ProRule PRU01305

General rule information [?]

Accession PRU01305
Dates 1-FEB-2021 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS51960; COV_NSP15_NTD
Name Coronavirus (CoV) Nsp15 N-terminal oligomerization domain
Function Nsp15 is a nidoviral uridylate-specific endoribonuclease (NendoU) that consists of three distinct domains, a small N-terminal, an intermediate- sized middle, and a large C-terminal NendoU domain. CoV Nsp15 forms double- ring hexamers made of dimers of trimers. The hexameric form is thought to be the fully active form of CoV Nsp15 and the hexamer is stabilized by interactions of the N-terminal oligomerization domain.
Scope(s) Viruses
Example(s) P0C6W9 (R1AB_CVBM);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Features [?]

From: PS51960
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Nsp15 N-terminal oligomerization #"

Additional information [?]

Size range 55-65 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]