ProRule PRU01305
General rule information
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| Accession | PRU01305 |
| Dates | 1-FEB-2021 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51960; COV_NSP15_NTD |
Name | Coronavirus (CoV) Nsp15 N-terminal oligomerization domain |
| Function | Nsp15 is a nidoviral uridylate-specific endoribonuclease (NendoU) that consists of three distinct domains, a small N-terminal, an intermediate- sized middle, and a large C-terminal NendoU domain. CoV Nsp15 forms double- ring hexamers made of dimers of trimers. The hexameric form is thought to be the fully active form of CoV Nsp15 and the hexamer is stabilized by interactions of the N-terminal oligomerization domain. |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P0C6W9 (R1AB_CVBM); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Features
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| From: PS51960 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Nsp15 N-terminal oligomerization #" | |||||||||
Additional information
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| Size range | 55-65 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [30] All [ 30 ]
- Retrieve set of proteins with 3D structure for this domain