ProRule PRU01299

General rule information [?]

Accession PRU01299
Dates 13-JAN-2021 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51954; COV_N7_MTASE
Name The Coronavirus (CoV) guanine-N7-methyltransferase (N7-MTase) domain
Function The S-adenosyl methionine (SAM)-dependent guanine-N7- methyltransferase (N7-MTase) domain methylates the 5' guanine of the Gppp-RNA at the N7 position for mRNA capping.
Scope(s) Viruses
Example(s) P0C6X7 (R1AB_SARS);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Keywords [?]

Gene Ontology [?]

GO:0032259; Biological process:methylation
GO:0008168; Molecular function:methyltransferase activity

Features [?]

From: PS51954
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="N7-MTase #"
BINDING 36 42 /ligand="S-adenosyl-L-methionine"
REGION 116 130 /note="GpppA-binding"
BINDING 154 154 /ligand="Zn(2+)"
C 1
BINDING 174 174 /ligand="Zn(2+)"
C 1
BINDING 185 185 /ligand="Zn(2+)"
C 1
BINDING 188 188 /ligand="Zn(2+)"
H 1

Additional information [?]

Size range 220-235 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]