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| annotation rule: PRU01300 |
General rule information
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| Accession | PRU01300 |
| Dates | 20-JAN-2021 (Created) 20-JAN-2021 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS51955; NIV_2_O_MTASE |
| Name | Nidovirus 2'-O-methyltransferase (2'-O-MTase) domain |
| Function | The 3'-terminal domain of the most conserved ORF1b in three of the four families of the order Nidovirales (except for the family Arteriviridae) encodes a 2'-O-methyltransferase (2'-O-MTase), known as non structural protein (Nsp) 16 in the family Coronaviridae and implicated in methylation of the 5' cap structure of nidoviral mRNAs. |
Propagated annotation
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Gene Ontology
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case <FTGroup:1>
GO:0032259; Biological process: methylation.
GO:0008168; Molecular function: methyltransferase activity.
GO:0008168; Molecular function: methyltransferase activity.
Keywords
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end case
Features
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| From: PS51955 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Nidovirus-type SAM-dependent 2'-O-MTase # | |||||||||
| ACT_SITE | 45 | 45 | K | 1 | ||||||||
| ACT_SITE | 125 | 125 | D | 1 | ||||||||
| ACT_SITE | 155 | 155 | K | 1 | ||||||||
| ACT_SITE | 188 | 188 | E | 1 | ||||||||
Additional information
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| Size range | 255-305 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P18457 (R1AB_CVPFS) |
| Scope | Viruses; Nidovirales |
| Comments | None |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Viruses [37]
- Retrieve set of proteins with 3D structure for this domain