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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01305


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01305
General rule information [?]

Accession PRU01305
Dates 01-FEB-2021 (Created)
01-FEB-2021 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51960; COV_NSP15_NTD
Name Coronavirus (CoV) Nsp15 N-terminal oligomerization domain
Function Nsp15 is a nidoviral uridylate-specific endoribonuclease (NendoU) that consists of three distinct domains, a small N-terminal, an intermediate- sized middle, and a large C-terminal NendoU domain. CoV Nsp15 forms double- ring hexamers made of dimers of trimers. The hexameric form is thought to be the fully active form of CoV Nsp15 and the hexamer is stabilized by interactions of the N-terminal oligomerization domain.
Scope(s) Viruses
Orthocoronavirinae
Example(s) P0C6W9;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Features [?]

From: PS51960
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Nsp15 N-terminal oligomerization #"

Additional information [?]

Size range 55-65 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]