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annotation rule: PRU01305 |
Accession | PRU01305 |
Dates | 1-FEB-2021 (Created) 1-FEB-2021 (Last updated, Version 1) |
Data class | Domain |
Predictors | PROSITE; PS51960; COV_NSP15_NTD |
Name | Coronavirus (CoV) Nsp15 N-terminal oligomerization domain |
Function | Nsp15 is a nidoviral uridylate-specific endoribonuclease (NendoU) that consists of three distinct domains, a small N-terminal, an intermediate- sized middle, and a large C-terminal NendoU domain. CoV Nsp15 forms double- ring hexamers made of dimers of trimers. The hexameric form is thought to be the fully active form of CoV Nsp15 and the hexamer is stabilized by interactions of the N-terminal oligomerization domain. |
Similarity | Belongs to the coronaviruses polyprotein 1ab family. |
From: PS51960 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Nsp15 N-terminal oligomerization # |
Size range | 55-65 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P0C6W9 (R1AB_CVBM) |
Scope | Viruses; Orthocoronavirinae |
Comments | None |
Viruses | [30] |