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ProRule PRU01299
General rule information
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| Accession | PRU01299 |
| Dates | 13-JAN-2021 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51954; COV_N7_MTASE |
Name | The Coronavirus (CoV) guanine-N7-methyltransferase (N7-MTase) domain |
| Function | The S-adenosyl methionine (SAM)-dependent guanine-N7- methyltransferase (N7-MTase) domain methylates the 5' guanine of the Gppp-RNA at the N7 position for mRNA capping. |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P0C6X7 (R1AB_SARS); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Keywords
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| Methyltransferase | |
| Transferase | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| Zinc-finger | |
| end case | |
Gene Ontology
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| GO:0032259; Biological process:methylation |
| GO:0008168; Molecular function:methyltransferase activity |
Features
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| From: PS51954 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="N7-MTase #" | |||||||||
| BINDING | 36 | 42 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D-x-G-x-P-x-[GA] | ||||||||
| REGION | 116 | 130 | /note="GpppA-binding" | |||||||||
| BINDING | 154 | 154 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
C | 1 | |||||||
| BINDING | 174 | 174 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
C | 1 | |||||||
| BINDING | 185 | 185 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
C | 1 | |||||||
| BINDING | 188 | 188 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
H | 1 | |||||||
Additional information
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| Size range | 220-235 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [30] All [ 30 ]
- Retrieve set of proteins with 3D structure for this domain