ProRule PRU01295
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01295 |
| Accession | PRU01295 |
| Dates | 2-DEC-2020 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51950; COV_NSP8 |
Name | Coronavirus RNA-dependent RNA polymerase (RdRp) Nsp8 cofactor domain |
| Function | The Nsp12 RNA-dependent RNA polymerase, that includes an RdRp catalytic domain conserved in all RNA viruses, possesses some minimal activity on its own, but the addition of the Nsp7 and Nsp8 cofactors greatly stimulates polymerase activity. |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P0C6Y1 (R1AB_IBVB); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Features
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| From: PS51950 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="RdRp Nsp8 cofactor #" | |||||||||
Additional information
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| Size range | 190-215 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [59] All [ 59 ]
- Retrieve set of proteins with 3D structure for this domain