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ProRule PRU01299


General rule information [?]

Accession PRU01299
Dates 13-JAN-2021 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51954; COV_N7_MTASE
Name The Coronavirus (CoV) guanine-N7-methyltransferase (N7-MTase) domain
Function The S-adenosyl methionine (SAM)-dependent guanine-N7- methyltransferase (N7-MTase) domain methylates the 5' guanine of the Gppp-RNA at the N7 position for mRNA capping.
Scope(s) Viruses
Orthocoronavirinae
Example(s) P0C6X7 (R1AB_SARS);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Keywords [?]

Methyltransferase
Transferase
case <FTGroup:1>
Metal-binding
Zinc
Zinc-finger
end case

Gene Ontology [?]

GO:0032259; Biological process:methylation
GO:0008168; Molecular function:methyltransferase activity

Features [?]

From: PS51954
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="N7-MTase #"
BINDING 36 42 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 D-x-G-x-P-x-[GA]
REGION 116 130 /note="GpppA-binding"
BINDING 154 154 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 174 174 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 185 185 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 188 188 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 H 1

Additional information [?]

Size range 220-235 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]