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annotation rule: PRU01299

General rule information [?]

Accession PRU01299
Dates 13-JAN-2021 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51954; COV_N7_MTASE
Name The Coronavirus (CoV) guanine-N7-methyltransferase (N7-MTase) domain
Function The S-adenosyl methionine (SAM)-dependent guanine-N7- methyltransferase (N7-MTase) domain methylates the 5' guanine of the Gppp-RNA at the N7 position for mRNA capping.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the coronaviruses polyprotein 1ab family.

Gene Ontology [?]

GO:0032259; Biological process: methylation.
GO:0008168; Molecular function: methyltransferase activity.

Keywords [?]

Methyltransferase
Transferase
case <FTGroup:1>
Metal-binding
Zinc
Zinc-finger
end case


Features [?]

From: PS51954
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       N7-MTase #        
BINDING     36     42       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     D-x-G-x-P-x-[GA]  
REGION     116     130       GpppA-binding        
BINDING     154     154       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     C   1
BINDING     174     174       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     C   1
BINDING     185     185       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     C   1
BINDING     188     188       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     H   1

Additional information [?]

Size range 220-235 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6X7 (R1AB_SARS)
Scope
Viruses; Orthocoronavirinae
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]