ProRule PRU01300
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01300 |
| Accession | PRU01300 |
| Dates | 20-JAN-2021 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51955; NIV_2_O_MTASE |
Name | Nidovirus 2'-O-methyltransferase (2'-O-MTase) domain |
| Function | The 3'-terminal domain of the most conserved ORF1b in three of the four families of the order Nidovirales (except for the family Arteriviridae) encodes a 2'-O-methyltransferase (2'-O-MTase), known as non structural protein (Nsp) 16 in the family Coronaviridae and implicated in methylation of the 5' cap structure of nidoviral mRNAs. |
| Scope(s) |
Viruses Nidovirales |
| Example(s) | P18457 (R1AB_CVPFS); |
Propagated annotation
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Keywords
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| Transferase | |
| Methyltransferase | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0032259; Biological process:methylation | |
| GO:0008168; Molecular function:methyltransferase activity | |
Features
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| From: PS51955 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Nidovirus-type SAM-dependent 2'-O-MTase #" | |||||||||
| ACT_SITE | 45 | 45 | K | 1 | ||||||||
| ACT_SITE | 125 | 125 | D | 1 | ||||||||
| ACT_SITE | 155 | 155 | K | 1 | ||||||||
| ACT_SITE | 188 | 188 | E | 1 | ||||||||
Additional information
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| Size range | 255-305 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [38] All [ 38 ]
- Retrieve set of proteins with 3D structure for this domain