General rule information
[?]
Accession |
PRU01299 |
Dates |
13-JAN-2021 (Created) 19-NOV-2022 (Last updated, Version 6) |
Predictors |
PROSITE; PS51954; COV_N7_MTASE
|
Name |
The Coronavirus (CoV) guanine-N7-methyltransferase (N7-MTase) domain |
Function |
The S-adenosyl methionine (SAM)-dependent guanine-N7- methyltransferase (N7-MTase) domain methylates the 5' guanine of the Gppp-RNA at the N7 position for mRNA capping. |
Propagated annotation
[?]
Similarity |
Belongs to the coronaviruses polyprotein 1ab family. |
GO:0032259; Biological process: methylation.
GO:0008168; Molecular function: methyltransferase activity.
case <FTGroup:1>
end case
From: PS51954 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
N7-MTase #
|
|
|
|
|
|
|
BINDING
|
|
36
|
|
42
|
|
/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
|
|
|
|
D-x-G-x-P-x-[GA]
|
|
|
REGION
|
|
116
|
|
130
|
|
GpppA-binding
|
|
|
|
|
|
|
BINDING
|
|
154
|
|
154
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1
|
|
|
|
C
|
|
1
|
BINDING
|
|
174
|
|
174
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1
|
|
|
|
C
|
|
1
|
BINDING
|
|
185
|
|
185
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1
|
|
|
|
C
|
|
1
|
BINDING
|
|
188
|
|
188
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1
|
|
|
|
H
|
|
1
|
Additional information
[?]
Size range |
220-235 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P0C6X7 (R1AB_SARS) |
Scope |
Viruses; Orthocoronavirinae |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]