General rule information
[?]
Accession |
PRU01300 |
Dates |
20-JAN-2021 (Created) 20-JAN-2021 (Last updated, Version 1) |
Predictors |
PROSITE; PS51955; NIV_2_O_MTASE
|
Name |
Nidovirus 2'-O-methyltransferase (2'-O-MTase) domain |
Function |
The 3'-terminal domain of the most conserved ORF1b in three of the four families of the order Nidovirales (except for the family Arteriviridae) encodes a 2'-O-methyltransferase (2'-O-MTase), known as non structural protein (Nsp) 16 in the family Coronaviridae and implicated in methylation of the 5' cap structure of nidoviral mRNAs. |
Propagated annotation
[?]
case <FTGroup:1>
GO:0032259; Biological process: methylation.
GO:0008168; Molecular function: methyltransferase activity.
end case
From: PS51955 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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DOMAIN
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from
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to
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Nidovirus-type SAM-dependent 2'-O-MTase #
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ACT_SITE
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45
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45
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|
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K
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1
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ACT_SITE
|
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125
|
|
125
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|
|
|
|
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D
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1
|
ACT_SITE
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|
155
|
|
155
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|
|
|
|
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K
|
|
1
|
ACT_SITE
|
|
188
|
|
188
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|
|
|
|
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E
|
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1
|
Additional information
[?]
Size range |
255-305 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P18457 (R1AB_CVPFS) |
Scope |
Viruses; Nidovirales |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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