Home  |  Contact
annotation rule: PRU01305

General rule information [?]

Accession PRU01305
Dates 1-FEB-2021 (Created)
1-FEB-2021 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51960; COV_NSP15_NTD
Name Coronavirus (CoV) Nsp15 N-terminal oligomerization domain
Function Nsp15 is a nidoviral uridylate-specific endoribonuclease (NendoU) that consists of three distinct domains, a small N-terminal, an intermediate- sized middle, and a large C-terminal NendoU domain. CoV Nsp15 forms double- ring hexamers made of dimers of trimers. The hexameric form is thought to be the fully active form of CoV Nsp15 and the hexamer is stabilized by interactions of the N-terminal oligomerization domain.

Propagated annotation [?]

Comments [?]

Similarity Belongs to the coronaviruses polyprotein 1ab family.

Features [?]

From: PS51960
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Nsp15 N-terminal oligomerization #        

Additional information [?]

Size range 55-65 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6W9 (R1AB_CVBM)
Viruses; Orthocoronavirinae
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]