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annotation rule: PRU01300

General rule information [?]

Accession PRU01300
Dates 20-JAN-2021 (Created)
20-JAN-2021 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51955; NIV_2_O_MTASE
Name Nidovirus 2'-O-methyltransferase (2'-O-MTase) domain
Function The 3'-terminal domain of the most conserved ORF1b in three of the four families of the order Nidovirales (except for the family Arteriviridae) encodes a 2'-O-methyltransferase (2'-O-MTase), known as non structural protein (Nsp) 16 in the family Coronaviridae and implicated in methylation of the 5' cap structure of nidoviral mRNAs.

Propagated annotation [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0032259; Biological process: methylation.
GO:0008168; Molecular function: methyltransferase activity.

Keywords [?]

end case

Features [?]

From: PS51955
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Nidovirus-type SAM-dependent 2'-O-MTase #        
ACT_SITE     45     45             K   1
ACT_SITE     125     125             D   1
ACT_SITE     155     155             K   1
ACT_SITE     188     188             E   1

Additional information [?]

Size range 255-305 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P18457 (R1AB_CVPFS)
Viruses; Nidovirales
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]