 1ab family.

Features [?]

From: PS51950
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       RdRp Nsp8 cofactor #        

Additional information [?]

Size range 190-215 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6Y1 (R1AB_IBVB)
Scope
Viruses; Orthocoronavirinae
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]