We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01299
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01299
General rule information
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| Accession | PRU01299 |
| Dates | 13-JAN-2021 (Created)
19-NOV-2022 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51954; COV_N7_MTASE |
Name | The Coronavirus (CoV) guanine-N7-methyltransferase (N7-MTase) domain |
| Function | The S-adenosyl methionine (SAM)-dependent guanine-N7- methyltransferase (N7-MTase) domain methylates the 5' guanine of the Gppp-RNA at the N7 position for mRNA capping. |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P0C6X7; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Keywords
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| Methyltransferase | |
| Transferase | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| Zinc-finger | |
| end case | |
Gene Ontology
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| GO:0032259; Biological process:methylation |
| GO:0008168; Molecular function:methyltransferase activity |
Features
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| From: PS51954 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="N7-MTase #" | |||||||||
| BINDING | 36 | 42 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D-x-G-x-P-x-[GA] | ||||||||
| REGION | 116 | 130 | /note="GpppA-binding" | |||||||||
| BINDING | 154 | 154 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
C | 1 | |||||||
| BINDING | 174 | 174 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
C | 1 | |||||||
| BINDING | 185 | 185 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
C | 1 | |||||||
| BINDING | 188 | 188 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
H | 1 | |||||||
Additional information
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| Size range | 220-235 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [30] All [ 30 ]
- Retrieve set of proteins with 3D structure for this domain