ProRule PRU01300

General rule information [?]

Accession PRU01300
Dates 20-JAN-2021 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS51955; NIV_2_O_MTASE
Name Nidovirus 2'-O-methyltransferase (2'-O-MTase) domain
Function The 3'-terminal domain of the most conserved ORF1b in three of the four families of the order Nidovirales (except for the family Arteriviridae) encodes a 2'-O-methyltransferase (2'-O-MTase), known as non structural protein (Nsp) 16 in the family Coronaviridae and implicated in methylation of the 5' cap structure of nidoviral mRNAs.
Scope(s) Viruses
Example(s) P18457 (R1AB_CVPFS);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0032259; Biological process:methylation
GO:0008168; Molecular function:methyltransferase activity

Features [?]

From: PS51955
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Nidovirus-type SAM-dependent 2'-O-MTase #"
ACT_SITE 45 45 K 1
ACT_SITE 125 125 D 1
ACT_SITE 155 155 K 1
ACT_SITE 188 188 E 1

Additional information [?]

Size range 255-305 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]