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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01300


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01300
General rule information [?]

Accession PRU01300
Dates 20-JAN-2021 (Created)
20-JAN-2021 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51955; NIV_2_O_MTASE
Name Nidovirus 2'-O-methyltransferase (2'-O-MTase) domain
Function The 3'-terminal domain of the most conserved ORF1b in three of the four families of the order Nidovirales (except for the family Arteriviridae) encodes a 2'-O-methyltransferase (2'-O-MTase), known as non structural protein (Nsp) 16 in the family Coronaviridae and implicated in methylation of the 5' cap structure of nidoviral mRNAs.
Scope(s) Viruses
Nidovirales
Example(s) P18457;

Propagated annotation [?]

Keywords [?]

Transferase
Methyltransferase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0032259; Biological process:methylation
GO:0008168; Molecular function:methyltransferase activity

Features [?]

From: PS51955
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Nidovirus-type SAM-dependent 2'-O-MTase #"
ACT_SITE 45 45 K 1
ACT_SITE 125 125 D 1
ACT_SITE 155 155 K 1
ACT_SITE 188 188 E 1

Additional information [?]

Size range 255-305 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]