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| annotation rule: PRU01305 |
General rule information
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| Accession | PRU01305 |
| Dates | 1-FEB-2021 (Created) 1-FEB-2021 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS51960; COV_NSP15_NTD |
| Name | Coronavirus (CoV) Nsp15 N-terminal oligomerization domain |
| Function | Nsp15 is a nidoviral uridylate-specific endoribonuclease (NendoU) that consists of three distinct domains, a small N-terminal, an intermediate- sized middle, and a large C-terminal NendoU domain. CoV Nsp15 forms double- ring hexamers made of dimers of trimers. The hexameric form is thought to be the fully active form of CoV Nsp15 and the hexamer is stabilized by interactions of the N-terminal oligomerization domain. |
Propagated annotation
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Comments
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| Similarity | Belongs to the coronaviruses polyprotein 1ab family. |
Features
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| From: PS51960 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Nsp15 N-terminal oligomerization # | |||||||||
Additional information
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| Size range | 55-65 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P0C6W9 (R1AB_CVBM) |
| Scope | Viruses; Orthocoronavirinae |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Viruses [30]
- Retrieve set of proteins with 3D structure for this domain